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Widespread distribution of tauopathy in preclinical Alzheimer's disease.

Abstract：

:The objective of this study was to examine the distribution and severity of tau-PET binding in cognitively normal adults with preclinical Alzheimer's disease as determined by positive beta-amyloid PET. 18F-AV-1451 tau-PET data from 109 cognitively normal older adults were processed with 34 cortical and 9 subcortical FreeSurfer regions and averaged across both hemispheres. Individuals were classified as being beta-amyloid positive (N = 25, A+) or negative (N = 84, A-) based on a 18F-AV-45 beta-amyloid-PET standardized uptake value ratio of 1.22. We compared the tau-PET binding in the 2 groups using covariate-adjusted linear regressions. The A+ cohort had higher tau-PET binding within 8 regions: precuneus, amygdala, banks of the superior temporal sulcus, entorhinal cortex, fusiform gyrus, inferior parietal cortex, inferior temporal cortex, and middle temporal cortex. These findings, consistent with preclinical involvement of the medial temporal lobe and parietal lobe and association regions by tauopathy, emphasize that therapies targeting tauopathy in Alzheimer's disease could be considered before the onset of symptoms to prevent or ameliorate cognitive decline.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

Schultz SA,Gordon BA,Mishra S,Su Y,Perrin RJ,Cairns NJ,Morris JC,Ances BM,Benzinger TLS

doi

10.1016/j.neurobiolaging.2018.08.022

subject

Has Abstract

pub_date

2018-12-01 00:00:00

pages

177-185

eissn

0197-4580

issn

1558-1497

pii

S0197-4580(18)30313-0

journal_volume

72

pub_type

杂志文章

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