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Increased proteolytic activity in lymphocytes from patients with early onset Alzheimer's disease.

Abstract：

:The levels of calpains (m-calpain and mu-calpain) in peripheral blood lymphocytes from patients with Alzheimer's disease were determined via Western blotting. The Ca-dependent proteolytic activity and the calpastatin activity were estimated using incubation with exogenous substrate. Evidence was obtained for an increased Ca-dependent proteolytic activity in lymphocytes from patients with early onset Alzheimer's disease. There was also an increased level of membrane-bound mu-calpain in this group of patients. The observed changes may be caused by a general dysregulation of Ca homeostasis in peripheral cells of early onset Alzheimer victims.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

Karlsson JO,Blennow K,Janson I,Blomgren K,Karlsson I,Regland B,Wallin A,Gottfries CG

doi

10.1016/0197-4580(95)02004-7

subject

Has Abstract

pub_date

1995-11-01 00:00:00

pages

901-6

issue

6

eissn

0197-4580

issn

1558-1497

pii

0197458095020047

journal_volume

16

pub_type

杂志文章

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