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RACK1 is involved in β-amyloid impairment of muscarinic regulation of GABAergic transmission.

Abstract：

:RACK1 (receptor for activated C-kinase 1), an anchoring protein that shuttles activated PKC to cellular membranes, plays an important role in PKC-mediated signal transduction pathways. A significant loss of RACK1 has been found in the brain of aging animals and Alzheimer's disease (AD) patients, which implicates the potential involvement of RACK1 in altered PKC activation associated with dementia. Our previous studies have demonstrated that GABAergic inhibition in prefrontal cortex, which is important for cognitive processes like "working memory", is regulated by muscarinic receptors via a PKC-dependent mechanism, and this effect is impaired by β-amyloid peptide (Aβ). In this study, we found that Aβ oligomers decreased RACK1 distribution in the membrane fraction of cortical neurons. Moreover, overexpression of RACK1 rescued the effect of muscarinic receptors on GABAergic transmission in Aβ-treated cortical cultures in vitro and Aβ-injected cortical neurons in vivo. These results suggest that the Aβ-induced loss of RACK1 distribution in the cell membrane may underlie the Aβ impairment of muscarinic regulation of PKC and GABAergic transmission. Thus, RACK1 provides a potential therapeutic target that can restore some of the impaired cellular processes by Aβ.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

Liu W,Dou F,Feng J,Yan Z

doi

10.1016/j.neurobiolaging.2009.10.017

subject

Has Abstract

pub_date

2011-10-01 00:00:00

pages

1818-26

issue

10

eissn

0197-4580

issn

1558-1497

pii

S0197-4580(09)00358-3

journal_volume

32

pub_type

杂志文章

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