Abstract：
:Changes of performance monitoring during and after learning of stimulus-response (S-R) associations were examined in younger and older adults using event-related brain potentials (ERPs). To determine whether age-related differences in performance monitoring are attenuated when learning performance is equalized between age groups, participants learned S-R associations until they reached a learning criterion. After completed learning, time pressure was introduced to assess whether time pressure pronounces age-related differences in performance monitoring. In the initial learning phase, performance monitoring was unspecific, indicated by similar-sized ERN/Ne (error-related/error negativity) and CRN (correct response-related negativity) amplitudes. With advanced learning, ERN/Ne and CRN amplitudes dissociated in younger participants, suggesting error-specific performance monitoring, whereas in older participants, performance monitoring remained unspecific. However, after completed learning and under time pressure, larger ERN/Ne than CRN amplitudes were observed in older participants, too. This finding suggests that error-specific performance monitoring develops with learning in younger, but not necessarily in older adults. The administration of time pressure seemed to force older adults to monitor error responses more specifically.
journal_name
Neurobiol Agingjournal_title
Neurobiology of agingauthors
Pietschmann M,Endrass T,Kathmann Ndoi
10.1016/j.neurobiolaging.2009.07.016subject
Has Abstractpub_date
2011-07-01 00:00:00pages
1320-30issue
7eissn
0197-4580issn
1558-1497pii
S0197-4580(09)00247-4journal_volume
32pub_type
杂志文章abstract：:Age-related synaptic change is associated with the functional decline of the nervous system. It is unknown whether this synaptic change is the cause or the consequence of neuronal cell loss. We have addressed this question by examining mice genetically engineered to over- or underexpress neuregulin-1 (NRG1), a direct ...
journal_title：Neurobiology of aging
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journal_title：Neurobiology of aging
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journal_title：Neurobiology of aging
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journal_title：Neurobiology of aging
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journal_title：Neurobiology of aging
pub_type： 杂志文章,评审
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journal_title：Neurobiology of aging
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journal_title：Neurobiology of aging
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journal_title：Neurobiology of aging
pub_type： 杂志文章
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journal_title：Neurobiology of aging
pub_type： 杂志文章
doi：10.1016/j.neurobiolaging.2015.10.014
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journal_title：Neurobiology of aging
pub_type： 杂志文章
doi：10.1016/j.neurobiolaging.2006.11.011
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journal_title：Neurobiology of aging
pub_type： 杂志文章
doi：10.1016/j.neurobiolaging.2010.07.016
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journal_title：Neurobiology of aging
pub_type： 杂志文章
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journal_title：Neurobiology of aging
pub_type： 杂志文章
doi：10.1016/j.neurobiolaging.2005.03.010
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journal_title：Neurobiology of aging
pub_type： 杂志文章
doi：10.1016/j.neurobiolaging.2015.02.006
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journal_title：Neurobiology of aging
pub_type： 杂志文章,评审
doi：10.1016/j.neurobiolaging.2011.09.006
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journal_title：Neurobiology of aging
pub_type： 杂志文章,meta分析,评审
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journal_title：Neurobiology of aging
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journal_title：Neurobiology of aging
pub_type： 杂志文章
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journal_title：Neurobiology of aging
pub_type： 杂志文章
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journal_title：Neurobiology of aging
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journal_title：Neurobiology of aging
pub_type： 杂志文章
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journal_title：Neurobiology of aging
pub_type： 杂志文章
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journal_title：Neurobiology of aging
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Neurobiology of aging
pub_type： 杂志文章
doi：10.1016/j.neurobiolaging.2017.12.008
更新日期：2018-04-01 00:00:00
abstract：:An individual's genetic makeup plays an important role in determining susceptibility to cognitive aging. Identifying the specific genes that contribute to cognitive aging may aid in early diagnosis of at-risk patients, as well as identify novel therapeutics targets to treat or prevent development of symptoms. Challeng...
journal_title：Neurobiology of aging
pub_type： 杂志文章
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