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Four-hydroxynonenal, a product of lipid peroxidation, is increased in the brain in Alzheimer's disease.

Abstract：

:Recent studies have implicated increased oxidative stress in the pathogenesis of Alzheimer's disease (AD). Increased lipid peroxidation and decreased polyunsaturated fatty acid levels have been described in the brain in AD. Four-hydroxynonenal (HNE), an aldehyde product of lipid peroxidation, has been demonstrated to be a neurotoxin in tissue culture and in vivo studies and is elevated in ventricular fluid in AD. We report here an increase in mean free HNE in multiple brain regions in AD compared with age-matched control subjects. These increases reached statistical significance in the amygdala and hippocampus and parahippocampal gyrus, regions showing the most pronounced histopathological alterations in AD. This study, in conjunction with cell culture studies, suggests that HNE may be an important substance in the pathogenesis of neuron degeneration in AD.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

Markesbery WR,Lovell MA

doi

10.1016/s0197-4580(98)00009-8

subject

Has Abstract

pub_date

1998-01-01 00:00:00

pages

33-6

issue

1

eissn

0197-4580

issn

1558-1497

pii

S0197-4580(98)00009-8

journal_volume

19

pub_type

杂志文章

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