Abstract:
:Poor cognitive performance of elderly individuals with low educational attainment is often difficult to interpret in dementia evaluation. Lack of education, as well as dementia, is often associated with poor cognitive test performance. To elucidate the underlying structural change of low cognitive performance in elderly individuals with low educational attainment, this study examined the relationship between low cognitive performance (LCP) and brain volumes, especially regions vulnerable to Alzheimer's disease, in nondemented elderly Koreans. Individuals with LCP (n=14) were matched on age and education with individuals with normal cognitive performance (n=14). The two groups were compared on the MR-based volumetric measures in the hippocampus, the entorhinal cortex, the amygdala, the temporal lobe, the frontal lobe, the cerebrum, and the intracranial cavity. Intracranial volume (p<.05) and absolute hippocampus (p<.05) and frontal lobe volumes (p<.05) were significantly reduced in individuals with LCP. Normalized volumes of the hippocampus and the frontal lobe did not differ in the two cognitive performance groups. ICV was associated with the K-DRS scores. General cognitive functioning of the LCP individuals, measured with the Korean version of the DRS, did not deteriorate in the 1- or 2-year follow-up cognitive tests. LCP in a nondemented elderly population with limited education appears to be associated with stable lower intelligence rather than increased risk for dementia of the Alzheimer's type.
journal_name
Neurobiol Agingjournal_title
Neurobiology of agingauthors
Chey J,Na DG,Tae WS,Ryoo JW,Hong SBdoi
10.1016/j.neurobiolaging.2005.07.020subject
Has Abstractpub_date
2006-09-01 00:00:00pages
1269-79issue
9eissn
0197-4580issn
1558-1497pii
S0197-4580(05)00225-3journal_volume
27pub_type
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journal_title:Neurobiology of aging
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journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/s0197-4580(99)00092-5
更新日期:1999-09-01 00:00:00
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journal_title:Neurobiology of aging
pub_type: 杂志文章
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journal_title:Neurobiology of aging
pub_type: 杂志文章
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更新日期:2016-04-01 00:00:00
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journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/j.neurobiolaging.2006.06.006
更新日期:2007-09-01 00:00:00
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journal_title:Neurobiology of aging
pub_type: 杂志文章
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journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/s0197-4580(99)00019-6
更新日期:1999-01-01 00:00:00
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journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/0197-4580(91)90091-w
更新日期:1991-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0197-4580(83)90057-x
更新日期:1983-04-01 00:00:00
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journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/j.neurobiolaging.2019.01.005
更新日期:2019-05-01 00:00:00
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journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/s0197-4580(01)00339-6
更新日期:2002-07-01 00:00:00
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journal_title:Neurobiology of aging
pub_type: 杂志文章
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journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/j.neurobiolaging.2013.08.005
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pub_type: 杂志文章
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journal_title:Neurobiology of aging
pub_type: 杂志文章
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更新日期:1993-03-01 00:00:00
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journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/j.neurobiolaging.2004.12.009
更新日期:2006-01-01 00:00:00
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journal_title:Neurobiology of aging
pub_type: 杂志文章
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更新日期:2003-10-01 00:00:00
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journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/j.neurobiolaging.2010.12.002
更新日期:2012-02-01 00:00:00
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journal_title:Neurobiology of aging
pub_type: 杂志文章,评审
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更新日期:1997-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.neurobiolaging.2017.12.029
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journal_title:Neurobiology of aging
pub_type: 杂志文章
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更新日期:2014-09-01 00:00:00
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journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/j.neurobiolaging.2005.10.021
更新日期:2006-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:1996-09-01 00:00:00