当前位置： SCI文献检索 > NEUROBIOLOGY OF AGING期刊下所有文献 > Taste perception of bitter compounds in young and elderly persons: relation to lipophilicity of bitter compounds.

Taste perception of bitter compounds in young and elderly persons: relation to lipophilicity of bitter compounds.

Abstract：

:Threshold and suprathreshold sensitivities to 13 bitter compounds were determined for 16 young adults (mean age = 27.4 years) and 18 elderly persons (mean age = 81.3 years). Half of the subjects in each age group were tasters of the bitter compound phenylthiocarbamide (PTC) and half were nontasters. Both detection and recognition thresholds, determined by a forced-choice ascending detection method, were elevated in older subjects; there were no significant differences in threshold values between tasters and nontasters of PTC. A strong relationship between bitter threshold values and the logarithm of the octanol/water partition coefficient was found for both young and elderly subjects. For young subjects, suprathreshold bitterness ratings were more intense for tasters of PTC compared with nontasters. Significant losses in suprathreshold sensitivity to bitter tastants with age were also found. However, unlike threshold sensitivity, no relationship was found between suprathreshold bitter taste intensity and lipophilicity.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

Schiffman SS,Gatlin LA,Frey AE,Heiman SA,Stagner WC,Cooper DC

doi

10.1016/0197-4580(94)90057-4

subject

Has Abstract

pub_date

1994-11-01 00:00:00

pages

743-50

issue

6

eissn

0197-4580

issn

1558-1497

pii

0197-4580(94)90057-4

journal_volume

15

pub_type

杂志文章

相关文献

NEUROBIOLOGY OF AGING文献大全
  • Chronic circadian disturbance by a shortened light-dark cycle increases mortality.

    abstract：:Chronic circadian disturbance, a condition of desynchronization between endogenous clock and environmental light-dark (LD) cycle, is known to cause adverse physiological changes including mortality. However, it is yet unclear whether these consequences result from disturbance of endogenous clock or condition of the LD...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2011.11.005

    authors： Park N,Cheon S,Son GH,Cho S,Kim K

    更新日期：2012-06-01 00:00:00

  • Increased caveolin-1 expression in Alzheimer's disease brain.

    abstract：:Increasing evidence suggests that cholesterol plays a central role in the pathophysiology of Alzheimer's disease (AD). Caveolin is a cholesterol-binding membrane protein involved in cellular cholesterol transport. We investigated the changes in the protein amount of hippocampal caveolin of autopsy-confirmed AD and age...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2003.07.004

    authors： Gaudreault SB,Dea D,Poirier J

    更新日期：2004-07-01 00:00:00

  • Longitudinal genetic analysis of brain volumes in normal elderly male twins.

    abstract：:This study investigated the role of genetic and environmental influences on individual differences in brain volumes measured at 2 time points in normal elderly males from the National Heart, Lung, and Blood Institute Twin Study. The magnetic resonance imaging (MRI) scans were conducted 4 years apart on 33 monozygotic ...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.neurobiolaging.2010.06.002

    authors： Lessov-Schlaggar CN,Hardin J,DeCarli C,Krasnow RE,Reed T,Wolf PA,Swan GE,Carmelli D

    更新日期：2012-04-01 00:00:00

  • Reduced secretion and altered proteolytic processing caused by missense mutations in progranulin.

    abstract：:Progranulin (GRN) is a secreted growth factor involved in various cellular functions, and loss-of-function mutations are a major cause of frontotemporal lobar degeneration (FTLD) with TDP-43 positive pathology. Most FTLD-related GRN mutations are nonsense mutations resulting in reduced GRN expression. Nonsynonymous GR...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2015.12.014

    authors： Kleinberger G,Capell A,Brouwers N,Fellerer K,Sleegers K,Cruts M,Van Broeckhoven C,Haass C

    更新日期：2016-03-01 00:00:00

  • Parkinsonism is associated with altered primary motor cortex plasticity in frontotemporal dementia-primary progressive aphasia variant.

    abstract：:In frontotemporal dementia (FTD), the behavioral variant (bv-FTD) and nonfluent variant of primary progressive aphasia (nfv-PPA) reflect a prominent neurodegenerative involvement of the frontal lobe networks, which may include the premotor and motor areas and thus cause heterogeneous clinical symptoms including parkin...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2018.05.026

    authors： Di Stasio F,Suppa A,Fabbrini A,Marsili L,Asci F,Conte A,Trebbastoni A,De Lena C,Berardelli A

    更新日期：2018-09-01 00:00:00

  • Regional brain atrophy predicts time to conversion to Alzheimer's disease, dependent on baseline volume.

    abstract：:A key question for the design of clinical trials for Alzheimer's disease (AD) is whether the timing of conversion from mild cognitive impairment (MCI) to AD can be predicted. This is also an important question for the clinical management of MCI. This study aims to address this question by exploring the contribution of...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2019.08.033

    authors： Tabatabaei-Jafari H,Shaw ME,Walsh E,Cherbuin N,Alzheimer's Disease Neuroimaging Initiative (ADNI).

    更新日期：2019-11-01 00:00:00

  • Imaging markers of mild cognitive impairment: multivariate analysis of CBF SPECT.

    abstract：:This study aimed to investigate cross-sectional and longitudinal changes of regional cerebral blood flow (rCBF) in preclinical dementia using single photon emission computed tomography (SPECT). SPECT and cognitive function were investigated in 39 mild cognitive impairment (MCI) subjects and 20 age-matched controls. Al...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2006.05.017

    authors： Huang C,Eidelberg D,Habeck C,Moeller J,Svensson L,Tarabula T,Julin P

    更新日期：2007-07-01 00:00:00

  • Mitochondrial ferritin affects mitochondria by stabilizing HIF-1α in retinal pigment epithelium: implications for the pathophysiology of age-related macular degeneration.

    abstract：:Mitochondrial ferritin (FtMt) is believed to play an antioxidant role via iron regulation, and FtMt gene mutation has been reported in age-related macular degeneration (AMD). However, little is known about FtMt's functions in the retina and any links to AMD. In this study, we observed age-related increase in FtMt and ...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2016.07.025

    authors： Wang X,Yang H,Yanagisawa D,Bellier JP,Morino K,Zhao S,Liu P,Vigers P,Tooyama I

    更新日期：2016-11-01 00:00:00

  • Homozygous alpha-synuclein p.A53V in familial Parkinson's disease.

    abstract：:We have assessed the frequency of alpha-synuclein (SNCA) mutations in Japanese patients with familial or sporadic Parkinson's disease (PD) and surveyed their associated clinical manifestations. We screened SNCA exon 3 in 988 patients without SNCA multiplications (430 with autosomal dominant PD and 558 with sporadic PD...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2017.05.022

    authors： Yoshino H,Hirano M,Stoessl AJ,Imamichi Y,Ikeda A,Li Y,Funayama M,Yamada I,Nakamura Y,Sossi V,Farrer MJ,Nishioka K,Hattori N

    更新日期：2017-09-01 00:00:00

  • Identification of rare genetic variants in Italian patients with dementia by targeted gene sequencing.

    abstract：:Genetics is intricately involved in the etiology of neurodegenerative dementias. The incidence of monogenic dementia among all neurodegenerative forms is unknown due to the lack of systematic studies and of patient/clinician access to extensive diagnostic procedures. In this study, we conducted targeted sequencing in ...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2018.02.006

    authors： Bartoletti-Stella A,Baiardi S,Stanzani-Maserati M,Piras S,Caffarra P,Raggi A,Pantieri R,Baldassari S,Caporali L,Abu-Rumeileh S,Linarello S,Liguori R,Parchi P,Capellari S

    更新日期：2018-06-01 00:00:00

  • Get a grip: individual variations in grip strength are a marker of brain health.

    abstract：:Demonstrations that grip strength has predictive power in relation to a range of health conditions-even when these are assessed decades later-has motivated claims that hand-grip dynamometry has the potential to serve as a "vital sign" for middle-aged and older adults. Central to this belief has been the assumption tha...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章,评审

    doi：10.1016/j.neurobiolaging.2018.07.023

    authors： Carson RG

    更新日期：2018-11-01 00:00:00

  • Spatial navigation training protects the hippocampus against age-related changes during early and late adulthood.

    abstract：:It is unknown whether lifestyle, including mental stimulation, and appropriate training interventions, may directly improve spatial navigation performance and its underlying neural substrates. Here we report that healthy younger and older men performing a cognitively demanding spatial navigation task every other day o...

    journal_title：Neurobiology of aging

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.neurobiolaging.2011.02.013

    authors： Lövdén M,Schaefer S,Noack H,Bodammer NC,Kühn S,Heinze HJ,Düzel E,Bäckman L,Lindenberger U

    更新日期：2012-03-01 00:00:00

  • Antioxidant-enriched diet does not delay the progression of age-related hearing loss.

    abstract：:Oxidative stress has been linked to noise- and drug-induced as well as age-related hearing loss. Antioxidants can attenuate the decline of cochlear structure and function after exposure to noise or drugs, but it is debated as to whether they can protect from age-related hearing loss. In a long-term longitudinal study,...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2011.10.023

    authors： Sha SH,Kanicki A,Halsey K,Wearne KA,Schacht J

    更新日期：2012-05-01 00:00:00

  • Guanfacine treatment for prefrontal cognitive dysfunction in older participants: a randomized clinical trial.

    abstract：:This study evaluated the effect of the alpha-2A-adrenoceptor agonist guanfacine on prefrontally mediated cognitive functions, as well as quality of life and global function in healthy older participants. One hundred twenty-three participants aged 75 years and older were randomly assigned to guanfacine 0.5 mg, 0.1 mg, ...

    journal_title：Neurobiology of aging

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.neurobiolaging.2018.05.033

    authors： Barcelos NM,Van Ness PH,Wagner AF,MacAvoy MG,Mecca AP,Anderson GM,Trentalange M,Hawkins KA,Sano M,Arnsten AFT,van Dyck CH

    更新日期：2018-10-01 00:00:00

  • No association of Tachykinin receptor 2 (TACR2) polymorphisms with Alzheimer's disease.

    abstract：:The Tachykinin Receptor 2 (TACR2) located at chromosome 10q21.3 belongs to a class of receptors that bind members of the tachykinin neurotransmitter family. The TACR2 binds neurokinin A, also known as substance K, and is expressed in distinct parts of the human brain. Functionally, the TACR2 has been implicated in str...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2009.03.007

    authors： Friedrich P,Feulner TM,Laws SM,Eckart K,Perneczky R,Kurz A,Förstl H,Riemenschneider M

    更新日期：2011-03-01 00:00:00

  • Sympathetic neuroaxonal dystrophy in the aged rat pineal gland.

    abstract：:Dysfunction of circadian melatonin production by the pineal gland in aged humans and rats is thought to reflect the functional loss of its sympathetic innervation. Our ultrastructural neuropathologic studies of the sympathetic innervation of the pineal gland of aged (24 months old) Fischer-344 and Sprague-Dawley rats ...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2005.08.005

    authors： Schmidt RE,Dorsey DA,Parvin CA,Beaudet LN

    更新日期：2006-10-01 00:00:00

  • Beyond measurement: the pattern is the thing.

    abstract：:Perhaps cognitive and brain imaging measures have been pushed almost as far as they can go in helping diagnose or understand AD. Their value may increase with the development of better models of the disease and the addition of new types of measurements to the armamentarium (e.g., eye-tracking, olfactory, and dermatogl...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/s0197-4580(88)80033-2

    authors： Roberts E

    更新日期：1988-01-01 00:00:00

  • Distinctive age-related temporal cortical thinning in asymptomatic granulin gene mutation carriers.

    abstract：:Studies in asymptomatic granulin gene (GRN) mutation carriers are essential to improve our understanding of the pattern and timing of early morphologic brain changes in frontotemporal lobar degeneration. The main objectives of this study were to assess the effect of age in cortical thickness changes (CTh) in preclinic...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2012.11.005

    authors： Moreno F,Sala-Llonch R,Barandiaran M,Sánchez-Valle R,Estanga A,Bartrés-Faz D,Sistiaga A,Alzualde A,Fernández E,Martí Massó JF,López de Munain A,Indakoetxea B

    更新日期：2013-05-01 00:00:00

  • Alzheimer disease pathology in cognitively healthy elderly: a genome-wide study.

    abstract：:Many elderly individuals remain dementia-free throughout their life. However, some of these individuals exhibit Alzheimer disease neuropathology on autopsy, evidenced by neurofibrillary tangles (NFTs) in AD-specific brain regions. We conducted a genome-wide association study to identify genetic mechanisms that disting...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2010.01.010

    authors： Kramer PL,Xu H,Woltjer RL,Westaway SK,Clark D,Erten-Lyons D,Kaye JA,Welsh-Bohmer KA,Troncoso JC,Markesbery WR,Petersen RC,Turner RS,Kukull WA,Bennett DA,Galasko D,Morris JC,Ott J

    更新日期：2011-12-01 00:00:00

  • Late-life hemoglobin and the incidence of Parkinson's disease.

    abstract：:Brain iron promotes neurodegeneration in Parkinson's disease (PD). While hemoglobin (Hb) is the most abundant source of peripheral iron in humans, its relationship with PD is uncertain. This report examines the association between Hb in late life and PD incidence. From 1991 to 1993, Hb was measured in 3507 men in the ...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2010.06.023

    authors： Abbott RD,Ross GW,Tanner CM,Andersen JK,Masaki KH,Rodriguez BL,White LR,Petrovitch H

    更新日期：2012-05-01 00:00:00

  • Differential effects of amyloid-beta 1-40 and 1-42 fibrils on 5-HT1A serotonin receptors in rat brain.

    abstract：:Evidence accumulates suggesting a complex interplay between neurodegenerative processes and serotonergic neurotransmission. We have previously reported an overexpression of serotonin 5-HT1A receptors (5-HT(1A)R) after intrahippocampal injections of amyloid-beta 1-40 (Aβ40) fibrils in rats. This serotonergic reactivity...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2015.12.008

    authors： Verdurand M,Chauveau F,Daoust A,Morel AL,Bonnefoi F,Liger F,Bérod A,Zimmer L

    更新日期：2016-04-01 00:00:00

  • Death by color: differential cone loss in the aging mouse retina.

    abstract：:Differential cell death is a common feature of aging and age-related disease. In the retina, 30% of rod photoreceptors are lost over life in humans and rodents. However, studies have failed to show age-related cell death in mouse cone photoreceptors, which is surprising because cone physiological function declines wit...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2014.05.012

    authors： Cunea A,Powner MB,Jeffery G

    更新日期：2014-11-01 00:00:00

  • Acute treatment with the PDE4 inhibitor roflumilast improves verbal word memory in healthy old individuals: a double-blind placebo-controlled study.

    abstract：:There is ample evidence that phosphodiesterase 4 (PDE4) inhibition can improve memory performance in animal studies. In the present study, we examined the acute effects of the PDE4 inhibitor roflumilast on memory performance in healthy individuals (60-80 years of age). We tested the effects of acute roflumilast admini...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.neurobiolaging.2019.01.014

    authors： Blokland A,Van Duinen MA,Sambeth A,Heckman PRA,Tsai M,Lahu G,Uz T,Prickaerts J

    更新日期：2019-05-01 00:00:00

  • Anomalies occurring in lipid profiles and protein distribution in frontal cortex lipid rafts in dementia with Lewy bodies disclose neurochemical traits partially shared by Alzheimer's and Parkinson's diseases.

    abstract：:Lipid rafts are highly dynamic membrane microdomains intimately associated with cell signaling. Compelling evidence has demonstrated that alterations in lipid rafts are associated with neurodegenerative diseases such Alzheimer's disease, but at present, whether alterations in lipid raft microdomains occur in other typ...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2016.08.027

    authors： Marin R,Fabelo N,Martín V,Garcia-Esparcia P,Ferrer I,Quinto-Alemany D,Díaz M

    更新日期：2017-01-01 00:00:00

  • New evidences for fractalkine/CX3CL1 involved in substantia nigral microglial activation and behavioral changes in a rat model of Parkinson's disease.

    abstract：:Activated microglia are instrumental to neurodegeneration in Parkinson's disease (PD). Fractalkine, as an exclusive ligand for CX3CR1 expressed on microglia, has recently been reported to be released out by neurons, and induce microglial activation as a neuron-to-glia signal in the spinal cord. However, the role of fr...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2009.03.004

    authors： Shan S,Hong-Min T,Yi F,Jun-Peng G,Yue F,Yan-Hong T,Yun-Ke Y,Wen-Wei L,Xiang-Yu W,Jun M,Guo-Hua W,Ya-Ling H,Hua-Wei L,Ding-Fang C

    更新日期：2011-03-01 00:00:00

  • Age-related retinal inflammation is reduced by 670 nm light via increased mitochondrial membrane potential.

    abstract：:The mitochondrial theory of aging argues that oxidative stress, caused by mitochondrial DNA mutations, is associated with decreased adenosine triphosphate (ATP) production leading to cellular degeneration. The rate of this degradation is linked to metabolic demand, with the outer retina having the greatest in the body...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2012.04.014

    authors： Kokkinopoulos I,Colman A,Hogg C,Heckenlively J,Jeffery G

    更新日期：2013-02-01 00:00:00

  • LRRK2 and Parkin mutations in a family with parkinsonism-Lack of genotype-phenotype correlation.

    abstract：:Here we report the relationship between age at onset, clinical course and genotype in a family with combined LRRK2 G2019S and Parkin exon 2 deletions. In the combined mutation carriers the age at onset and clinical course was highly variable and not always younger than in the carriers of LRRK2 G2019S mutations alone. ...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2008.05.030

    authors： Marras C,Klein C,Lang AE,Wakutani Y,Moreno D,Sato C,Yip E,Munhoz RP,Lohmann K,Djarmati A,Bi A,Rogaeva E

    更新日期：2010-04-01 00:00:00

  • Protection of injured retinal ganglion cell dendrites and unfolded protein response resolution after long-term dietary resveratrol.

    abstract：:Long-term dietary supplementation with resveratrol protects against cardiovascular disease, osteoporesis, and metabolic decline. This study determined how long-term dietary resveratrol treatment protects against retinal ganglion cell (RGC) dendrite loss after optic nerve injury and alters the resolution of the unfolde...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2014.12.021

    authors： Lindsey JD,Duong-Polk KX,Hammond D,Leung CK,Weinreb RN

    更新日期：2015-05-01 00:00:00

  • Classical conditioning: the Rosetta stone for brain substrates of age-related deficits in learning and memory.

    abstract：:The three chapters on the use of classical conditioning paradigms to investigate neurobiological and behavioral substrates of memory impairments with aging are in close agreement on all key issues. Based on these chapters, it is argued here that classical conditioning of discrete behavioral responses in rabbit and oth...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/s0197-4580(88)80111-8

    authors： Thompson RF

    更新日期：1988-09-01 00:00:00

  • Profiling of endogenous brain peptides and small proteins: methodology, computer-assisted analysis, and application to aging and lesion models.

    abstract：:Significant advances in the technology for the isolation of peptides and small proteins have permitted their identification as biologic markers and enhanced the study of the posttranslational life of proteins. The protocol described here examined large numbers of tissue-derived peptides and small proteins, extracted i...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/0197-4580(92)90087-e

    authors： Slemmon JR,Flood DG

    更新日期：1992-11-01 00:00:00