Age-related changes in regulator of G-protein signaling (RGS)-10 expression in peripheral and central immune cells may influence the risk for age-related degeneration.

Abstract:

:Inflammation in the aging brain increases risk for neurodegenerative disease. In humans, the regulator of G-protein signaling-10 (RGS10) locus has been associated with age-related maculopathy. Chronic peripheral administration of lipopolysaccharide in the RGS10-null mice induces nigral dopaminergic (DA) degeneration, suggesting that RGS10 modulates neuroimmune interactions and may influence susceptibility to neurodegeneration. Because age is the strongest risk factor for neurodegenerative disease, we assessed whether RGS10 expression changes with age and whether aged RGS10-null mice have altered immune cell profiles. Loss of RGS10 in aged mice does not alter the regulation of nigral DA neurons but does alter B-cell, monocyte, microglial, and CD4+ T-cell populations and inflammatory cytokine levels in the cerebrospinal fluid. These results suggest that loss of RGS10 is associated with an age-dependent dysregulation of peripheral and central immune cells rather than dysregulation of DA neuron function.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

Kannarkat GT,Lee JK,Ramsey CP,Chung J,Chang J,Porter I,Oliver D,Shepherd K,Tansey MG

doi

10.1016/j.neurobiolaging.2015.02.006

subject

Has Abstract

pub_date

2015-05-01 00:00:00

pages

1982-93

issue

5

eissn

0197-4580

issn

1558-1497

pii

S0197-4580(15)00106-2

journal_volume

36

pub_type

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