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Accelerated aging of the putamen in men but not in women.

Abstract：

:Age-related structural brain changes have been demonstrated repeatedly but data on the effect of gender on age-related structural brain changes are conflicting. Using high-resolution T1-weighted magnetic resonance imaging and voxel-based morphometry, we examined a population of 133 healthy adults (women, 73; men, 60; age range, 29-80 years) focusing on differential aging between men and women (i.e., interaction of age and gender). Compared to women, men showed accelerated age-related gray matter (GM) loss in the posterior putamen. Our data may constitute the structural substrate for age-related differences in motor function between men and women such as the higher incidence and earlier onset of Parkinson's disease in men.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

Nunnemann S,Wohlschläger AM,Ilg R,Gaser C,Etgen T,Conrad B,Zimmer C,Mühlau M

doi

10.1016/j.neurobiolaging.2007.05.016

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

147-51

issue

1

eissn

0197-4580

issn

1558-1497

pii

S0197-4580(07)00231-X

journal_volume

30

pub_type

杂志文章

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