Abstract:
:A large number of gene products that are enriched in the striatum have ill-defined functions, although they may have key roles in age-dependent neurodegenerative diseases affecting the striatum, especially Huntington disease (HD). In the present study, we focused on Abhd11os, (called ABHD11-AS1 in human) which is a putative long noncoding RNA (lncRNA) whose expression is enriched in the mouse striatum. We confirm that despite the presence of 2 small open reading frames (ORFs) in its sequence, Abhd11os is not translated into a detectable peptide in living cells. We demonstrate that Abhd11os levels are markedly reduced in different mouse models of HD. We performed in vivo experiments in mice using lentiviral vectors encoding either Abhd11os or a small hairpin RNA targeting Abhd11os. Results show that Abhd11os overexpression produces neuroprotection against an N-terminal fragment of mutant huntingtin, whereas Abhd11os knockdown is protoxic. These novel results indicate that the loss lncRNA Abhd11os likely contribute to striatal vulnerability in HD. Our study emphasizes that lncRNA may play crucial roles in neurodegenerative diseases.
journal_name
Neurobiol Agingjournal_title
Neurobiology of agingauthors
Francelle L,Galvan L,Gaillard MC,Petit F,Bernay B,Guillermier M,Bonvento G,Dufour N,Elalouf JM,Hantraye P,Déglon N,de Chaldée M,Brouillet Edoi
10.1016/j.neurobiolaging.2014.11.014subject
Has Abstractpub_date
2015-03-01 00:00:00pages
1601.e7-16issue
3eissn
0197-4580issn
1558-1497pii
S0197-4580(14)00785-4journal_volume
36pub_type
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journal_title:Neurobiology of aging
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journal_title:Neurobiology of aging
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journal_title:Neurobiology of aging
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doi:10.1016/0197-4580(81)90004-x
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journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/j.neurobiolaging.2004.09.001
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pub_type: 杂志文章
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journal_title:Neurobiology of aging
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