Abstract:
:The performance of male A/J and C57BL/6J mice from three age groups (4, 18, and 24 months) was observed in a battery of tests designed to assess age-related impairments in motor abilities. A/J mice were superior to C57BL/6J mice in tasks requiring upper body strength, such as tests of grip strength and tightrope performance. C57BL/6J mice were superior performers in tasks requiring balance and coordination, such as movement on stationary and rotating rods. In addition, the C57BL/6J strain generally exhibited greater locomotor activity, such as measured in open field and wheel-running tests. Significant age-related deficits were observe among A/J mice in tests of grip strength, balance rod, rotorod, and wheel activity; and among C57BL/6J mice, in balance, rod, tightrope, exploratory activity, and wheel activity tests. Except for scores of exploratory activity (free versus forced exploration), the test measures tended to be uncorrelated; however, the degree and magnitude of intercorrelation among test scores increased with age. The results underscore the need to consider genotype in the assessment of age-related motor impairments in animal models.
journal_name
Neurobiol Agingjournal_title
Neurobiology of agingauthors
Ingram DK,London ED,Reynolds MA,Waller SB,Goodrick CLdoi
10.1016/0197-4580(81)90025-7subject
Has Abstractpub_date
1981-10-01 00:00:00pages
221-7issue
3eissn
0197-4580issn
1558-1497pii
0197-4580(81)90025-7journal_volume
2pub_type
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journal_title:Neurobiology of aging
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journal_title:Neurobiology of aging
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journal_title:Neurobiology of aging
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journal_title:Neurobiology of aging
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journal_title:Neurobiology of aging
pub_type: 杂志文章
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journal_title:Neurobiology of aging
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journal_title:Neurobiology of aging
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journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/0197-4580(94)90075-2
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journal_title:Neurobiology of aging
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journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/0197-4580(94)90150-3
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journal_title:Neurobiology of aging
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journal_title:Neurobiology of aging
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Neurobiology of aging
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journal_title:Neurobiology of aging
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Neurobiology of aging
pub_type: 评论,杂志文章,评审
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