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Population-based analysis of cholesteryl ester transfer protein identifies association between I405V and cognitive decline: the Cache County Study.

Abstract：

:Cholesterol has been implicated in the pathogenesis of late-onset Alzheimer's disease (LOAD) and the cholesteryl ester transfer protein (CETP) is critical to cholesterol regulation within the cell, making CETP an Alzheimer's disease candidate gene. Several studies have suggested that CETP I405V (rs5882) is associated with cognitive function and LOAD risk, but findings vary and most studies have been conducted using relatively small numbers of samples. To test whether this variant is involved in cognitive function and LOAD progression, we genotyped 4486 subjects with up to 12 years of longitudinal cognitive assessment. Analyses revealed an average 0.6-point decrease per year in the rate of cognitive decline for each additional valine (p < 0.011). We failed to detect the association between CETP I405V and LOAD status (p < 0.28). We conclude that CETP I405V is associated with preserved cognition over time but is not associated with LOAD status.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

Lythgoe C,Perkes A,Peterson M,Schmutz C,Leary M,Ebbert MT,Ridge PG,Norton MC,Tschanz JT,Munger RG,Corcoran CD,Kauwe JS

doi

10.1016/j.neurobiolaging.2014.08.022

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

547.e1-3

issue

1

eissn

0197-4580

issn

1558-1497

pii

S0197-4580(14)00535-1

journal_volume

36

pub_type

杂志文章

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