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beta-Amyloid peptide in vitro toxicity: lot-to-lot variability.

Abstract：

:beta A4 peptide (beta AP) accumulates in amyloid plaques of Alzheimer's disease and may contribute to neuronal degeneration. Conflicting observations have been reported regarding the direct in vitro and in vivo neurotoxicity of beta AP. We have assessed in vitro beta AP toxicity in high density primary rat hippocampal cultures and found marked lot-to-lot differences in the neurotoxic properties of beta AP. One lot of beta AP from a commercial supplier resulted in significant direct neurotoxicity at 10 microM, while 2 other lots from the same supplier were essentially nontoxic. Three additional lots of beta AP from unrelated sources were also nontoxic at 10 microM. Initial biochemical characterization has not yet revealed any marked differences among the various lots of beta AP. Low levels of endotoxin (ca., 1 EU/ml) were detected in several beta AP preparations but did not correlate with neurotoxicity. Our observation that lot-to-lot variability of beta AP occurred even under identical in vitro culture conditions may account for part of the present controversy in this area.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

May PC,Gitter BD,Waters DC,Simmons LK,Becker GW,Small JS,Robison PM

doi

10.1016/0197-4580(92)90064-5

subject

Has Abstract

pub_date

1992-09-01 00:00:00

pages

605-7

issue

5

eissn

0197-4580

issn

1558-1497

pii

0197-4580(92)90064-5

journal_volume

13

pub_type

杂志文章

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