Sympathetic neuroaxonal dystrophy in the aged rat pineal gland.

abstract：:Behavioral profiles of young (3-6 months) and aged (24-27 months) rats were compared in three respects: (1) short-term memory, (2) exploration and (3) locomotor activity. Compared to young rats, aged rats were impaired in the 8-arm radial maze acquisition, but not in the delayed reinforced alternation acquisition. The...

journal_title：Neurobiology of aging

authors： Willig F,Palacios A,Monmaur P,M'Harzi M,Laurent J,Delacour J

更新日期：1987-09-01 00:00:00

abstract：:Loss-of-function caused by mutations in the parkin gene (PARK2) lead to early-onset familial Parkinson's disease. Recently, mechanistic studies proved the ability of parkin in regulating mitochondria homeostasis and microtubule (MT) stability. Looking at these systems during aging of PARK2 knockout mice, we found that...

journal_title：Neurobiology of aging

authors： Cartelli D,Amadeo A,Calogero AM,Casagrande FVM,De Gregorio C,Gioria M,Kuzumaki N,Costa I,Sassone J,Ciammola A,Hattori N,Okano H,Goldwurm S,Roybon L,Pezzoli G,Cappelletti G

更新日期：2018-01-01 00:00:00

abstract：:Recently, a mutation in NUS1 has been reported to be associated with Parkinson's disease (PD) in a Chinese population. To further investigate the relationship between NUS1 and sporadic PD, we sequenced all exons and exon-intron boundaries of NUS1 in Chinese Han population including 494 PD patients and 478 healthy cont...

journal_title：Neurobiology of aging

authors： Chen X,Xiao Y,Zhou M,Lin Y,Guo W,Huang S,Qiu J,Peng G,Mo M,Li Z,Zhu X,Xu P

更新日期：2020-02-01 00:00:00

abstract：:In an autopsy series of 19 individuals, age-ranged 24-94, a relatively age-spared region, the anterior-ventral thalamus, was analyzed by immunohistochemical techniques to visualize neurons (neurofilament protein), astrocytes (glial fibrillary acidic protein), microglial cells (CD68) and amyloid precursor protein. The ...

journal_title：Neurobiology of aging

authors： Guidolin D,Zunarelli E,Genedani S,Trentini GP,De Gaetani C,Fuxe K,Benegiamo C,Agnati LF

更新日期：2008-06-01 00:00:00

abstract：:Older adults have altered perception of the relative timing between auditory and visual stimuli, even when stimuli are scaled to equate detectability. To help understand why, this study investigated the neural correlates of audiovisual synchrony judgments in older adults using electroencephalography (EEG). Fourteen yo...

journal_title：Neurobiology of aging

authors： Chan YM,Pianta MJ,Bode S,McKendrick AM

更新日期：2017-07-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a lethal neurological disease primarily involving the spinal cord, brainstem, and corticospinal tract. Recently, mutations in the GLE1 gene were reported in Caucasian ALS patients. To inquire whether Chinese ALS patients carried causal mutations in the gene, we screened all 16 co...

journal_title：Neurobiology of aging

authors： Zhang K,Liu Q,Shen D,Tai H,Fu H,Liu S,Chen J,Li X,Liu M,Zhang X,Cui L

更新日期：2018-06-01 00:00:00

abstract：:While cerebrospinal fluid (CSF) biomarkers are of use in the prediction and diagnosis of Alzheimer's disease our understanding of the background effects of age and the ApoE genotype is limited. Seventy-eight community-based normal volunteers (mean age 60+/-10 years, range 36-86) were examined to determine the relation...

journal_title：Neurobiology of aging

authors： Glodzik-Sobanska L,Pirraglia E,Brys M,de Santi S,Mosconi L,Rich KE,Switalski R,Saint Louis L,Sadowski MJ,Martiniuk F,Mehta P,Pratico D,Zinkowski RP,Blennow K,de Leon MJ

更新日期：2009-05-01 00:00:00

abstract：:Subcortical structural changes have been reported to occur in some elderly subjects with late age onset depression. Given the association between diseases affecting subcortical structures and affective disorders, this suggests that these structural changes may be involved in the etiology of late age onset depression i...

journal_title：Neurobiology of aging

authors： Figiel GS,Krishnan KR,Doraiswamy PM,Rao VP,Nemeroff CB,Boyko OB

更新日期：1991-05-01 00:00:00

abstract：:The supraoptic nucleus of the F344 rat shows an age-related dendritic regression. In order to determine whether this previously observed dendritic regression may have been related to extrinsic (to the cell) hormonal, neurotoxic, or other circulating factors unique to the hypothalamus of older brains, we conducted a qu...

journal_title：Neurobiology of aging

authors： Kaplan AS,Gash DM,Flood DG,Coleman PD

更新日期：1985-10-01 00:00:00

abstract：:Age related alterations in mnemonic ability and in the functional status of muscarinic receptors were evaluated and compared to biochemical measures of pre and post-synaptic cholinergic functioning. Retention of a single trial passive avoidance task was considerably disturbed as a function of aging. The functional sta...

journal_title：Neurobiology of aging

authors： Lippa AS,Pelham RW,Beer B,Critchett DJ,Dean RL,Bartus RT

更新日期：1980-07-01 00:00:00

abstract：:The activities of presenilin 1 (PS1) and 2 modulate the proteolytic processing of amyloid precursor proteins to produce Abeta1-42, and mutations in these proteins are associated with an accelerated rate of Abeta deposition. PS1 and PS2 themselves are subject to a highly-regulated endoproteolytic cleavage to generate s...

journal_title：Neurobiology of aging

authors： Borchelt DR,Lee MK,Gonzales V,Slunt HH,Ratovitski T,Jenkins NA,Copeland NG,Price DL,Sisodia SS

更新日期：2002-03-01 00:00:00

abstract：:Homozygous mutations of the glucocerebrosidase gene (GBA) cause Gaucher disease (GD), and heterozygous mutations of GBA are a major risk factor for Parkinson's disease (PD). This study examined the impact of GBA mutations on the longitudinal clinical course of PD patients by retrospective cohort design. GBA-coding reg...

journal_title：Neurobiology of aging

authors： Oeda T,Umemura A,Mori Y,Tomita S,Kohsaka M,Park K,Inoue K,Fujimura H,Hasegawa H,Sugiyama H,Sawada H

更新日期：2015-12-01 00:00:00

abstract：:In terminal Alzheimer's disease (AD) the frequency of plaques was found to be reduced in single cases. To test this finding in a larger sample, and in order to determine whether the number of plaques labeled with different markers and the distribution of neurofibrillary tangles are correlated positively to each other ...

journal_title：Neurobiology of aging

authors： Thal DR,Arendt T,Waldmann G,Holzer M,Zedlick D,Rüb U,Schober R

更新日期：1998-11-01 00:00:00

abstract：:One major pathological process in Alzheimer's disease is mediated by hyperphosphorylated tau, which includes altered microtubules (MTs) and functions associated with tau. A potential way to compensate for altered MT function is to use an MT stabilizer, such as epothilone D (EpoD). Previous studies have demonstrated im...

journal_title：Neurobiology of aging

authors： Guo B,Huang Y,Gao Q,Zhou Q

更新日期：2020-12-01 00:00:00

abstract：:Mutations in triggering receptor expressed on myeloid cells 2 (TREM2), which has been proposed to regulate the inflammatory responses and the clearance of apoptotic neurons and/or amyloid-β, are genetically linked to increased risk for late-onset Alzheimer's disease (AD). Interestingly, a missense variant in TREM-like...

journal_title：Neurobiology of aging

authors： Zheng H,Liu CC,Atagi Y,Chen XF,Jia L,Yang L,He W,Zhang X,Kang SS,Rosenberry TL,Fryer JD,Zhang YW,Xu H,Bu G

更新日期：2016-06-01 00:00:00

abstract：:We investigated whether a 2-month dietary supplementation of antioxidants, in the form of blueberry phytochemicals, could reverse or retard the age-related decline in temporal processing speed observed in the aged rat. To this end, extracellular single unit responses to frequency modulated (FM) sweeps were recorded in...

journal_title：Neurobiology of aging

authors： de Rivera C,Shukitt-Hale B,Joseph JA,Mendelson JR

更新日期：2006-07-01 00:00:00

abstract：:The mechanism by which amyloid beta (Aβ) causes neuronal dysfunction and/or death in Alzheimer's disease (AD) is unclear. Previously, we showed that Aβ inhibits several microtubule-dependent kinesin motors essential for mitosis and also present in mature neurons. Here, we show that inhibition of kinesin 5 (Eg5) by Aβ ...

journal_title：Neurobiology of aging

authors： Ari C,Borysov SI,Wu J,Padmanabhan J,Potter H

更新日期：2014-08-01 00:00:00

abstract：:Neuroimage measures from magnetic resonance (MR) imaging, such as cortical thickness, have been playing an increasingly important role in searching for biomarkers of Alzheimer's disease (AD). Recent studies show that, AD, mild cognitive impairment (MCI) and normal control (NC) can be distinguished with relatively high...

journal_title：Neurobiology of aging

authors： Li Y,Wang Y,Wu G,Shi F,Zhou L,Lin W,Shen D,Alzheimer's Disease Neuroimaging Initiative.

更新日期：2012-02-01 00:00:00

abstract：:Appreciation of the role that inflammatory mediators play in Alzheimer's disease (AD) pathogenesis continues to be hampered by two related misconceptions. The first is that to be pathogenically significant a neurodegenerative mechanism must be primary. The second is that inflammation merely occurs to clear the detriti...

journal_title：Neurobiology of aging

authors： Rogers J,Webster S,Lue LF,Brachova L,Civin WH,Emmerling M,Shivers B,Walker D,McGeer P

更新日期：1996-09-01 00:00:00

abstract：:This study examined the progression of sleep-disordered breathing (SDB) over 1 year in two samples of elderly subjects: 45 healthy controls (20 men; 25 women mean age 74.8 years) and 27 recently spousally bereaved elders (9 men; 18 women, mean age 69.7 years). Although controls and bereaved subjects did not differ in ...

journal_title：Neurobiology of aging

authors： Hoch CC,Reynolds CF 3rd,Buysse DJ,Machen M,Schlernitzauer M,Hall F,Kupfer DJ

更新日期：1992-11-01 00:00:00

abstract：:Oxidative stress is believed to be a significant cause of Parkinson's disease (PD). DJ-1 is thought to be an oxidative sensor that protects cells from oxidative insult. It was reported that the level of total DJ-1 protein was significantly reduced in the substantia nigra of sporadic PD patients, suggesting that abnorm...

journal_title：Neurobiology of aging

authors： Xiong R,Wang Z,Zhao Z,Li H,Chen W,Zhang B,Wang L,Wu L,Li W,Ding J,Chen S

更新日期：2014-03-01 00:00:00

abstract：:Paranodal axo-glial junctional complexes anchor the myelin sheath to the axon and breakdown of these complexes presumably facilitates demyelination. Myelin deterioration is also prominent in the aging central nervous system (CNS); however, the stability of the paranodal complexes in the aged CNS has not been examined....

journal_title：Neurobiology of aging

authors： Shepherd MN,Pomicter AD,Velazco CS,Henderson SC,Dupree JL

更新日期：2012-01-01 00:00:00

abstract：:The performance of male A/J and C57BL/6J mice from three age groups (4, 18, and 24 months) was observed in a battery of tests designed to assess age-related impairments in motor abilities. A/J mice were superior to C57BL/6J mice in tasks requiring upper body strength, such as tests of grip strength and tightrope perfo...

journal_title：Neurobiology of aging

authors： Ingram DK,London ED,Reynolds MA,Waller SB,Goodrick CL

更新日期：1981-10-01 00:00:00

abstract：:Aging is associated with alterations in different systems that govern neuronal calcium homeostasis. This study was designed to determine whether any of these alterations may contribute to the decline in spatial working memory that is observed in old rats. Several parameters [initial (5 s) and steady state (15 min) 45C...

journal_title：Neurobiology of aging

authors： Huidobro A,Blanco P,Villalba M,Gómez-Puertas P,Villa A,Pereira R,Bogónez E,Martínez-Serrano A,Aparicio JJ,Satrústegui J

更新日期：1993-09-01 00:00:00

abstract：:Aging of the nervous system is characterized by reduced anatomical plasticity. The cause of this decreased plasticity is not known because it is usually not possible to distinguish between extrinsic and intrinsic factors that affect neuronal growth. One example of age-related reduced neuronal plasticity that is amenda...

journal_title：Neurobiology of aging

authors： Crutcher KA

更新日期：1990-05-01 00:00:00

abstract：:While aging is generally associated with episodic memory decline, not all older adults exhibit memory loss. Furthermore, emotional memories are not subject to the same extent of forgetting and appear preserved in aging. We conducted high-resolution fMRI during a task involving pattern separation of emotional informati...

journal_title：Neurobiology of aging

authors： Leal SL,Noche JA,Murray EA,Yassa MA

更新日期：2017-01-01 00:00:00

abstract：:In the present study, we aim at investigating whether education modulates dynamical properties of time-varying whole-brain network connectivity (the chronnectome) in frontotemporal dementia (FTD) at a given level of symptom severity. Dynamic connectivity parameters were evaluated in 128 patients with FTD using indepen...

journal_title：Neurobiology of aging

authors： Premi E,Cristillo V,Gazzina S,Benussi A,Alberici A,Cotelli MS,Calhoun VD,Iraji A,Magoni M,Cotelli M,Micheli A,Gasparotti R,Padovani A,Borroni B

更新日期：2020-09-01 00:00:00

abstract：:Abnormal neuronal excitability and impaired synaptic plasticity might occur before the degeneration and death of neurons in Alzheimer's disease (AD). To elucidate potential biophysical alterations underlying aberrant neuronal network activity in AD, we performed whole-cell patch clamp analyses of L-type (nifedipine-se...

journal_title：Neurobiology of aging

authors： Wang Y,Mattson MP

更新日期：2014-01-01 00:00:00

abstract：:The perimenopausal transition at middle age is often associated with hot flashes and sleep disruptions, metabolic changes, and other symptoms. Whereas the mechanisms for these processes are incompletely understood, both aging (AG) and a loss of ovarian estrogens play contributing roles. Furthermore, the timing of when...

journal_title：Neurobiology of aging

authors： Yin W,Borniger JC,Wang X,Maguire SM,Munselle ML,Bezner KS,Tesfamariam HM,Garcia AN,Hofmann HA,Nelson RJ,Gore AC

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Aging is a major risk factor for a variety of neurobiological diseases leading to variations of transcriptional expression in affected tissues. Reverse transcription of RNA followed by quantitative PCR is a powerful technique for detection and quantification of specific transcripts differentially expressed. ...

journal_title：Neurobiology of aging

authors： Sieber MW,Guenther M,Kohl M,Witte OW,Claus RA,Frahm C

更新日期：2010-04-01 00:00:00