Abstract:
:The release of endogenous and newly synthesized acetylcholine (ACh) was examined in neostriatal slices prepared from young adult (10-month) and aged (28-month) Fischer 344 rats. Both spontaneous and potassium-stimulated release were tested after various in vitro incubation times (1, 3 or 5 hr). The potassium-stimulated release of ACh from slices of 28-month rats was decreased by 53% when tested after incubating the slices 1 hr. The age-related differences in ACh release lessened if the slices were incubated for longer times (3 or 5 hr) before monitoring release. The spontaneous release of ACh was similar among the slices from both age-groups and at all times points monitored. When the neostriatal slices were incubated in medium supplemented with deuterated choline, the release of both the endogenous and newly synthesized ACh from slices of 28-month rats was decreased by 33% when tested after a 1-hr incubation, but was again similar to that released from slices of 10-month rats when tested after a 3-hr incubation. Choline release from slices of the 28-month rats was similar to that released from the slices of the 10-month rats when acetylcholinesterase (AChE) was inhibited during the release incubation. In slices with intact AChE activity, however, the age-related difference in choline release was similar to that observed for ACh release when AChE was inhibited. That is, when AChE activity was intact, the potassium-stimulated choline release from slices of 28-month rats was less than that released from slices of 10-month rats when release was tested after a 1-hr incubation.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Neurobiol Agingjournal_title
Neurobiology of agingauthors
Weiler MHdoi
10.1016/0197-4580(90)90006-lsubject
Has Abstractpub_date
1990-07-01 00:00:00pages
401-7issue
4eissn
0197-4580issn
1558-1497pii
0197-4580(90)90006-Ljournal_volume
11pub_type
杂志文章abstract::Recent results support the hypothesis that microglia and/or macrophages of the brain, by producing oxidants, could play a role in the local inactivation of the Kunitz protease inhibitor (KPI) domain of beta-amyloid precursor protein (APP), thereby facilitating deposition of abnormal amyloid filaments in patients with ...
journal_title:Neurobiology of aging
pub_type: 杂志文章
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journal_title:Neurobiology of aging
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更新日期:2017-05-01 00:00:00
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journal_title:Neurobiology of aging
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更新日期:1995-11-01 00:00:00
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journal_title:Neurobiology of aging
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journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/j.neurobiolaging.2015.09.023
更新日期:2016-01-01 00:00:00
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pub_type: 杂志文章
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journal_title:Neurobiology of aging
pub_type: 杂志文章
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journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/0197-4580(92)90017-r
更新日期:1992-01-01 00:00:00
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journal_title:Neurobiology of aging
pub_type: 杂志文章
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journal_title:Neurobiology of aging
pub_type: 评论,杂志文章
doi:10.1016/0197-4580(91)90009-9
更新日期:1991-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2016-03-01 00:00:00
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journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/j.neurobiolaging.2012.12.027
更新日期:2013-07-01 00:00:00
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journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/j.neurobiolaging.2013.10.080
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journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/j.neurobiolaging.2014.03.012
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journal_title:Neurobiology of aging
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journal_title:Neurobiology of aging
pub_type: 杂志文章
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更新日期:2020-11-13 00:00:00
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journal_title:Neurobiology of aging
pub_type: 杂志文章
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journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/j.neurobiolaging.2008.03.007
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journal_title:Neurobiology of aging
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journal_title:Neurobiology of aging
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journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/j.neurobiolaging.2010.05.007
更新日期:2012-03-01 00:00:00
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journal_title:Neurobiology of aging
pub_type: 杂志文章
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更新日期:1989-09-01 00:00:00
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pub_type: 杂志文章
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