Abstract:
:A recent genome-wide association study of patients with essential tremor (ET) from Germany has nominated SLC1A2 rs3794087 as a novel risk factor for disease. This association was independently replicated in the Chinese population, albeit with an opposite direction of effect. To further define the role of SLC1A2 in ET, we genotyped rs3794087 in a North American series consisting of 1347 patients with ET and controls. Statistical analysis did not identify significant differences in genotype or allele frequencies between healthy controls and patients with ET (p > 0.36). These findings therefore do not support a role for SLC1A2 rs3794087 in susceptibility to ET in the North American population. Further studies in ethnically distinct populations of patients with ET are necessary to understand whether genetic variability in SLC1A2 affects disease risk for ET.
journal_name
Neurobiol Agingjournal_title
Neurobiology of agingauthors
Ross JP,Rayaprolu S,Bernales CQ,Soto-Ortolaza AI,van Gerpen J,Uitti RJ,Wszolek ZK,Rajput A,Rajput AH,Rajput ML,Ross OA,Vilariño-Güell Cdoi
10.1016/j.neurobiolaging.2013.09.022subject
Has Abstractpub_date
2014-04-01 00:00:00pages
935.e9-10issue
4eissn
0197-4580issn
1558-1497pii
S0197-4580(13)00424-7journal_volume
35pub_type
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journal_title:Neurobiology of aging
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journal_title:Neurobiology of aging
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