Age-related changes in regulator of G-protein signaling (RGS)-10 expression in peripheral and central immune cells may influence the risk for age-related degeneration.


:Inflammation in the aging brain increases risk for neurodegenerative disease. In humans, the regulator of G-protein signaling-10 (RGS10) locus has been associated with age-related maculopathy. Chronic peripheral administration of lipopolysaccharide in the RGS10-null mice induces nigral dopaminergic (DA) degeneration, suggesting that RGS10 modulates neuroimmune interactions and may influence susceptibility to neurodegeneration. Because age is the strongest risk factor for neurodegenerative disease, we assessed whether RGS10 expression changes with age and whether aged RGS10-null mice have altered immune cell profiles. Loss of RGS10 in aged mice does not alter the regulation of nigral DA neurons but does alter B-cell, monocyte, microglial, and CD4+ T-cell populations and inflammatory cytokine levels in the cerebrospinal fluid. These results suggest that loss of RGS10 is associated with an age-dependent dysregulation of peripheral and central immune cells rather than dysregulation of DA neuron function.


Neurobiol Aging


Neurobiology of aging


Kannarkat GT,Lee JK,Ramsey CP,Chung J,Chang J,Porter I,Oliver D,Shepherd K,Tansey MG




Has Abstract


2015-05-01 00:00:00














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    pub_type: 临床试验,杂志文章,随机对照试验


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    authors: Chapman TR,Barrientos RM,Ahrendsen JT,Hoover JM,Maier SF,Patterson SL

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    journal_title:Neurobiology of aging

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    authors: Labad J,Price JF,Strachan MW,Deary IJ,Seckl JR,Sattar N,Reynolds RM,Edinburgh Type 2 Diabetes Study Investigators.

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    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Hughes TM,Lopez OL,Evans RW,Kamboh MI,Williamson JD,Klunk WE,Mathis CA,Price JC,Cohen AD,Snitz BE,Dekosky ST,Kuller LH

    更新日期:2014-04-01 00:00:00

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    journal_title:Neurobiology of aging

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    authors: Carro E,Trejo JL,Gerber A,Loetscher H,Torrado J,Metzger F,Torres-Aleman I

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    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Pettigrew C,Soldan A,Zhu Y,Cai Q,Wang MC,Moghekar A,Miller MI,Singh B,Martinez O,Fletcher E,DeCarli C,Albert M

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    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Muller M,Appelman AP,van der Graaf Y,Vincken KL,Mali WP,Geerlings MI

    更新日期:2011-05-01 00:00:00

  • Aging and long-term ovariectomy alter the cytoarchitecture of the hypothalamic-preoptic area of the C57BL/6J mouse.

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    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Miller MM,Gould BE,Nelson JF

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    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Kalinderi K,Fidani L,Katsarou Z,Clarimón J,Bostantjopoulou S,Kotsis A

    更新日期:2011-03-01 00:00:00

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    journal_title:Neurobiology of aging

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    authors: Benedict C,Jacobsson JA,Rönnemaa E,Sällman-Almén M,Brooks S,Schultes B,Fredriksson R,Lannfelt L,Kilander L,Schiöth HB

    更新日期:2011-06-01 00:00:00