Abstract：
:Inflammation in the aging brain increases risk for neurodegenerative disease. In humans, the regulator of G-protein signaling-10 (RGS10) locus has been associated with age-related maculopathy. Chronic peripheral administration of lipopolysaccharide in the RGS10-null mice induces nigral dopaminergic (DA) degeneration, suggesting that RGS10 modulates neuroimmune interactions and may influence susceptibility to neurodegeneration. Because age is the strongest risk factor for neurodegenerative disease, we assessed whether RGS10 expression changes with age and whether aged RGS10-null mice have altered immune cell profiles. Loss of RGS10 in aged mice does not alter the regulation of nigral DA neurons but does alter B-cell, monocyte, microglial, and CD4+ T-cell populations and inflammatory cytokine levels in the cerebrospinal fluid. These results suggest that loss of RGS10 is associated with an age-dependent dysregulation of peripheral and central immune cells rather than dysregulation of DA neuron function.
journal_name
Neurobiol Agingjournal_title
Neurobiology of agingauthors
Kannarkat GT,Lee JK,Ramsey CP,Chung J,Chang J,Porter I,Oliver D,Shepherd K,Tansey MGdoi
10.1016/j.neurobiolaging.2015.02.006subject
Has Abstractpub_date
2015-05-01 00:00:00pages
1982-93issue
5eissn
0197-4580issn
1558-1497pii
S0197-4580(15)00106-2journal_volume
36pub_type
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