Abstract:
:The total number of immunocytochemically identified vasopressin (AVP) cells was determined morphometrically in the paraventricular (PVN) and dorsolateral part of the supraoptic nucleus (dl-SON) of the human hypothalamus in 30 subjects ranging in age from 15 to 97 years, including 10 Alzheimer's disease (AD) patients. The aim of the present study was to test the hypothesis that the increased activity of AVP neurons reported earlier is accompanied by an absence of cell loss in these nuclei in senescence and AD. The results show that numbers of immunoreactive AVP cells in the PVN and dl-SON do not decline during aging or in AD. During aging, the number of neurons expressing AVP even increased in the PVN of control subjects. The nuclear diameter of the AVP cells in the PVN and dl-SON showed an increase in old AD patients. It is concluded that no cell loss occurs in the AVP cell population in the PVN and dl-SON during aging and in AD, and that AVP expression increases in the PVN during normal aging, but not in AD.
journal_name
Neurobiol Agingjournal_title
Neurobiology of agingauthors
Van der Woude PF,Goudsmit E,Wierda M,Purba JS,Hofman MA,Bogte H,Swaab DFdoi
10.1016/0197-4580(95)80003-asubject
Has Abstractpub_date
1995-01-01 00:00:00pages
11-8issue
1eissn
0197-4580issn
1558-1497pii
019745809580003Ajournal_volume
16pub_type
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journal_title:Neurobiology of aging
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