Abstract：
:Reduced excitability, due to an increase in the slow afterhyperpolarization (and its underlying current sI(AHP)), occurs in CA1 pyramidal cells in aged cognitively-impaired, but not cognitively-unimpaired, rodents. We sought to determine whether similar age-related changes in the sI(AHP) occur in pyramidal cells in the rhesus monkey dorsolateral prefrontal cortex (dlPFC). Whole-cell patch-clamp recordings were obtained from layer 3 and layer 5 pyramidal cells in dlPFC slices prepared from young (9.6 ± 0.7 years old) and aged (22.3 ± 0.7 years old) behaviorally characterized subjects. The amplitude of the sI(AHP) was significantly greater in layer 3 (but not layer 5) cells from aged-impaired compared with both aged-unimpaired and young monkeys, which did not differ. Aged layer 3, but not layer 5, cells exhibited significantly increased action potential firing rates, but there was no relationship between sI(AHP) and firing rate. Thus, in monkey dlPFC layer 3 cells, an increase in sI(AHP) is associated with age-related cognitive decline; however, this increase is not associated with a reduction in excitability.
journal_name
Neurobiol Agingjournal_title
Neurobiology of agingauthors
Luebke JI,Amatrudo JMdoi
10.1016/j.neurobiolaging.2010.07.002subject
Has Abstractpub_date
2012-06-01 00:00:00pages
1085-95issue
6eissn
0197-4580issn
1558-1497pii
S0197-4580(10)00309-Xjournal_volume
33pub_type
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pub_type： 杂志文章,多中心研究
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