No association of Tachykinin receptor 2 (TACR2) polymorphisms with Alzheimer's disease.

abstract：:In order to investigate inflammation and apoptosis in Creutzfeldt-Jakob disease (CJD) patients, we analyzed astrocytes, microglia and apoptotic neurons in brain and IL-1beta in cerebrospinal fluid (CSF). Our results showed increased numbers of astrocytes in CJD and increased numbers of microglia and apoptotic neurons ...

journal_title：Neurobiology of aging

authors： Van Everbroeck B,Dewulf E,Pals P,Lübke U,Martin JJ,Cras P

更新日期：2002-01-01 00:00:00

abstract：:This paper reports a series of experiments that assessed learning and memory performance in aged rats from a neuropsychological perspective. Relative to young adults, old rats displayed rapid rates of forgetting, increased susceptibility to interference, and poor long-term recall of specific experiences. There were no...

journal_title：Neurobiology of aging

authors： Winocur G

更新日期：1988-09-01 00:00:00

abstract：:Middle-aged and aged rats received dorsal hippocampal lesions before performance was evaluated on the radial-arm maze. The maze task contained simultaneous spatial working memory and visually cued reference memory components. Both middle-aged and aged rats that received lesions committed more errors of both types than...

journal_title：Neurobiology of aging

authors： Ward MT,Stoelzel CR,Markus EJ

更新日期：1999-07-01 00:00:00

abstract：:beta A4 peptide (beta AP) accumulates in amyloid plaques of Alzheimer's disease and may contribute to neuronal degeneration. Conflicting observations have been reported regarding the direct in vitro and in vivo neurotoxicity of beta AP. We have assessed in vitro beta AP toxicity in high density primary rat hippocampal...

journal_title：Neurobiology of aging

authors： May PC,Gitter BD,Waters DC,Simmons LK,Becker GW,Small JS,Robison PM

更新日期：1992-09-01 00:00:00

abstract：:Diabetes may adversely affect cognitive function and, conversely, caloric restriction (CR) increases longevity and improves memory. To shed light on the unknown underlying mechanisms involved in these observations, we examined the effects of CR on serum metabolic parameters and hippocampal protein expression in the ob...

journal_title：Neurobiology of aging

authors： Jeon BT,Heo RW,Jeong EA,Yi CO,Lee JY,Kim KE,Kim H,Roh GS

更新日期：2016-08-01 00:00:00

abstract：:While aged monkeys of several species show cerebral amyloid deposition in senile plaques and blood vessels similar to that seen in human aging and Alzheimer's disease (AD), studies of great apes have been limited. Using histological and immunohistochemical methods, we examined the brains of four orangutans aged 10, 28...

journal_title：Neurobiology of aging

authors： Gearing M,Tigges J,Mori H,Mirra SS

更新日期：1997-03-01 00:00:00

abstract：:The H1 MAPT haplotype in the 17q21 chromosomal region has been associated with several neurodegenerative diseases. Some reports have suggested that there is an association between genetic variants within the H1 haplotype with Parkinson's disease (PD), progressive supranuclear palsy (PSP) and corticobasal degeneration ...

journal_title：Neurobiology of aging

authors： Ezquerra M,Pastor P,Gaig C,Vidal-Taboada JM,Cruchaga C,Muñoz E,Martí MJ,Valldeoriola F,Aguilar M,Calopa M,Hernandez-Vara J,Tolosa E

更新日期：2011-03-01 00:00:00

abstract：:We report that a peripheral injection of Escherichia coli produces both anterograde and retrograde amnesia in 24 month old, but not 3 month old rats for memories that depend on the hippocampus, that is, memory of context, contextual fear, and place learning. The anterograde effect was restricted to measures of long-te...

journal_title：Neurobiology of aging

authors： Barrientos RM,Higgins EA,Biedenkapp JC,Sprunger DB,Wright-Hardesty KJ,Watkins LR,Rudy JW,Maier SF

更新日期：2006-05-01 00:00:00

abstract：:Longitudinal human studies suggest that as we age, sociality provides protective benefits against cognitive decline. However, little is known about the underlying neural mechanisms. Rodent studies, which are ideal for studying cognition, fail to examine the independent effects of social housing while controlling for p...

journal_title：Neurobiology of aging

authors： Templer VL,Wise TB,Heimer-McGinn VR

更新日期：2019-03-01 00:00:00

abstract：:This study modeled predementia Alzheimer's disease clinical trials. Longitudinal data from cognitively normal (CN) and mild cognitive impairment (MCI) participants in the Alzheimer's Disease Neuroimaging Initiative were used to calculate sample size requirements for trials using outcome measures, including the Clinica...

journal_title：Neurobiology of aging

authors： Grill JD,Di L,Lu PH,Lee C,Ringman J,Apostolova LG,Chow N,Kohannim O,Cummings JL,Thompson PM,Elashoff D,Alzheimer's Disease Neuroimaging Initiative.

更新日期：2013-01-01 00:00:00

abstract：:Based on evidence that high Mg2+ counteracts age-related declines in synaptic plasticity, and that aged rat hippocampal neurons exhibit prolonged Ca2+-dependent K+ currents, it is proposed that an underlying cause of altered Ca2+ homeostasis during brain aging may be an increased membrane conductance to Ca2+. An appar...

journal_title：Neurobiology of aging

authors： Landfield PW

更新日期：1987-07-01 00:00:00

abstract：:The mitochondrial theory of aging argues that oxidative stress, caused by mitochondrial DNA mutations, is associated with decreased adenosine triphosphate (ATP) production leading to cellular degeneration. The rate of this degradation is linked to metabolic demand, with the outer retina having the greatest in the body...

journal_title：Neurobiology of aging

authors： Kokkinopoulos I,Colman A,Hogg C,Heckenlively J,Jeffery G

更新日期：2013-02-01 00:00:00

abstract：:Apolipoprotein E (APOE) alleles are associated with longevity in genome-wide scans, with ε4 correlated with shorter life, and ε2 with longer life, than ε3. We hypothesized that rare APOE variants with large individual effects might also contribute to long-term good health. The APOE exons and promoter were resequenced ...

journal_title：Neurobiology of aging

authors： Tindale LC,Leach S,Ushey K,Daley D,Brooks-Wilson AR

更新日期：2014-03-01 00:00:00

abstract：:Oxidative stress has been linked to noise- and drug-induced as well as age-related hearing loss. Antioxidants can attenuate the decline of cochlear structure and function after exposure to noise or drugs, but it is debated as to whether they can protect from age-related hearing loss. In a long-term longitudinal study,...

journal_title：Neurobiology of aging

authors： Sha SH,Kanicki A,Halsey K,Wearne KA,Schacht J

更新日期：2012-05-01 00:00:00

abstract：:Iron is essential for triggering oligodendrocytes to myelinate, however, in gray matter (GM) iron increases with age and is associated with age-related degenerative brain diseases. Women have lower iron levels than men, both in the periphery and in the brain, particularly in white matter (WM), possibly due to iron los...

journal_title：Neurobiology of aging

authors： Tishler TA,Raven EP,Lu PH,Altshuler LL,Bartzokis G

更新日期：2012-09-01 00:00:00

abstract：:The ability to perceive and produce speech undergoes important changes in late adulthood. The goal of the present study was to characterize functional and structural age-related differences in the cortical network that support speech perception and production, using magnetic resonance imaging, as well as the relations...

journal_title：Neurobiology of aging

authors： Tremblay P,Dick AS,Small SL

更新日期：2013-08-01 00:00:00

abstract：:Posterior cortical atrophy (PCA) is an understudied visual impairment syndrome most often due to "posterior Alzheimer's disease (AD)" pathology. Case studies detected mutations in PSEN1, PSEN2, GRN, MAPT, and PRNP in subjects with clinical PCA. To detect the frequency and spectrum of mutations in known dementia genes ...

journal_title：Neurobiology of aging

authors： Carrasquillo MM,Barber I,Lincoln SJ,Murray ME,Camsari GB,Khan QUA,Nguyen T,Ma L,Bisceglio GD,Crook JE,Younkin SG,Dickson DW,Boeve BF,Graff-Radford NR,Morgan K,Ertekin-Taner N

更新日期：2016-01-01 00:00:00

abstract：:Adults with Down syndrome (DS) are at high risk for developing Alzheimer's disease after the age of 40 years. To detect white matter (WM) changes in the brain linked to dementia, fractional anisotropy (FA) from diffusion tensor imaging was used. We hypothesized that adults with DS without dementia (DS n = 10), DS with...

journal_title：Neurobiology of aging

authors： Powell D,Caban-Holt A,Jicha G,Robertson W,Davis R,Gold BT,Schmitt FA,Head E

更新日期：2014-07-01 00:00:00

abstract：:The basal forebrain (BF) cholinergic system is selectively vulnerable in human brain diseases, while the cholinergic groups in the upper pons of the brainstem (BS) resist neurodegeneration. Cholinergic neurons (200 per region per animal) were laser-microdissected from five young (8 months) and five aged (24 months) F3...

journal_title：Neurobiology of aging

authors： Baskerville KA,Kent C,Personett D,Lai WR,Park PJ,Coleman P,McKinney M

更新日期：2008-12-01 00:00:00

abstract：:Visual short-term memory (vSTM) is a cognitive resource that declines with age. This study investigated whether electroencephalography (EEG) correlates of vSTM vary with cognitive development over individuals' lifespan. We measured vSTM performance and EEG in a lateralized whole-report task in a healthy birth cohort, ...

journal_title：Neurobiology of aging

authors： Wiegand I,Lauritzen MJ,Osler M,Mortensen EL,Rostrup E,Rask L,Richard N,Horwitz A,Benedek K,Vangkilde S,Petersen A

更新日期：2018-02-01 00:00:00

abstract：:The current study describes both Abeta and tau abnormalities that accumulate in the brains of aged (16-21 years), but not young (<4 years) clinically characterized cats. Diffuse plaques that were morphologically different from what is typically observed in the human brain could be detected with 4G8 (Abeta17-24) or an ...

journal_title：Neurobiology of aging

authors： Head E,Moffat K,Das P,Sarsoza F,Poon WW,Landsberg G,Cotman CW,Murphy MP

更新日期：2005-05-01 00:00:00

abstract：:Mitophagy and mitochondrial biogenesis are 2 pathways that regulate mitochondrial content and metabolism maintaining cellular homeostasis. The imbalance between these opposing processes impairs mitochondrial function and is suggested to be the pathophysiological basis of a variety of neurodegenerative diseases and agi...

journal_title：Neurobiology of aging

authors： Xiong H,Chen S,Lai L,Yang H,Xu Y,Pang J,Su Z,Lin H,Zheng Y

更新日期：2019-07-01 00:00:00

abstract：:Parkinson's disease (PD) is a progressive neurodegenerative disease with typical motor symptoms due to the preferential loss of midbrain dopaminergic (mDA) neurons in the Substantia nigra pars compacta. Several proteins of the homeodomain family are crucial for the development of mDA neurons. These proteins remain exp...

journal_title：Neurobiology of aging

authors： Fuchs J,Mueller JC,Lichtner P,Schulte C,Munz M,Berg D,Wüllner U,Illig T,Sharma M,Gasser T

更新日期：2009-05-01 00:00:00

abstract：:The study aimed to evaluate the effects of noninvasive brain stimulation on cognitive function in healthy older adults and patients with Alzheimer's disease. A comprehensive literature search was performed on noninvasive stimulation studies published from January 1990 to November 2014 in Pubmed and Web of Science. Fou...

journal_title：Neurobiology of aging

authors： Hsu WY,Ku Y,Zanto TP,Gazzaley A

更新日期：2015-08-01 00:00:00

abstract：:In the axon terminals of the locus coeruleus (LC) neurons, a high level of axonal branching was occurred in the middle-aged brain, and the increased branching was maintained in the aged brain. In the present study, we hypothesized that neurotrophic support is necessary for the morphological age-related changes seen in...

journal_title：Neurobiology of aging

authors： Matsunaga W,Shirokawa T,Isobe K

更新日期：2004-03-01 00:00:00

abstract：:Aggregates of hyperphosphorylated tau protein are a pathological hallmark of Alzheimer's disease (AD). The origin of AD is multifactorial, and many metabolic disorders originating from overconsumption of fat, cholesterol, and sugar are associated with higher risk of AD later in life. However, the effects of fat, chole...

journal_title：Neurobiology of aging

authors： Gratuze M,Julien J,Morin F,Calon F,Hébert SS,Marette A,Planel E

更新日期：2016-11-01 00:00:00

abstract：:At early stages of Alzheimer's disease (AD), soluble amyloid beta (Aβ) accumulates in brain while microglia are in resting state. Microglia can recognize Aβ long after formation of plaques and release neurotoxic mediators. We examined impact of early minor activation of microglia by Toll-like receptors (TLRs) 2 and 4 ...

journal_title：Neurobiology of aging

authors： Pourbadie HG,Sayyah M,Khoshkholgh-Sima B,Choopani S,Nategh M,Motamedi F,Shokrgozar MA

更新日期：2018-10-01 00:00:00

abstract：:In humans, action errors and perceptual novelty elicit activity in a shared frontostriatal brain network, allowing them to adapt their ongoing behavior to such unexpected action outcomes. Healthy and pathologic aging reduces the integrity of white matter pathways that connect individual hubs of such networks and can i...

journal_title：Neurobiology of aging

authors： Wessel JR,Ullsperger M,Obrig H,Villringer A,Quinque E,Schroeter ML,Bretschneider KJ,Arelin K,Roggenhofer E,Frisch S,Klein TA

更新日期：2016-02-01 00:00:00

abstract：:The hippocampal perforant pathway originates in the entorhinal cortex (ERC) and terminates in the outer molecular layer of the dentate gyrus (DG). To compare the effects of normal aging and Alzheimer's disease (AD) on the elements of the perforant pathway, we compared relative perikaryal numbers (determined by countin...

journal_title：Neurobiology of aging

authors： Lippa CF,Hamos JE,Pulaski-Salo D,DeGennaro LJ,Drachman DA

更新日期：1992-05-01 00:00:00

abstract：:An association between semicarbazide-sensitive amine oxidase (SSAO) and cerebral amyloid angiopathy (CAA) related to Alzheimer's disease (AD) has been largely postulated. Increased SSAO activity and expression have been detected in cerebrovascular tissue and plasma of AD patients, colocalizing with cerebrovascular amy...

journal_title：Neurobiology of aging

authors： Solé M,Miñano-Molina AJ,Unzeta M

更新日期：2015-02-01 00:00:00