Diffusion tensor and magnetization transfer MRI measurements of periventricular white matter hyperintensities in old age.

Abstract:

:Regions of diffuse periventricular white matter hyperintensities (PVWMH) are a common finding on T(2)-weighted MRI scans of older subjects, but their aetiology remains unclear. The aim of this study was to characterize differences in water diffusion and magnetization transfer MRI parameters between macroscopically normal-appearing white matter (NAWM) and PVWMH in a cohort of normal older subjects. Forty-two non-demented 83-year olds underwent structural, diffusion tensor and magnetization transfer MRI. Mean diffusivity (), fractional anisotropy (FA), axial (lambda(ax)) and radial (lambda(rad)) diffusivity, and magnetization transfer ratio (MTR) were measured in both NAWM and PVWMH in frontal and parieto-occipital white matter, and centrum semiovale. For all three regions, PVWMH had greater , lambda(ax) and lambda(rad) than NAWM, while FA and MTR were significantly reduced compared with normal tissue (p<0.01). For PVWMH, MTR was significantly correlated (Spearman's rho in the range -0.93 to 0.70; p<0.01) with , FA, lambda(ax) and lambda(rad) in all three regions. Conversely, for NAWM, the only significant correlation between MTR and a water diffusion parameter was for lambda(rad) in parieto-occipital white matter (rho=-0.40; p<0.05), with all other correlations close to the rho=0 level. These data indicate that in normal white matter, characterized by structurally coherent cell membranes, the degree of water molecule diffusion and myelination are held within relatively tight limits. However, within PVWMH, MTR correlates strongly with water diffusion parameters probably because of the pathologically associated neuronal loss, demyelination and gliosis.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

Bastin ME,Clayden JD,Pattie A,Gerrish IF,Wardlaw JM,Deary IJ

doi

10.1016/j.neurobiolaging.2007.05.013

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

125-36

issue

1

eissn

0197-4580

issn

1558-1497

pii

S0197-4580(07)00212-6

journal_volume

30

pub_type

杂志文章
  • Agrin and microvascular damage in Alzheimer's disease.

    abstract::Heparan sulfate proteoglycans (HSPGs) are ubiquitously present within the perivascular basement membrane, and have been shown to be altered in patients with Alzheimer's Disease (AD). Although the HSPG agrin clearly orchestrates the differentiation of the neuromuscular junction, its role in the brain remains unclear. G...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/s0197-4580(00)00121-4

    authors: Berzin TM,Zipser BD,Rafii MS,Kuo-Leblanc V,Yancopoulos GD,Glass DJ,Fallon JR,Stopa EG

    更新日期:2000-03-01 00:00:00

  • Age-related subsensitivity of cerebellar Purkinje neurons to locally applied beta 1-selective adrenergic agonist.

    abstract::Previous electrophysiological studies in aged rats have revealed a number of deficits in noradrenergic neurotransmission in the central nervous system. Such deficits include subsensitivity to the depressant effects of norepinephrine on cerebellar Purkinje neurons, which has been attributed specifically to altered beta...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/0197-4580(90)90022-r

    authors: Parfitt KD,Bickford-Wimer P

    更新日期:1990-11-01 00:00:00

  • Neuronal susceptibility to damage: comparison of the retinas of young, old and old/caloric restricted rats before and after transient ischemia.

    abstract::Compared to young rats, old age increases susceptibility and caloric restriction decreases susceptibility for the loss of retinal ganglion cells and displaced amacrine cells following retinal ischemia/reperfusion. In retinas of old animals before ischemia, reactive gliosis, including activation of Muller cells, microg...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/j.neurobiolaging.2003.07.005

    authors: Kim KY,Ju WK,Neufeld AH

    更新日期:2004-04-01 00:00:00

  • Increased proteolytic activity in lymphocytes from patients with early onset Alzheimer's disease.

    abstract::The levels of calpains (m-calpain and mu-calpain) in peripheral blood lymphocytes from patients with Alzheimer's disease were determined via Western blotting. The Ca-dependent proteolytic activity and the calpastatin activity were estimated using incubation with exogenous substrate. Evidence was obtained for an increa...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/0197-4580(95)02004-7

    authors: Karlsson JO,Blennow K,Janson I,Blomgren K,Karlsson I,Regland B,Wallin A,Gottfries CG

    更新日期:1995-11-01 00:00:00

  • Selective white matter pathology induces a specific impairment in spatial working memory.

    abstract::The integrity of the white matter is critical in regulating efficient neuronal communication and maintaining cognitive function. Damage to brain white matter putatively contributes to age-related cognitive decline. There is a growing interest in animal models from which the mechanistic basis of white matter pathology ...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/j.neurobiolaging.2010.09.005

    authors: Coltman R,Spain A,Tsenkina Y,Fowler JH,Smith J,Scullion G,Allerhand M,Scott F,Kalaria RN,Ihara M,Daumas S,Deary IJ,Wood E,McCulloch J,Horsburgh K

    更新日期:2011-12-01 00:00:00

  • Genetic variation in the choline acetyltransferase (CHAT) gene may be associated with the risk of Alzheimer's disease.

    abstract::Several independent linkage studies have mapped a broad susceptibility region for Alzheimer's disease (AD) on the long arm of chromosome 10. There are several biological candidate genes in this region, including choline acetyltransferase (CHAT). A number of studies have examined the role of CHAT genetic variants with ...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/j.neurobiolaging.2005.08.024

    authors: Ozturk A,DeKosky ST,Kamboh MI

    更新日期:2006-10-01 00:00:00

  • Effects of different amyloid β-protein analogues on synaptic function.

    abstract::Perisynaptic accumulations of amyloid β-protein (Aβ) play a critical role in the synaptic dysfunction underlying the cognitive impairment observed in Alzheimer's disease. The methionine residue at position 35 (Met35) in Aβ is highly subject to oxidation in Alzheimer's disease brains. In hippocampal brain slices we fou...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/j.neurobiolaging.2012.06.027

    authors: Ripoli C,Piacentini R,Riccardi E,Leone L,Li Puma DD,Bitan G,Grassi C

    更新日期:2013-04-01 00:00:00

  • Use of tissue culture models to study neuronal regulatory trophic and toxic factors in the aged brain.

    abstract::Dementia is believed to result from the loss of selective neurons within the brain, but approaches for systematic study of that degenerative process are hampered by the complexity of the neuronal milieu. Tissue culture models provide a means to reduce dramatically the variables inherent in the study of neuronal plasti...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章,评审

    doi:10.1016/s0197-4580(88)80142-8

    authors: Azmitia EC,Whitaker-Azmitia PM,Bartus R

    更新日期:1988-09-01 00:00:00

  • DNA end joining activity is reduced in Alzheimer's disease.

    abstract::Evidence indicates that oxidative stress-induced damage to DNA, protein, and other cellular components contributes to the progression of Alzheimer's disease (AD). Several studies indicate that postmitotic neurons have a reduced capacity for some types of DNA repair, which is further compromised by aging. Thus in AD, t...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/j.neurobiolaging.2005.03.009

    authors: Shackelford DA

    更新日期:2006-04-01 00:00:00

  • Subacute ibuprofen treatment rescues the synaptic and cognitive deficits in advanced-aged mice.

    abstract::Aging is accompanied by increased neuroinflammation, synaptic dysfunction, and cognitive deficits both in rodents and humans, yet the onset and progression of these deficits throughout the life span remain unknown. These aging-related deficits affect the quality of life and present challenges to our aging society. Her...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/j.neurobiolaging.2017.02.001

    authors: Rogers JT,Liu CC,Zhao N,Wang J,Putzke T,Yang L,Shinohara M,Fryer JD,Kanekiyo T,Bu G

    更新日期:2017-05-01 00:00:00

  • Place cells of aged rats in two visually identical compartments.

    abstract::Aged rats perform poorly on spatial learning tasks, a cognitive impairment which has been linked to the failure of hippocampal networks to fully encode changes in the external environment [Barnes CA, Suster MS, Shen J, McNaughton BL. Multistability of cognitive maps in the hippocampus of old rats. Nature 1997;388(6639...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/j.neurobiolaging.2004.09.006

    authors: Wilson IA,Ikonen S,Gurevicius K,McMahan RW,Gallagher M,Eichenbaum H,Tanila H

    更新日期:2005-07-01 00:00:00

  • Abeta42, presenilins, and Alzheimer's disease.

    abstract::The significance of amyloid beta protein, especially those ending at the 42nd residue (Abeta42), in the pathogenesis of familial Alzheimer's disease (FAD) linked to the mutations of presenilins, was examined by transfection studies using cultured cells and immunohistochemical analysis of autopsied brains. The levels o...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/s0197-4580(98)00027-x

    authors: Iwatsubo T

    更新日期:1998-01-01 00:00:00

  • Hemodynamic changes during aging associated with cerebral blood flow and impaired cognitive function.

    abstract::This study investigates the age associated changes in hemorheological properties and cerebral blood flow. Partial correlations indicate that part of the age-dependent decrease in flow velocities can be attributed to a hemorheological decrement resulting in part from enhanced oxidative stress in the aged. A possible li...

    journal_title:Neurobiology of aging

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0197-4580(00)00118-4

    authors: Ajmani RS,Metter EJ,Jaykumar R,Ingram DK,Spangler EL,Abugo OO,Rifkind JM

    更新日期:2000-03-01 00:00:00

  • Clinical validity of increased cortical uptake of amyloid ligands on PET as a biomarker for Alzheimer's disease in the context of a structured 5-phase development framework.

    abstract::The use of biomarkers has been proposed for diagnosing Alzheimer's disease in recent criteria, but some biomarkers have not been sufficiently investigated to justify their routine clinical use. Here, we evaluate in a literature review the clinical validity of amyloid positron emission tomography (PET) imaging using a ...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章,评审

    doi:10.1016/j.neurobiolaging.2016.07.012

    authors: Chiotis K,Saint-Aubert L,Boccardi M,Gietl A,Picco A,Varrone A,Garibotto V,Herholz K,Nobili F,Nordberg A,Geneva Task Force for the Roadmap of Alzheimer's Biomarkers.

    更新日期:2017-04-01 00:00:00

  • Cell cycle regulatory failure in neurones: causes and consequences.

    abstract::The number of Alzheimer's disease sufferers shows an alarming increase throughout the world. Therefore elucidation of the pathogenic mechanisms leading to Alzheimer's disease and the design of effective treatment, preventive or curative, became imperative. In the last few years several groups have found evidence indic...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章,评审

    doi:10.1016/s0197-4580(00)00223-2

    authors: Nagy Z

    更新日期:2000-11-01 00:00:00

  • Guanfacine treatment for prefrontal cognitive dysfunction in older participants: a randomized clinical trial.

    abstract::This study evaluated the effect of the alpha-2A-adrenoceptor agonist guanfacine on prefrontally mediated cognitive functions, as well as quality of life and global function in healthy older participants. One hundred twenty-three participants aged 75 years and older were randomly assigned to guanfacine 0.5 mg, 0.1 mg, ...

    journal_title:Neurobiology of aging

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/j.neurobiolaging.2018.05.033

    authors: Barcelos NM,Van Ness PH,Wagner AF,MacAvoy MG,Mecca AP,Anderson GM,Trentalange M,Hawkins KA,Sano M,Arnsten AFT,van Dyck CH

    更新日期:2018-10-01 00:00:00

  • Aging-related changes in brain metabolism are altered by early developmental exposure to diazepam.

    abstract::To study the long-term effects of prenatal diazepam (DZ) exposure, 31P NMR (nuclear magnetic resonance) spectra and levels of thiobarbituric acid (TBA)-reactive material were measured in the brains of rats from 3 to 26 months of age. In control rats, there were aging-related increases in levels of TBA-reactive materia...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/0197-4580(90)90044-z

    authors: Miranda R,Ceckler T,Guillet R,Kellogg CK

    更新日期:1990-03-01 00:00:00

  • Cardiovascular, sympathetic and adrenal cortical responsiveness of aged fischer-344 rats to stress.

    abstract::While resting, Fischer-344 rats underwent a decrease in heart rate and an increase in diastolic blood pressure and plasma norepinephrine with increasing age. The blood pressure of adult rats increased significantly during a 3 minute immobilization. The blood pressure of old rats failed to increase during stress, decre...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/0197-4580(80)90010-x

    authors: Chiueh CC,Nespor SM,Rapoport SI

    更新日期:1980-01-01 00:00:00

  • Vascular risk factors for Alzheimer's disease: an epidemiologic perspective.

    abstract::Vascular disease and Alzheimer's disease are both common disorders, in particular among elderly subjects. Therefore, it can be expected that the joint occurrence of these two disorders is not a rare phenomenon. In recent years, evidence is increasing that the two may be more closely linked than just by chance. Epidemi...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章,评审

    doi:10.1016/s0197-4580(99)00110-4

    authors: Breteler MM

    更新日期:2000-03-01 00:00:00

  • A genome-wide screening and SNPs-to-genes approach to identify novel genetic risk factors associated with frontotemporal dementia.

    abstract::Frontotemporal dementia (FTD) is the second most prevalent form of early onset dementia after Alzheimer's disease (AD). We performed a case-control association study in an Italian FTD cohort (n = 530) followed by the novel single nucleotide polymorphisms (SNPs)-to-genes approach and functional annotation analysis. We ...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/j.neurobiolaging.2015.06.005

    authors: Ferrari R,Grassi M,Salvi E,Borroni B,Palluzzi F,Pepe D,D'Avila F,Padovani A,Archetti S,Rainero I,Rubino E,Pinessi L,Benussi L,Binetti G,Ghidoni R,Galimberti D,Scarpini E,Serpente M,Rossi G,Giaccone G,Tagliavini F

    更新日期:2015-10-01 00:00:00

  • Age-related vulnerability of pattern separation in C57BL/6J mice.

    abstract::Aging is associated with impaired performance in behavioral pattern separation (PS) tasks based on similarities in object features and in object location. These deficits have been attributed to functional alterations in the dentate gyrus (DG)-CA3 region. Animal studies suggested a role of adult-born DG neurons in PS p...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/j.neurobiolaging.2017.10.013

    authors: Cès A,Burg T,Herbeaux K,Héraud C,Bott JB,Mensah-Nyagan AG,Mathis C

    更新日期:2018-02-01 00:00:00

  • Chromosome 9p21.3 genotype is associated with vascular dementia and Alzheimer's disease.

    abstract::Vascular risk factors have been implicated in the pathogenesis of vascular dementia and Alzheimer's disease. The identification of a novel vascular disease susceptibility locus at 9p21.3 has recently generated great interest. In the present study, we sought to determine whether a common genetic variant (tagged by rs13...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/j.neurobiolaging.2009.07.003

    authors: Emanuele E,Lista S,Ghidoni R,Binetti G,Cereda C,Benussi L,Maletta R,Bruni AC,Politi P

    更新日期:2011-07-01 00:00:00

  • Fibroblast glutamate transport in aging and in AD: correlations with disease severity.

    abstract::Altered glutamate transport and aberrant EAAT1 expression were shown in Alzheimer's disease (AD) brains. It is presently unknown whether these modifications are a consequence of neurodegeneration or play a pathogenetic role. However, recent findings of decreased glutamate uptake, EAAT1 protein and mRNA in AD platelets...

    journal_title:Neurobiology of aging

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.neurobiolaging.2004.07.007

    authors: Zoia CP,Tagliabue E,Isella V,Begni B,Fumagalli L,Brighina L,Appollonio I,Racchi M,Ferrarese C

    更新日期:2005-06-01 00:00:00

  • Homozygous TREM2 mutation in a family with atypical frontotemporal dementia.

    abstract::TREM2 mutations were first identified in Nasu-Hakola disease, a rare autosomal recessive disease characterized by recurrent fractures because of bone cysts and presenile dementia. Recently, homozygous and compound heterozygous TREM2 mutations were identified in rare families with frontotemporal lobar degeneration (FTL...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/j.neurobiolaging.2014.04.010

    authors: Le Ber I,De Septenville A,Guerreiro R,Bras J,Camuzat A,Caroppo P,Lattante S,Couarch P,Kabashi E,Bouya-Ahmed K,Dubois B,Brice A

    更新日期:2014-10-01 00:00:00

  • Novel inflammatory markers associated with cognitive performance: Singapore Longitudinal Ageing Studies.

    abstract::We identified and validated several novel inflammatory markers of cognitive performance in community-living older persons. An exploratory study (n = 83) correlated 177 inflammatory markers assayed by Luminex with the Mini-Mental State Examination (MMSE) and identified 8 inflammatory markers for enzyme-linked immunosor...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/j.neurobiolaging.2015.12.002

    authors: Gao Q,Camous X,Lu YX,Lim ML,Larbi A,Ng TP

    更新日期:2016-03-01 00:00:00

  • Sexual behaviors of aging female rats: influence of age and hormonal state of male partners.

    abstract::Proceptive and receptive behaviors were examined in aging and young ovariectomized female rats treated with estradiol benzoate and progesterone. Young females approached males confined in wire mesh cages more frequently and exhibited more proceptive behaviors toward these males than did middle-aged females. Both middl...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/0197-4580(86)90038-2

    authors: Chambers KC,Phoenix CH

    更新日期:1986-05-01 00:00:00

  • Is procedural memory relatively spared from age effects?

    abstract::Numerous types of age-related deficits in the nervous system have been well documented. While a distinction between general types of memories that are susceptible to compromise with advanced age has been fairly well agreed upon, it is often difficult to determine exactly which specific processes are detrimentally infl...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/s0197-4580(02)00194-x

    authors: Churchill JD,Stanis JJ,Press C,Kushelev M,Greenough WT

    更新日期:2003-10-01 00:00:00

  • EEG correlates of visual short-term memory in older age vary with adult lifespan cognitive development.

    abstract::Visual short-term memory (vSTM) is a cognitive resource that declines with age. This study investigated whether electroencephalography (EEG) correlates of vSTM vary with cognitive development over individuals' lifespan. We measured vSTM performance and EEG in a lateralized whole-report task in a healthy birth cohort, ...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/j.neurobiolaging.2017.10.018

    authors: Wiegand I,Lauritzen MJ,Osler M,Mortensen EL,Rostrup E,Rask L,Richard N,Horwitz A,Benedek K,Vangkilde S,Petersen A

    更新日期:2018-02-01 00:00:00

  • Age-related learning and memory deficits in odor-reward association in rats.

    abstract::In these experiments, potential cognitive deficits in aged rats were studied using an odor-reward association task. Aged Fischer 344 rats first performed to an odor-reward association task. After five daily sessions of 60 trials, the aged rats were globally impaired in comparison to the control rats. However, consider...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/0197-4580(95)02030-6

    authors: Roman FS,Alescio-Lautier B,Soumireu-Mourat B

    更新日期:1996-01-01 00:00:00

  • Age-dependent alterations of Kir4.1 expression in neural crest-derived cells of the mouse and human cochlea.

    abstract::Age-related hearing loss (or presbyacusis) is a progressive pathophysiological process. This study addressed the hypothesis that degeneration/dysfunction of multiple nonsensory cell types contributes to presbyacusis by evaluating tissues obtained from young and aged CBA/CaJ mouse ears and human temporal bones. Ultrast...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/j.neurobiolaging.2019.04.009

    authors: Liu T,Li G,Noble KV,Li Y,Barth JL,Schulte BA,Lang H

    更新日期:2019-08-01 00:00:00