Case control analysis of LRRK2 Gly2385Arg in Alzheimer's disease.

abstract：:We examined patterns of cortical thickness loss and cognitive decline over time in 19 patients with Alzheimer's disease (AD), 10 with behavioral variant frontotemporal dementia (bvFTD), and 34 controls with a mean interval of 2.1 ± 0.4 years. We measured vertexwise and regional cortical thickness changes of 6 lobar re...

journal_title：Neurobiology of aging

authors： Möller C,Hafkemeijer A,Pijnenburg YAL,Rombouts SARB,van der Grond J,Dopper E,van Swieten J,Versteeg A,Steenwijk MD,Barkhof F,Scheltens P,Vrenken H,van der Flier WM

更新日期：2016-02-01 00:00:00

abstract：:Parkinson's disease (PD) is a progressive neurodegenerative disease with typical motor symptoms due to the preferential loss of midbrain dopaminergic (mDA) neurons in the Substantia nigra pars compacta. Several proteins of the homeodomain family are crucial for the development of mDA neurons. These proteins remain exp...

journal_title：Neurobiology of aging

authors： Fuchs J,Mueller JC,Lichtner P,Schulte C,Munz M,Berg D,Wüllner U,Illig T,Sharma M,Gasser T

更新日期：2009-05-01 00:00:00

abstract：:Aging is accompanied by increased neuroinflammation, synaptic dysfunction, and cognitive deficits both in rodents and humans, yet the onset and progression of these deficits throughout the life span remain unknown. These aging-related deficits affect the quality of life and present challenges to our aging society. Her...

journal_title：Neurobiology of aging

authors： Rogers JT,Liu CC,Zhao N,Wang J,Putzke T,Yang L,Shinohara M,Fryer JD,Kanekiyo T,Bu G

更新日期：2017-05-01 00:00:00

abstract：:Neuroimage measures from magnetic resonance (MR) imaging, such as cortical thickness, have been playing an increasingly important role in searching for biomarkers of Alzheimer's disease (AD). Recent studies show that, AD, mild cognitive impairment (MCI) and normal control (NC) can be distinguished with relatively high...

journal_title：Neurobiology of aging

authors： Li Y,Wang Y,Wu G,Shi F,Zhou L,Lin W,Shen D,Alzheimer's Disease Neuroimaging Initiative.

更新日期：2012-02-01 00:00:00

abstract：:Recently, two large, and independent genome wide association studies of late-onset Alzheimer's disease (AD) established association with the same rs11136000 variation in the clusterin (CLU) gene. In addition, one variation, rs3851179, in the phosphatidylinositol binding clathrin assembly protein (PICALM) gene and one ...

journal_title：Neurobiology of aging

authors： Mengel-From J,Christensen K,McGue M,Christiansen L

更新日期：2011-03-01 00:00:00

abstract：:The supraoptic nucleus of the F344 rat shows an age-related dendritic regression. In order to determine whether this previously observed dendritic regression may have been related to extrinsic (to the cell) hormonal, neurotoxic, or other circulating factors unique to the hypothalamus of older brains, we conducted a qu...

journal_title：Neurobiology of aging

authors： Kaplan AS,Gash DM,Flood DG,Coleman PD

更新日期：1985-10-01 00:00:00

abstract：:Decreased levels of cerebrospinal fluid (CSF) Abeta42 is a diagnostic marker of Alzheimer's disease. To clarify the biological basis of this marker, the physiological alterations of CSF Abeta40 and Abeta42 by aging were studied. CSF samples from 92 normal subjects between 8 and 89 years old were measured using a speci...

journal_title：Neurobiology of aging

authors： Shoji M,Kanai M,Matsubara E,Tomidokoro Y,Shizuka M,Ikeda Y,Ikeda M,Harigaya Y,Okamoto K,Hirai S

更新日期：2001-03-01 00:00:00

abstract：:Age-related changes in resting levels of the free intracellular calcium concentration ([Ca2+]i) as well as alterations of the rise in [Ca2+]i following depolarization have been investigated in acutely isolated brain cells of various regions of the rat brain. Characterization of the Ca2+ responses following KCl depolar...

journal_title：Neurobiology of aging

authors： Hartmann H,Velbinger K,Eckert A,Müller WE

更新日期：1996-07-01 00:00:00

abstract：:New highly-accurate stereological methods for estimating the total numbers of neurons in brain structures have been used to test for age-related neuron loss in the human hippocampal formation. Across the age range of 13 to 85 years, there was a substantial loss of neurons in the subiculum (52%) and in the hilus of the...

journal_title：Neurobiology of aging

authors： West MJ

更新日期：1993-07-01 00:00:00

abstract：:Abnormal elevations in ammonia have been implicated in the pathogenesis of Alzheimer's disease. However, the biochemical mechanism(s) leading to increased ammonia in Alzheimer's disease have not yet been identified. A potential source of increased ammonia production is adenosine monophosphate (AMP) deaminase, an impor...

journal_title：Neurobiology of aging

authors： Sims B,Powers RE,Sabina RL,Theibert AB

更新日期：1998-09-01 00:00:00

abstract：:The classic hallmarks of Alzheimer's disease are the deposition of amyloid in plaques and in the cerebrovasculature, and the emergence of neurofibrillary tangles in neurons. The interplay between these two pathologic processes, on the one hand, and the degeneration of neurons and loss of cognitive functions on the oth...

journal_title：Neurobiology of aging

authors： Neve RL,Boyce FM,McPhie DL,Greenan J,Oster-Granite ML

更新日期：1996-03-01 00:00:00

abstract：:Recent studies have implicated increased oxidative stress in the pathogenesis of Alzheimer's disease (AD). Increased lipid peroxidation and decreased polyunsaturated fatty acid levels have been described in the brain in AD. Four-hydroxynonenal (HNE), an aldehyde product of lipid peroxidation, has been demonstrated to ...

journal_title：Neurobiology of aging

authors： Markesbery WR,Lovell MA

更新日期：1998-01-01 00:00:00

abstract：:Aged rats perform poorly on spatial learning tasks, a cognitive impairment which has been linked to the failure of hippocampal networks to fully encode changes in the external environment [Barnes CA, Suster MS, Shen J, McNaughton BL. Multistability of cognitive maps in the hippocampus of old rats. Nature 1997;388(6639...

journal_title：Neurobiology of aging

authors： Wilson IA,Ikonen S,Gurevicius K,McMahan RW,Gallagher M,Eichenbaum H,Tanila H

更新日期：2005-07-01 00:00:00

abstract：:We have developed a cell-based phenotypic automated high-content screening approach for N2a cells expressing the pro-aggregant repeat domain of tau protein (tauRDΔK), which allows analysis of a chemogenomic library of 1649 compounds for their effect on the inhibition or stimulation of intracellular tau aggregation. We...

journal_title：Neurobiology of aging

authors： Pickhardt M,Tassoni M,Denner P,Kurkowsky B,Kitanovic A,Möhl C,Fava E,Mandelkow E

更新日期：2019-04-01 00:00:00

abstract：:We hypothesized that dopamine neuromodulation might affect cortical excitability in Parkinson's disease (PD) patients set in quiet wakefulness, as revealed by resting state eyes-closed electroencephalographic (rsEEG) rhythms at alpha frequencies (8-12 Hz). Clinical and rsEEG rhythms in PD with dementia (N = 35), PD wi...

journal_title：Neurobiology of aging

authors： Babiloni C,Del Percio C,Lizio R,Noce G,Lopez S,Soricelli A,Ferri R,Pascarelli MT,Catania V,Nobili F,Arnaldi D,Famà F,Orzi F,Buttinelli C,Giubilei F,Bonanni L,Franciotti R,Onofrj M,Stirpe P,Fuhr P,Gschwandtner U,

更新日期：2019-01-01 00:00:00

abstract：:The methionine/valine (M/V) polymorphism at codon 129 within the prion protein gene (PRNP) represents a known risk factor for Creutzfeldt-Jakob disease (CJD). Few authors reported also the effects of this polymorphism on the risk of Alzheimer's disease (AD), although with controversial results. To better clarify this ...

journal_title：Neurobiology of aging

authors： Del Bo R,Scarlato M,Ghezzi S,Martinelli-Boneschi F,Fenoglio C,Galimberti G,Galbiati S,Virgilio R,Galimberti D,Ferrarese C,Scarpini E,Bresolin N,Comi GP

更新日期：2006-05-01 00:00:00

abstract：:Glial cell line-derived neurotrophic factor (GDNF) supports the viability of midbrain dopamine (DA) neurons that degenerate in Parkinson's disease. Middle-aged, 12 month old, Gdnf heterozygous (Gdnf(+/-)) mice have diminished spontaneous locomotor activity and enhanced synaptosomal DA uptake compared with wild type mi...

journal_title：Neurobiology of aging

authors： Littrell OM,Pomerleau F,Huettl P,Surgener S,McGinty JF,Middaugh LD,Granholm AC,Gerhardt GA,Boger HA

更新日期：2012-02-01 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF) has emerged as a major regulator of synaptic plasticity in the adult brain and acute BDNF infusion has been shown to trigger long-term potentiation (BDNF-LTP) in adult rats. Here we compared the effects of acute BDNF infusion in young adult and aged anesthetized rats. In young ...

journal_title：Neurobiology of aging

authors： Gooney M,Messaoudi E,Maher FO,Bramham CR,Lynch MA

更新日期：2004-11-01 00:00:00

abstract：:Mutations in the profilin 1 (PFN1) gene, encoding a member of the profilin family of small actin-binding proteins, have been recently reported in patients with familial amyotrophic lateral sclerosis (ALS). In this study we aimed to determine the prevalence of PFN1 mutations by sequencing the coding region of this gene...

journal_title：Neurobiology of aging

authors： Daoud H,Dobrzeniecka S,Camu W,Meininger V,Dupré N,Dion PA,Rouleau GA

更新日期：2013-04-01 00:00:00

abstract：:Iron overload may contribute to the risk of Alzheimer's disease (AD). In the Epistasis Project, with 1757 cases of AD and 6295 controls, we studied 4 variants in 2 genes of iron metabolism: hemochromatosis (HFE) C282Y and H63D, and transferrin (TF) C2 and -2G/A. We replicated the reported interaction between HFE 282Y ...

journal_title：Neurobiology of aging

authors： Lehmann DJ,Schuur M,Warden DR,Hammond N,Belbin O,Kölsch H,Lehmann MG,Wilcock GK,Brown K,Kehoe PG,Morris CM,Barker R,Coto E,Alvarez V,Deloukas P,Mateo I,Gwilliam R,Combarros O,Arias-Vásquez A,Aulchenko YS,Ikram MA

更新日期：2012-01-01 00:00:00

abstract：:Brain deposits of amyloid beta peptide (Abeta) have been a diagnostic hallmark of Alzheimer's disease (AD) for nearly a century. Recent studies have demonstrated that Abeta is also present in peripheral blood. Here, we present evidence that circulating Abeta42 is subject to complement C3b-dependent adherence to comple...

journal_title：Neurobiology of aging

authors： Rogers J,Li R,Mastroeni D,Grover A,Leonard B,Ahern G,Cao P,Kolody H,Vedders L,Kolb WP,Sabbagh M

更新日期：2006-12-01 00:00:00

abstract：:A large number of gene products that are enriched in the striatum have ill-defined functions, although they may have key roles in age-dependent neurodegenerative diseases affecting the striatum, especially Huntington disease (HD). In the present study, we focused on Abhd11os, (called ABHD11-AS1 in human) which is a pu...

journal_title：Neurobiology of aging

authors： Francelle L,Galvan L,Gaillard MC,Petit F,Bernay B,Guillermier M,Bonvento G,Dufour N,Elalouf JM,Hantraye P,Déglon N,de Chaldée M,Brouillet E

更新日期：2015-03-01 00:00:00

abstract：:This study modeled predementia Alzheimer's disease clinical trials. Longitudinal data from cognitively normal (CN) and mild cognitive impairment (MCI) participants in the Alzheimer's Disease Neuroimaging Initiative were used to calculate sample size requirements for trials using outcome measures, including the Clinica...

journal_title：Neurobiology of aging

authors： Grill JD,Di L,Lu PH,Lee C,Ringman J,Apostolova LG,Chow N,Kohannim O,Cummings JL,Thompson PM,Elashoff D,Alzheimer's Disease Neuroimaging Initiative.

更新日期：2013-01-01 00:00:00

abstract：:Four biopsies of the brain cortex of patients with Alzheimer's disease were used for ultrastructural studies. Three-dimensional reconstruction and morphometric studies of three classical plaques were carried out to determine the distribution of the astrocytes and their processes, and spatial relationships between astr...

journal_title：Neurobiology of aging

authors： Wisniewski HM,Wegiel J

更新日期：1991-09-01 00:00:00

abstract：:Individuals with Down syndrome (DS), caused by trisomy of chromosome 21, inevitably develop characteristic Alzheimer's disease (AD) neuropathology, including neuritic plaques, neurofibrillary tangles, and neuronal loss. Amyloid-β protein, the major component of neuritic plaques, is the proteolytic product of amyloid-β...

journal_title：Neurobiology of aging

authors： Wu Y,Deng Y,Zhang S,Luo Y,Cai F,Zhang Z,Zhou W,Li T,Song W

更新日期：2015-01-01 00:00:00

abstract：:The knowledge base of nutrition and the brain is steadily expanding. Much of the research is aimed at ways to protect the brain from damage. In adults, the major causes of brain damage are aging and dementia. The most prominent dementia, and the condition that grabs the most public attention, is Alzheimer's disease. T...

journal_title：Neurobiology of aging

authors： Cooper JK

更新日期：2014-09-01 00:00:00

abstract：:Accumulation of disease-related proteins is a characteristic event observed in the pathogenesis of neurodegenerative diseases. β-secretase (BACE)-1, which initiates generation of β-amyloid (Aβ), is increased in the Alzheimer's diseased brain. However, the mechanisms of BACE1 accumulation in Alzheimer's disease are lar...

journal_title：Neurobiology of aging

authors： Yun SM,Cho SJ,Song JC,Song SY,Jo SA,Jo C,Yoon K,Tanzi RE,Choi EJ,Koh YH

更新日期：2013-03-01 00:00:00

abstract：:Genetic variants are implicated in the development of amyotrophic lateral sclerosis (ALS), but it is unclear whether the burden of rare variants in ALS genes has an effect on survival. We performed whole genome sequencing on 8 familial ALS (FALS) patients with superoxide dismutase 1 (SOD1) mutation and whole exome seq...

journal_title：Neurobiology of aging

authors： Pang SY,Hsu JS,Teo KC,Li Y,Kung MHW,Cheah KSE,Chan D,Cheung KMC,Li M,Sham PC,Ho SL

更新日期：2017-10-01 00:00:00

abstract：:Despite cognitive and physical declines, it has been suggested that older adults remain able to regulate their emotions effectively. However, whether this is true for all emotion regulation processes has not been established. We hypothesized that cognitive reappraisal, a form of emotion regulation requiring intact cog...

journal_title：Neurobiology of aging

authors： Opitz PC,Rauch LC,Terry DP,Urry HL

更新日期：2012-04-01 00:00:00

abstract：:Age related alterations in mnemonic ability and in the functional status of muscarinic receptors were evaluated and compared to biochemical measures of pre and post-synaptic cholinergic functioning. Retention of a single trial passive avoidance task was considerably disturbed as a function of aging. The functional sta...

journal_title：Neurobiology of aging

authors： Lippa AS,Pelham RW,Beer B,Critchett DJ,Dean RL,Bartus RT

更新日期：1980-07-01 00:00:00