Abstract:
:We present a fresh approach to evaluating association with candidate genes and cognitive change by testing association for parameters describing individual growth curves from twins. Moderate genetic influences on memory in aging adults has been shown in quantitative genetic studies. A recently reported, association of a HTR2A polymorphism with episodic memory in young unrelated adults led us to investigate the association between a nearby polymorphism and longitudinal memory performance in the Swedish Adoption/Twin Study of Aging (SATSA). Analysis of growth curve parameters suggests that both how well individuals perform on figural memory at age 65 years and nonlinear change in figural memory performance across age are associated with HTR2A. Individuals with two copies of the common G allele demonstrated higher figural memory performance longitudinally than those with the less frequent A allele, with performance trajectories differing by 2-6% per year. These findings imply a role for the 5-HT2A serotonin receptor on the formation of episodic memories in older adults.
journal_name
Neurobiol Agingjournal_title
Neurobiology of agingauthors
Reynolds CA,Jansson M,Gatz M,Pedersen NLdoi
10.1016/j.neurobiolaging.2004.12.009subject
Has Abstractpub_date
2006-01-01 00:00:00pages
150-4issue
1eissn
0197-4580issn
1558-1497pii
S0197-4580(05)00045-Xjournal_volume
27pub_type
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