Young and older good learners have higher levels of brain nicotinic receptor binding.


:Neuronal alphabeta heteromeric and alpha7 homomeric nicotinic acetylcholine receptors (nAChRs) were compared in 4- and 27-month rabbits selected for learning proficiency. Sixty 4- and 60 27-month rabbits received the alpha7 nAChR agonist (MEM-3389), galantamine, or vehicle during training in trace eyeblink classical conditioning. Brain tissue from the best and worst young and older learners was analyzed with radioligand binding. Vehicle-treated 4- and 27-month good learners had higher alphabeta heteromeric nAChR binding in hippocampus and temporal-parietal cortex than poor learners, and this result was replicated in both age groups of rabbits treated with galantamine. Results indicate that anatomically more numerous nAChRs or functional activation of a greater number of nAChRs may characterize animals demonstrating optimal learning. During normal aging the expression of high-affinity binding sites declines. Age-related changes in the expression of hippocampal alphabeta heteromeric nAChRs may account for some of the documented age-related impairment in learning. However, individual differences in alphabeta heteromeric nAChRs also exist early in life, as better learning in 4-month rabbits was associated with significantly higher binding.


Neurobiol Aging


Neurobiology of aging


Woodruff-Pak DS,Lehr MA,Li JG,Liu-Chen LY




Has Abstract


2010-06-01 00:00:00














  • Brain cholinergic dysfunction and memory in aged rats.

    abstract::Age related alterations in mnemonic ability and in the functional status of muscarinic receptors were evaluated and compared to biochemical measures of pre and post-synaptic cholinergic functioning. Retention of a single trial passive avoidance task was considerably disturbed as a function of aging. The functional sta...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Lippa AS,Pelham RW,Beer B,Critchett DJ,Dean RL,Bartus RT

    更新日期:1980-07-01 00:00:00

  • Neuropathological criteria for the diagnosis of Alzheimer's disease.

    abstract::The definitive diagnosis of Alzheimer's disease (AD) is made at autopsy by the presence of abundant neuritic plaques (NP) and neurofibrillary tangles (NFT) in the neocortex, entorhinal cortex, and hippocampus. The two criteria most frequently used by neuropathologists for the diagnosis of AD over the past 12 years are...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章,评审


    authors: Markesbery WR

    更新日期:1997-07-01 00:00:00

  • Estimating sample sizes for predementia Alzheimer's trials based on the Alzheimer's Disease Neuroimaging Initiative.

    abstract::This study modeled predementia Alzheimer's disease clinical trials. Longitudinal data from cognitively normal (CN) and mild cognitive impairment (MCI) participants in the Alzheimer's Disease Neuroimaging Initiative were used to calculate sample size requirements for trials using outcome measures, including the Clinica...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Grill JD,Di L,Lu PH,Lee C,Ringman J,Apostolova LG,Chow N,Kohannim O,Cummings JL,Thompson PM,Elashoff D,Alzheimer's Disease Neuroimaging Initiative.

    更新日期:2013-01-01 00:00:00

  • Genetic variations in the CLU and PICALM genes are associated with cognitive function in the oldest old.

    abstract::Recently, two large, and independent genome wide association studies of late-onset Alzheimer's disease (AD) established association with the same rs11136000 variation in the clusterin (CLU) gene. In addition, one variation, rs3851179, in the phosphatidylinositol binding clathrin assembly protein (PICALM) gene and one ...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Mengel-From J,Christensen K,McGue M,Christiansen L

    更新日期:2011-03-01 00:00:00

  • Immunologic and tissue culture approaches to the neurobiology of aging.

    abstract::The neurobiology of aging continues to attract scientists and techniques from the more fundamental disciplines, as witness the great strides now being made from molecular genetic approaches to Alzheimer's disease. The present report is a commentary on reviews of immune mechanisms and tissue culture methods applied to ...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Rogers J,Rovigatti U

    更新日期:1988-09-01 00:00:00

  • Place cells of aged rats in two visually identical compartments.

    abstract::Aged rats perform poorly on spatial learning tasks, a cognitive impairment which has been linked to the failure of hippocampal networks to fully encode changes in the external environment [Barnes CA, Suster MS, Shen J, McNaughton BL. Multistability of cognitive maps in the hippocampus of old rats. Nature 1997;388(6639...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Wilson IA,Ikonen S,Gurevicius K,McMahan RW,Gallagher M,Eichenbaum H,Tanila H

    更新日期:2005-07-01 00:00:00

  • Distortions in rest-activity rhythm in aging relate to white matter hyperintensities.

    abstract::Distortions in the rest-activity rhythm in aging are commonly observed. Neurodegenerative changes of the suprachiasmatic nucleus have been proposed to underlie this disrupted rhythm. However, based on previous studies, it can be proposed that white matter hyperintensities (WMH) may also play a role in the altered rest...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Oosterman J,van Harten B,Vogels R,Gouw A,Weinstein H,Scheltens P,Scherder E

    更新日期:2008-08-01 00:00:00

  • Transcriptional profiling of Alzheimer blood mononuclear cells by microarray.

    abstract::We evaluated pathomechanisms and systemic manifestations of Alzheimer disease (AD), an aging-related dementing neurodegenerative disorder, by expression profiling. Blood mononuclear cell (BMC) transcriptomes of sporadic AD subjects and aged-matched normal elderly controls (NEC) were compared using the human NIA microa...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Maes OC,Xu S,Yu B,Chertkow HM,Wang E,Schipper HM

    更新日期:2007-12-01 00:00:00

  • Candidate gene analysis for Alzheimer's disease in adults with Down syndrome.

    abstract::Individuals with Down syndrome (DS) overexpress many genes on chromosome 21 due to trisomy and have high risk of dementia due to the Alzheimer's disease (AD) neuropathology. However, there is a wide range of phenotypic differences (e.g., age at onset of AD, amyloid β levels) among adults with DS, suggesting the import...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Lee JH,Lee AJ,Dang LH,Pang D,Kisselev S,Krinsky-McHale SJ,Zigman WB,Luchsinger JA,Silverman W,Tycko B,Clark LN,Schupf N

    更新日期:2017-08-01 00:00:00

  • Usual vs. successful aging: some notes on experiential factors.

    abstract::A common analogy to aging is that of a boulder being worn down to rubble by the unremitting onslaught of time. In contrast, Swaab's "use it or lose it" concept is important because it emphasizes some positive consequences of experience. For example, early exposure to complex experience may offer some protection from "...

    journal_title:Neurobiology of aging

    pub_type: 评论,杂志文章


    authors: Black JE,Isaacs KR,Greenough WT

    更新日期:1991-07-01 00:00:00

  • Rat tail artery norepinephrine release: age and effect of mitochondrial blockade.

    abstract::An age-related increase in stimulation-evoked fractional norepinephrine release has been demonstrated in tail artery of Fischer-344 rats from 6 to 20 months of age. Previous studies have ruled out alterations in function of uptake mechanisms, metabolism, or feedback via prejunctional alpha-2 adrenoceptors, suggesting ...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Tsai H,Duckles SP,Buchholz J

    更新日期:1995-09-01 00:00:00

  • Aging-induced microbleeds of the mouse thalamus compared to sensorimotor and memory defects.

    abstract::The aim of this study is to investigate the relationship between aging and brain vasculature health. Three groups of mice, 3, 17-18, and 24 months, comparable to young adult, middle age, and old human were studied. Prussian blue histology and fast imaging with steady precession T2∗-weighted magnetic resonance imaging ...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Wang Y,Taylor E,Zikopoulos B,Seta F,Huang N,Hamilton JA,Kantak KM,Morgan KG

    更新日期:2020-12-09 00:00:00

  • White matter loss in healthy ageing: a postmortem analysis.

    abstract::Age-related brain changes are widely documented. Because of differences in measurement methods and case selection, the reported effects of age on regional grey and white matter brain volumes, however, are much more pronounced and widespread in neuroimaging than in postmortem studies. Consequently, the magnitude of the...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Piguet O,Double KL,Kril JJ,Harasty J,Macdonald V,McRitchie DA,Halliday GM

    更新日期:2009-08-01 00:00:00

  • Andrographolide recovers cognitive impairment in a natural model of Alzheimer's disease (Octodon degus).

    abstract::The social species Octodon degus (degu) is the only wild-type South American rodent that develops Alzheimer's-like pathology with age. Here, we evaluated the ability of a natural product (Andrographolide, ANDRO), a diterpene of the labdane family obtained from the Asian plant Andrographis paniculata, to recover the co...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Rivera DS,Lindsay C,Codocedo JF,Morel I,Pinto C,Cisternas P,Bozinovic F,Inestrosa NC

    更新日期:2016-10-01 00:00:00

  • Genetics of early-onset Parkinson's disease in Finland: exome sequencing and genome-wide association study.

    abstract::Several genes and risk factors are associated with Parkinson's disease (PD). Although many of the genetic markers belong to a common pathway, a unifying pathogenetic mechanism is yet to be found. Also, missing heritability analyses have estimated that only part of the genetic influence contributing to PD has been foun...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Siitonen A,Nalls MA,Hernández D,Gibbs JR,Ding J,Ylikotila P,Edsall C,Singleton A,Majamaa K

    更新日期:2017-05-01 00:00:00

  • Everyday memory deficits in very mild Alzheimer's disease.

    abstract::Memory complaints of patients sometimes are not verified via standard cognitive testing. Acquisition of information in everyday life requires memorization in complex three-dimensional environments. The authors mimicked this with a photorealistic virtual environment (VE). Memory for verbal material and spatial scenery ...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Widmann CN,Beinhoff U,Riepe MW

    更新日期:2012-02-01 00:00:00

  • Comparison of methods for measuring longitudinal brain change in cognitive impairment and dementia.

    abstract:PURPOSE:The goal of this project was to compare MRI measures of hippocampal, entorhinal cortex (ERC), and whole brain longitudinal change in cognitively normal elderly controls (C), non-demented subjects with cognitive impairment (CI), and demented (D) subjects. METHODS:16 C, 6 CI, and 7 D subjects of comparable age w...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Cardenas VA,Du AT,Hardin D,Ezekiel F,Weber P,Jagust WJ,Chui HC,Schuff N,Weiner MW

    更新日期:2003-07-01 00:00:00

  • Acetyl-L-carnitine: behavioral, electrophysiological, and neurochemical effects.

    abstract::Aged rats were chronically administered acetyl-L-carnitine (AC) for 10 months. During this period they were tested on learning and sensorimotor tasks and were then subsequently tested electrophysiologically to assess induction and decay rates of long-term synaptic enhancement (LTE) in the hippocampus. Four groups were...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Davis S,Markowska AL,Wenk GL,Barnes CA

    更新日期:1993-01-01 00:00:00

  • Neural correlates of age-related decline and compensation in visual attention capacity.

    abstract::We identified neural correlates of declined and preserved basic visual attention functions in aging individuals based on Bundesen "Theory of Visual Attention". In an interindividual difference approach, we contrasted electrophysiology of higher- and lower-performing younger and older participants. In both age groups, ...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Wiegand I,Töllner T,Dyrholm M,Müller HJ,Bundesen C,Finke K

    更新日期:2014-09-01 00:00:00

  • Modulation of miR-34a/SIRT1 signaling protects cochlear hair cells against oxidative stress and delays age-related hearing loss through coordinated regulation of mitophagy and mitochondrial biogenesis.

    abstract::Mitophagy and mitochondrial biogenesis are 2 pathways that regulate mitochondrial content and metabolism maintaining cellular homeostasis. The imbalance between these opposing processes impairs mitochondrial function and is suggested to be the pathophysiological basis of a variety of neurodegenerative diseases and agi...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Xiong H,Chen S,Lai L,Yang H,Xu Y,Pang J,Su Z,Lin H,Zheng Y

    更新日期:2019-07-01 00:00:00

  • Omegaconotoxin binding decreases in aged rat brain.

    abstract::Omegaconotoxin binding was studied in young (3 months) and old (24 months) male Sprague-Dawley rats. In both groups omegaconotoxin binding displayed high affinity, was specific and saturable. The age-related changes are mainly a decrease in the Bmax in striatum and cortex (-29% and -31%, respectively). Binding paramet...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Moresco RM,Govoni S,Battaini F,Trivulzio S,Trabucchi M

    更新日期:1990-07-01 00:00:00

  • The role of cytokines, astrocytes, microglia and apoptosis in Creutzfeldt-Jakob disease.

    abstract::In order to investigate inflammation and apoptosis in Creutzfeldt-Jakob disease (CJD) patients, we analyzed astrocytes, microglia and apoptotic neurons in brain and IL-1beta in cerebrospinal fluid (CSF). Our results showed increased numbers of astrocytes in CJD and increased numbers of microglia and apoptotic neurons ...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Van Everbroeck B,Dewulf E,Pals P,Lübke U,Martin JJ,Cras P

    更新日期:2002-01-01 00:00:00

  • Aging alters envelope representations of speech-like sounds in the inferior colliculus.

    abstract::Hearing impairment in older people is thought to arise from impaired temporal processing in auditory circuits. We used a systems-level (scalp recordings) and a microcircuit-level (extracellular recordings) approach to investigate how aging affects the sensitivity to temporal envelopes of speech-like sounds in rats. Sc...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Parthasarathy A,Herrmann B,Bartlett EL

    更新日期:2019-01-01 00:00:00

  • Age-related vulnerability of pattern separation in C57BL/6J mice.

    abstract::Aging is associated with impaired performance in behavioral pattern separation (PS) tasks based on similarities in object features and in object location. These deficits have been attributed to functional alterations in the dentate gyrus (DG)-CA3 region. Animal studies suggested a role of adult-born DG neurons in PS p...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Cès A,Burg T,Herbeaux K,Héraud C,Bott JB,Mensah-Nyagan AG,Mathis C

    更新日期:2018-02-01 00:00:00

  • The effect of TOMM40 on spatial navigation in amnestic mild cognitive impairment.

    abstract::The very long (VL) poly-T variant at rs10524523 ("523") of the TOMM40 gene may hasten the onset of late-onset Alzheimer's disease (LOAD) and induce more profound cognitive impairment compared with the short (S) poly-T variant. We examined the influence of TOMM40 "523" polymorphism on spatial navigation and its brain s...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Laczó J,Andel R,Vyhnalek M,Matoska V,Kaplan V,Nedelska Z,Lerch O,Gazova I,Moffat SD,Hort J

    更新日期:2015-06-01 00:00:00

  • High incidence of adverse cerebral blood flow responses to spreading depolarization in the aged ischemic rat brain.

    abstract::Spreading depolarizations (SDs) occur spontaneously in the brain after stroke, exacerbate ischemic injury, and thus emerge as a potential target of intervention. Aging predicts worse outcome from stroke; yet, the impact of age on SD evolution is not clear. Cerebral ischemia was induced by bilateral common carotid arte...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Menyhárt Á,Makra P,Szepes BÉ,Tóth OM,Hertelendy P,Bari F,Farkas E

    更新日期:2015-12-01 00:00:00

  • Neurons, glia, and plasticity in normal brain aging.

    abstract::Early manifestations of brain aging have received much less attention than the drastic degeneration of AD and MID. During nonpathological changes of normal aging, brain systems differ in the involvement of neuron loss. Spatial learning can become impaired without evidence for neuron loss, whereas eye-blink conditionin...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章,评审


    authors: Finch CE

    更新日期:2003-05-01 00:00:00

  • Transcriptome-wide piRNA profiling in human brains of Alzheimer's disease.

    abstract::Discovered in the brains of multiple animal species, piRNAs may contribute to the pathogenesis of neuropsychiatric illnesses. The present study aimed to identify brain piRNAs across transcriptome that are associated with Alzheimer's disease (AD). Prefrontal cortical tissues of 6 AD cases and 6 controls were examined f...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Qiu W,Guo X,Lin X,Yang Q,Zhang W,Zhang Y,Zuo L,Zhu Y,Li CR,Ma C,Luo X

    更新日期:2017-09-01 00:00:00

  • Age-related neurofilament phosphorylation in normal human brains.

    abstract::An age-related phosphorylation of the 200kD neurofilament protein (NF200) has been observed in the axons of cerebellar basket cells of normal human fixed brain tissue from individuals older than 60 years, but not in younger individuals. The probe for this study was the monoclonal antibody SMI-34 which detects a phosph...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Blanchard BJ,Ingram VM

    更新日期:1989-05-01 00:00:00

  • Fresh evidence for major brain gangliosides as a target for the treatment of Alzheimer's disease.

    abstract::Although it was suggested that gangliosides play an important role in the binding of amyloid fragments to neuronal cells, the exact role of gangliosides in Alzheimer's disease (AD) pathology remains unclear. To understand the role of gangliosides in AD pathology in vivo, we crossed st3gal5-deficient (ST3-/-) mice that...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Dukhinova M,Veremeyko T,Yung AWY,Kuznetsova IS,Lau TYB,Kopeikina E,Chan AML,Ponomarev ED

    更新日期:2019-05-01 00:00:00