Age-related subsensitivity of cerebellar Purkinje neurons to locally applied beta 1-selective adrenergic agonist.

abstract：:Eyeblink classical conditioning (EBCC) is impared in rabbits and humans during normal aging and severely disrupted in Alzheimer's disease (AD) and older Down's Syndrome patients (called DS/AD). To determine if older rabbit brains developed neuropathological evidence of Alzheimer-like pathology to account for impaired ...

journal_title：Neurobiology of aging

authors： Woodruff-Pak DS,Trojanowski JQ

更新日期：1996-03-01 00:00:00

abstract：:To better understand the role of insulin signaling in the development of Alzheimer's disease (AD), we utilized an animal model (intracerebroventricular injection of streptozotocin-ic-streptozotocin (STZ)) that displays insulin resistance only in the brain and exhibits AD pathology. In this model, deficits in hippocamp...

journal_title：Neurobiology of aging

authors： Shonesy BC,Thiruchelvam K,Parameshwaran K,Rahman EA,Karuppagounder SS,Huggins KW,Pinkert CA,Amin R,Dhanasekaran M,Suppiramaniam V

更新日期：2012-02-01 00:00:00

abstract：:We previously found a selective loss of the brain specific APP-695 transcript in Alzheimer's disease (AD) cortex, which results in a 2.5-fold increase in the APP-751/APP-695 transcript ratio in AD (9). Here we report a similar increase in APP-751/APP-695 mRNA ratio in AD hippocampus. However, the cerebellum had a 6-fo...

journal_title：Neurobiology of aging

authors： Johnson SA,Rogers J,Finch CE

更新日期：1989-11-01 00:00:00

abstract：:The aim of this study is to investigate the relationship between aging and brain vasculature health. Three groups of mice, 3, 17-18, and 24 months, comparable to young adult, middle age, and old human were studied. Prussian blue histology and fast imaging with steady precession T2∗-weighted magnetic resonance imaging ...

journal_title：Neurobiology of aging

authors： Wang Y,Taylor E,Zikopoulos B,Seta F,Huang N,Hamilton JA,Kantak KM,Morgan KG

更新日期：2020-12-09 00:00:00

abstract：:Visual function declines with age. This deterioration results not only from changes in the optical system but also from the functional degradation of the central visual cortex. Although numerous studies have explored the mechanisms of age-related influences on vision, they have failed to acknowledge the significance o...

journal_title：Neurobiology of aging

authors： Wang X,Zhang B,Wang H,Liu J,Xu G,Zhou Y

更新日期：2019-04-01 00:00:00

abstract：:Brain deposits of amyloid beta peptide (Abeta) have been a diagnostic hallmark of Alzheimer's disease (AD) for nearly a century. Recent studies have demonstrated that Abeta is also present in peripheral blood. Here, we present evidence that circulating Abeta42 is subject to complement C3b-dependent adherence to comple...

journal_title：Neurobiology of aging

authors： Rogers J,Li R,Mastroeni D,Grover A,Leonard B,Ahern G,Cao P,Kolody H,Vedders L,Kolb WP,Sabbagh M

更新日期：2006-12-01 00:00:00

abstract：:Macrophages or activated microglia in the subretinal space are considered a hallmark of some retinal pathologies. We investigated the effects of age, pigmentation and CX(3)CR1 deficiency on the accumulation of macrophages/activated microglia in the outer retina of young and old Cx(3)cr1(gfp/gfp) (CX(3)CR1-deficient) o...

journal_title：Neurobiology of aging

authors： Chinnery HR,McLenachan S,Humphries T,Kezic JM,Chen X,Ruitenberg MJ,McMenamin PG

更新日期：2012-08-01 00:00:00

abstract：:Aging produces a loss in a number of behavioral and cognitive functions, including sleep. Hypocaloric diet is one of the few methods that have been shown to retard the effects due to age. However, the effects of such a diet on sleep have never been investigated. In the present study, 21 months old male F344 rats fed a...

journal_title：Neurobiology of aging

authors： Salin-Pascual RJ,Upadhyay U,Shiromani PJ

更新日期：2002-09-01 00:00:00

abstract：:I propose that North American investigators who depend largely on individual external grants would benefit from the creation of regional facilities designed to support studies of aging in transgenic models. In general, academic institutions cannot achieve the most cost effectiveness because their facilities are not de...

journal_title：Neurobiology of aging

authors： Finch CE

更新日期：1999-03-01 00:00:00

abstract：:The adaption of movement to changes in the environment varies across life span. Recent evidence has linked motor adaptation and its reduction with age to differences in "explicit" learning processes. We examine differences in brain structure and cognition underlying motor adaptation in a population-based cohort (n = 3...

journal_title：Neurobiology of aging

authors： Wolpe N,Ingram JN,Tsvetanov KA,Henson RN,Wolpert DM,Cam-CAN.,Rowe JB

更新日期：2020-06-01 00:00:00

abstract：:We investigated whether progranulin plasma levels are predictors of the presence of progranulin gene (GRN) null mutations or of the development of symptoms in asymptomatic at risk members participating in the Genetic Frontotemporal Dementia Initiative, including 19 patients, 64 asymptomatic carriers, and 77 noncarrier...

journal_title：Neurobiology of aging

authors： Galimberti D,Fumagalli GG,Fenoglio C,Cioffi SMG,Arighi A,Serpente M,Borroni B,Padovani A,Tagliavini F,Masellis M,Tartaglia MC,van Swieten J,Meeter L,Graff C,de Mendonça A,Bocchetta M,Rohrer JD,Scarpini E,Genetic FTD I

更新日期：2018-02-01 00:00:00

abstract：:Recent case-control studies reported an association between H. pylori infection and Alzheimer's disease (AD). Our aim was to compare cognitive impairment, neuroinflammation, and cerebrovascular lesion load in a group of AD patients according to their H. pylori status. For the 53 AD patients included, we assessed: clin...

journal_title：Neurobiology of aging

authors： Roubaud-Baudron C,Krolak-Salmon P,Quadrio I,Mégraud F,Salles N

更新日期：2012-05-01 00:00:00

abstract：:Perisynaptic accumulations of amyloid β-protein (Aβ) play a critical role in the synaptic dysfunction underlying the cognitive impairment observed in Alzheimer's disease. The methionine residue at position 35 (Met35) in Aβ is highly subject to oxidation in Alzheimer's disease brains. In hippocampal brain slices we fou...

journal_title：Neurobiology of aging

authors： Ripoli C,Piacentini R,Riccardi E,Leone L,Li Puma DD,Bitan G,Grassi C

更新日期：2013-04-01 00:00:00

abstract：:Chronic circadian disturbance, a condition of desynchronization between endogenous clock and environmental light-dark (LD) cycle, is known to cause adverse physiological changes including mortality. However, it is yet unclear whether these consequences result from disturbance of endogenous clock or condition of the LD...

journal_title：Neurobiology of aging

authors： Park N,Cheon S,Son GH,Cho S,Kim K

更新日期：2012-06-01 00:00:00

abstract：:Oxidative stress has been linked to noise- and drug-induced as well as age-related hearing loss. Antioxidants can attenuate the decline of cochlear structure and function after exposure to noise or drugs, but it is debated as to whether they can protect from age-related hearing loss. In a long-term longitudinal study,...

journal_title：Neurobiology of aging

authors： Sha SH,Kanicki A,Halsey K,Wearne KA,Schacht J

更新日期：2012-05-01 00:00:00

abstract：:The relationship between hematological variables and the ability to perform behaviorally in two learning tests was evaluated in male F344 rats aged 22-24 months. Rats were screened for ability to meet criterion for learning one-way active avoidance in a straight runway task. Rats failing to meet criterion were given n...

journal_title：Neurobiology of aging

authors： Spangler EL,Waggie KS,Rea W,Roberts D,Hengemihle J,Danon D,Ingram DK

更新日期：1995-01-01 00:00:00

abstract：:Several polymorphisms in hepatic lipase (LIPC) are similar to apoE4 because they associate with cholesterol concentrations and, for rs6084, coronary artery disease (CAD). Since apoE4 is also a primary genetic risk factor for late-onset Alzheimer's disease (LOAD), LIPC single nucleotide polymorphisms (SNP)s represent e...

journal_title：Neurobiology of aging

authors： Zhu H,Taylor JW,Bennett DA,Younkin SG,Estus S

更新日期：2008-05-01 00:00:00

abstract：:A study on familial Parkinson disease (PD) described 4 variants in the gene TMEM230 (Chr. 20p13) as the cause of PD. The aim of this study was to test if variants in the TMEM230 gene are associated with PD in 2 independent American European data sets. No variants in the TMEM230 region were found associated with PD, ag...

journal_title：Neurobiology of aging

authors： Ibanez L,Dube U,Budde J,Black K,Medvedeva A,Davis AA,Perlmutter JS,Benitez BA,Cruchaga C

更新日期：2017-08-01 00:00:00

abstract：:The Parkinson's disease (PD)-related inclusion body pathology comprises Lewy bodies (LBs) as well as Lewy neurites (LNs). The distribution and severity of this pathology were investigated in the thalamus of 12 autopsy cases with clinically diagnosed and neuropathologically confirmed PD. The LBs and LNs were visualized...

journal_title：Neurobiology of aging

authors： Rüb U,Del Tredici K,Schultz C,Ghebremedhin E,de Vos RA,Jansen Steur E,Braak H

更新日期：2002-03-01 00:00:00

abstract：:Although important in neurodegeneration, systematic studies of nicotinic acetylcholine receptor expression in normal aging human brains are difficult to perform. We have studied the expression of nicotinic receptor alpha 4-1 and alpha 5 mRNA in the frontal and parietal isocortex of 3- (young adult), 24- (late middle a...

journal_title：Neurobiology of aging

authors： Birtsch C,Wevers A,Traber J,Maelicke A,Bloch W,Schröder H

更新日期：1997-05-01 00:00:00

abstract：:Flavonoids, a group of dietary polyphenols have been shown to possess cognitive health benefits. Epidemiologic evidence suggests that they could play a role in risk reduction in dementia. Amyloid precursor protein processing and the subsequent generation of amyloid beta (Aβ) are central to the pathogenesis of Alzheime...

journal_title：Neurobiology of aging

authors： Cox CJ,Choudhry F,Peacey E,Perkinton MS,Richardson JC,Howlett DR,Lichtenthaler SF,Francis PT,Williams RJ

更新日期：2015-01-01 00:00:00

abstract：:This study investigates the age associated changes in hemorheological properties and cerebral blood flow. Partial correlations indicate that part of the age-dependent decrease in flow velocities can be attributed to a hemorheological decrement resulting in part from enhanced oxidative stress in the aged. A possible li...

journal_title：Neurobiology of aging

authors： Ajmani RS,Metter EJ,Jaykumar R,Ingram DK,Spangler EL,Abugo OO,Rifkind JM

更新日期：2000-03-01 00:00:00

abstract：OBJECTIVE:To investigate whether cognitive function in the spectrum of normal aging to Alzheimer's disease is better reflected in MRI or EEG measures, or a combination of both. METHODS:Cognitive functions were tested in 33 elderly subjects: 10 with probable Alzheimer's disease, 11 with mild cognitive impairment and 12...

journal_title：Neurobiology of aging

authors： van der Hiele K,Vein AA,van der Welle A,van der Grond J,Westendorp RG,Bollen EL,van Buchem MA,van Dijk JG,Middelkoop HA

更新日期：2007-09-01 00:00:00

abstract：:Altered glutamate transport and aberrant EAAT1 expression were shown in Alzheimer's disease (AD) brains. It is presently unknown whether these modifications are a consequence of neurodegeneration or play a pathogenetic role. However, recent findings of decreased glutamate uptake, EAAT1 protein and mRNA in AD platelets...

journal_title：Neurobiology of aging

authors： Zoia CP,Tagliabue E,Isella V,Begni B,Fumagalli L,Brighina L,Appollonio I,Racchi M,Ferrarese C

更新日期：2005-06-01 00:00:00

abstract：:The levels of calpains (m-calpain and mu-calpain) in peripheral blood lymphocytes from patients with Alzheimer's disease were determined via Western blotting. The Ca-dependent proteolytic activity and the calpastatin activity were estimated using incubation with exogenous substrate. Evidence was obtained for an increa...

journal_title：Neurobiology of aging

authors： Karlsson JO,Blennow K,Janson I,Blomgren K,Karlsson I,Regland B,Wallin A,Gottfries CG

更新日期：1995-11-01 00:00:00

abstract：:The observation that neurons containing neurofibrillary tangles are usually adjacent to neurons free of any morphological indication of disease, suggests the hypothesis that it is NFT-bearing neurons that are primarily responsible for the loss of function in AD. Quantitative Golgi postmortem studies from our laborator...

journal_title：Neurobiology of aging

authors： Callahan LM,Coleman PD

更新日期：1995-05-01 00:00:00

abstract：:There is evidence that increased blood concentrations of homocysteine may be a risk factor for Alzheimer's disease. (E)-4-hydroxy-2-nonenal (HNE) is a neurotoxic product of lipid peroxidation that is increased in the ventricular fluid and brains of patients with Alzheimer's disease. We measured the concentrations of h...

journal_title：Neurobiology of aging

authors： Selley ML,Close DR,Stern SE

更新日期：2002-05-01 00:00:00

abstract：:Aging is associated with marked changes in the timing, consolidation and structure of sleep. Older people wake up frequently, get up earlier and have less slow wave sleep than young people, although the extent of these age-related changes differs considerably between individuals. Interindividual differences in homeost...

journal_title：Neurobiology of aging

authors： Viola AU,Chellappa SL,Archer SN,Pugin F,Götz T,Dijk DJ,Cajochen C

更新日期：2012-05-01 00:00:00

abstract：:Age-related differences in opiate receptors were determined using young (1 month old), mature (3 and 8 months old) and aged (20 months old) mice. 3H-Dihydromorphine binding to mu-receptors in brain synaptic membranes consisted of two components: one with high affinity and one with low affinity. High affinity mu bindin...

journal_title：Neurobiology of aging

authors： Ueno E,Liu DD,Ho IK,Hoskins B

更新日期：1988-05-01 00:00:00

abstract：:While cerebrospinal fluid (CSF) biomarkers are of use in the prediction and diagnosis of Alzheimer's disease our understanding of the background effects of age and the ApoE genotype is limited. Seventy-eight community-based normal volunteers (mean age 60+/-10 years, range 36-86) were examined to determine the relation...

journal_title：Neurobiology of aging

authors： Glodzik-Sobanska L,Pirraglia E,Brys M,de Santi S,Mosconi L,Rich KE,Switalski R,Saint Louis L,Sadowski MJ,Martiniuk F,Mehta P,Pratico D,Zinkowski RP,Blennow K,de Leon MJ

更新日期：2009-05-01 00:00:00