Abstract:
:We examined patterns of cortical thickness loss and cognitive decline over time in 19 patients with Alzheimer's disease (AD), 10 with behavioral variant frontotemporal dementia (bvFTD), and 34 controls with a mean interval of 2.1 ± 0.4 years. We measured vertexwise and regional cortical thickness changes of 6 lobar regions of interest between groups with the longitudinal FreeSurfer pipeline. Compared with controls, AD and bvFTD had a steeper rate of cognitive decline and showed faster cortical thinning per year. Decrease of thickness over time was highest in AD and generalized throughout the whole brain, most pronounced posteriorly, whereas bvFTD patients had a more selective loss in frontal cortex and in anterior parts of the temporal lobes. In a direct comparison, AD patients showed faster cortical thinning in the insula, temporal, and parietal regions, whereas bvFTD patients only showed faster cortical thinning in the orbitofrontal gyrus. Decline of cognitive performances was in line with cortical thinning and deteriorated the most in AD patients.
journal_name
Neurobiol Agingjournal_title
Neurobiology of agingauthors
Möller C,Hafkemeijer A,Pijnenburg YAL,Rombouts SARB,van der Grond J,Dopper E,van Swieten J,Versteeg A,Steenwijk MD,Barkhof F,Scheltens P,Vrenken H,van der Flier WMdoi
10.1016/j.neurobiolaging.2015.10.020subject
Has Abstractpub_date
2016-02-01 00:00:00pages
21-31eissn
0197-4580issn
1558-1497pii
S0197-4580(15)00532-1journal_volume
38pub_type
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