Abstract：
:Raising insulin acutely in the periphery and in brain improves verbal memory. Intranasal insulin administration, which raises insulin acutely in the CNS without raising plasma insulin levels, provides an opportunity to determine whether these effects are mediated by central insulin or peripheral processes. Based on prior research with intravenous insulin, we predicted that the treatment response would differ between subjects with (epsilon4+) and without (epsilon4-) the APOE-epsilon4 allele. On separate mornings, 26 memory-impaired subjects (13 with early Alzheimer's disease and 13 with amnestic mild cognitive impairment) and 35 normal controls each underwent three intranasal treatment conditions consisting of saline (placebo) or insulin (20 or 40 IU). Cognition was tested 15 min post-treatment, and blood was acquired at baseline and 45 min after treatment. Intranasal insulin treatment did not change plasma insulin or glucose levels. Insulin treatment facilitated recall on two measures of verbal memory in memory-impaired epsilon4- adults. These effects were stronger for memory-impaired epsilon4- subjects than for memory-impaired epsilon4+ subjects and normal adults. Unexpectedly, memory-impaired epsilon4+ subjects showed poorer recall following insulin administration on one test of memory. These findings suggest that intranasal insulin administration may have therapeutic benefit without the risk of peripheral hypoglycemia and provide further evidence for apolipoprotein E (APOE) related differences in insulin metabolism.
journal_name
Neurobiol Agingjournal_title
Neurobiology of agingauthors
Reger MA,Watson GS,Frey WH 2nd,Baker LD,Cholerton B,Keeling ML,Belongia DA,Fishel MA,Plymate SR,Schellenberg GD,Cherrier MM,Craft Sdoi
10.1016/j.neurobiolaging.2005.03.016subject
Has Abstractpub_date
2006-03-01 00:00:00pages
451-8issue
3eissn
0197-4580issn
1558-1497pii
S0197-4580(05)00080-1journal_volume
27pub_type
杂志文章abstract：:Recent findings seem to converge towards a unified hypothesis trying to relate Down's syndrome (DS), trisomy 21 and Alzheimer's disease (AD). The majority of DS individuals develop neuropathological characteristics of AD by the age of 40. Previous cytogenetic studies performed by us showed an increased frequency of an...
journal_title：Neurobiology of aging
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journal_title：Neurobiology of aging
pub_type： 杂志文章
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更新日期：1995-01-01 00:00:00
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journal_title：Neurobiology of aging
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journal_title：Neurobiology of aging
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journal_title：Neurobiology of aging
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journal_title：Neurobiology of aging
pub_type： 杂志文章
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更新日期：1988-09-01 00:00:00
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journal_title：Neurobiology of aging
pub_type： 杂志文章
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更新日期：2016-01-01 00:00:00
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journal_title：Neurobiology of aging
pub_type： 杂志文章
doi：10.1016/S0197-4580(03)00093-9
更新日期：2004-03-01 00:00:00
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journal_title：Neurobiology of aging
pub_type： 杂志文章,评审
doi：10.1016/j.neurobiolaging.2005.04.014
更新日期：2006-08-01 00:00:00
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journal_title：Neurobiology of aging
pub_type： 杂志文章
doi：10.1016/j.neurobiolaging.2008.05.023
更新日期：2010-04-01 00:00:00
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journal_title：Neurobiology of aging
pub_type： 杂志文章
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更新日期：2016-10-01 00:00:00
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pub_type： 杂志文章
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journal_title：Neurobiology of aging
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更新日期：2016-05-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Neurobiology of aging
pub_type： 杂志文章
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更新日期：2009-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：1999-11-01 00:00:00
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journal_title：Neurobiology of aging
pub_type： 杂志文章
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更新日期：1982-01-01 00:00:00
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journal_title：Neurobiology of aging
pub_type： 杂志文章
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更新日期：2018-02-01 00:00:00
