Abstract:
:We sought to examine the relations between age, gender and brain volumes in an elderly population; we also sought to examine ways of measuring these relations. Three sets of analyses were used: correlational analyses, in which correlations between independent variables and brain volumes were calculated without correction for intracranial volume (ICV); covariational analyses, in which ICV was used as a covariate in regression equations; and ratio analyses, in which the dependent variable was the ratio of brain volume to ICV. These analyses yielded similar results, except that (as expected) adjusting for ICV altered estimates of gender differences. Analyses of age showed decreases in left caudate, putamen, and right hippocampus and an increase in CSF, a result generally in accord with previous findings. However, we also found a significant decrease of white-matter volumes and no significant decrease in total gray-matter volumes. Correlational analyses showed that men did not always have larger volumes despite their larger head size; women generally had larger volumes after adjusting for ICV. We found no age-gender interactions.
journal_name
Neurobiol Agingjournal_title
Neurobiology of agingauthors
Greenberg DL,Messer DF,Payne ME,Macfall JR,Provenzale JM,Steffens DC,Krishnan RRdoi
10.1016/j.neurobiolaging.2006.09.016subject
Has Abstractpub_date
2008-02-01 00:00:00pages
290-302issue
2eissn
0197-4580issn
1558-1497pii
S0197-4580(06)00350-2journal_volume
29pub_type
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