Tau positron emission tomography using [18F]THK5351 and cerebral glucose hypometabolism in Alzheimer's disease.

abstract：:Data are emerging that the altered development of adrenocortical and emotional reactivity in individuals exposed perinatally to adverse events is reflected in cognitive change and that maternal care is an important determinant. However, early trauma does not cause a generalized cognitive decline at older age, but rath...

journal_title：Neurobiology of aging

authors： de Kloet ER,Oitzl MS

更新日期：2003-05-01 00:00:00

abstract：:Lipsitz and Goldberger proposed that there is a loss in the complexity of physiological and behavioral systems with aging and disease. Here, we show that this unidirectional view of the change in system complexity is too narrow in its consideration of the actual changes that occur with aging and disease. An increase o...

journal_title：Neurobiology of aging

authors： Vaillancourt DE,Newell KM

更新日期：2002-01-01 00:00:00

abstract：:Accumulating evidence indicates that white matter degeneration contributes to the neural disconnections that underlie Alzheimer's disease pathophysiology. Although this white matter degeneration is partly attributable to axonopathy associated with neuronal degeneration, amyloid β (Aβ) protein-mediated damage to oligod...

journal_title：Neurobiology of aging

authors： Horiuchi M,Maezawa I,Itoh A,Wakayama K,Jin LW,Itoh T,Decarli C

更新日期：2012-03-01 00:00:00

abstract：:The triple transgenic mouse model (3×TgAD: APPswe, TauP301L, PS1M146V) recapitulates both amyloid β (Aβ)- and tau-related lesions as well as synaptic and memory deficits. In these mice, we reported an early apathy-like behavior and alterations in synaptic plasticity appearing concomitantly with intraneuronal accumulat...

journal_title：Neurobiology of aging

authors： Bourgeois A,Lauritzen I,Lorivel T,Bauer C,Checler F,Pardossi-Piquard R

更新日期：2018-11-01 00:00:00

abstract：:Variants in exon 4 of gene encoding GLT8D1 (glycosyltransferase 8 domain containing 1) gene have recently been suggested as a novel cause of amyotrophic lateral sclerosis (ALS). In addition, there is a synergism between GLT8D1 and ARPP21 (cAMP Regulated Phosphoprotein 21) variants for ALS. However, this observation ha...

journal_title：Neurobiology of aging

authors： Li W,Liu Z,Sun W,Yuan Y,Hu Y,Ni J,Jiao B,Fang L,Li J,Shen L,Tang B,Wang J

更新日期：2020-01-01 00:00:00

abstract：:Etiologically heterogeneous subgroups of patients with Alzheimer's disease (AD) exist and need to be distinguished so as to better identify genetic causes of familial cases. Furthermore, the presence of AD neuropathology in Down syndrome (trisomy 21) subjects older than 35 years suggests that AD in some cases is cause...

journal_title：Neurobiology of aging

authors： Schapiro MB,Rapoport SI

更新日期：1989-09-01 00:00:00

abstract：:In a prospective study of dementia in Flanders (Belgium), we observed a substantial fraction of early-onset dementia patients who did not fulfill the criteria for a specific dementia subtype, leaving the patients without a precise clinical diagnosis. We selected 211 of these patients for genetic testing of causal gene...

journal_title：Neurobiology of aging

authors： Perrone F,Cacace R,Van Mossevelde S,Van den Bossche T,De Deyn PP,Cras P,Engelborghs S,van der Zee J,Van Broeckhoven C

更新日期：2018-09-01 00:00:00

abstract：:Age-related macular degeneration (AMD) has been linked to memory deficits, with no established neural mechanisms. We collected resting-state brain functional magnetic resonance imaging and standardized verbal recall tests from 42 older adults with AMD and 41 age-matched controls. We used seed-based whole brain analysi...

journal_title：Neurobiology of aging

authors： Zuo X,Zhuang J,Chen NK,Cousins S,Cunha P,Lad EM,Madden DJ,Potter G,Whitson HE

更新日期：2020-11-01 00:00:00

abstract：:We sought to describe change in cardiorespiratory (CR) fitness over 2 years in those with early-stage Alzheimer's disease (AD) and nondemented aging and assess the relationship of CR fitness with cognitive decline, brain atrophy, and dementia progression. Individuals with early-stage AD (n = 37) and without dementia (...

journal_title：Neurobiology of aging

authors： Vidoni ED,Honea RA,Billinger SA,Swerdlow RH,Burns JM

更新日期：2012-08-01 00:00:00

abstract：:Vergence eye movements were recorded with the scleral search-coil system in 32 healthy subjects (ages 19-73 years) to characterize the age-related effects on the dynamic parameters of vergence responses to step (transient components) and ramp or sinusoidal targets (sustained components) under natural viewing condition...

journal_title：Neurobiology of aging

authors： Rambold H,Neumann G,Sander T,Helmchen C

更新日期：2006-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is a uniquely human brain disorder characterized by the accumulation of amyloid-beta protein (Aβ) into extracellular plaques, neurofibrillary tangles (NFT) made from intracellular, abnormally phosphorylated tau, and selective neuronal loss. We analyzed a large group of aged chimpanzees (n = 20...

journal_title：Neurobiology of aging

authors： Edler MK,Sherwood CC,Meindl RS,Hopkins WD,Ely JJ,Erwin JM,Mufson EJ,Hof PR,Raghanti MA

更新日期：2017-11-01 00:00:00

abstract：:Alterations in the buffering capacity of the proteostasis network are a salient feature of Alzheimer's disease, associated with the occurrence of chronic endoplasmic reticulum (ER) stress. To cope with ER stress, cells activate the unfolded protein response (UPR), a signal transduction pathway that enforces adaptive p...

journal_title：Neurobiology of aging

authors： Gerakis Y,Hetz C

更新日期：2018-03-01 00:00:00

abstract：:It is well established that mitochondrial fragmentation plays a key role in the pathogenesis of Alzheimer's disease (AD). Mitochondrial fission is mediated by dynamin-related protein 1 (Drp1), which is highly expressed in nervous system and regulated by various posttranslational modifications including phosphorylation...

journal_title：Neurobiology of aging

authors： Yan J,Liu XH,Han MZ,Wang YM,Sun XL,Yu N,Li T,Su B,Chen ZY

更新日期：2015-01-01 00:00:00

abstract：:Age-related decline in microstructural integrity of certain white matter tracts may explain cognitive decline associated with normal aging. Whole brain tractography and a clustering segmentation in 48 healthy individuals across the adult lifespan were used to examine: interhemispheric (corpus callosum), intrahemispher...

journal_title：Neurobiology of aging

authors： Voineskos AN,Rajji TK,Lobaugh NJ,Miranda D,Shenton ME,Kennedy JL,Pollock BG,Mulsant BH

更新日期：2012-01-01 00:00:00

abstract：:Glycogen synthase kinase-3β (GSK3B) and cyclin-dependent kinase 5 (CDK5) are the 2 major protein kinases involved in abnormal phosphorylation of tau. To determine their potential role in the pathogenesis of Parkinson's disease (PD) we analyzed 2 functional single nucleotide polymorphisms (SNPs) of GSK3B (rs334558 and ...

journal_title：Neurobiology of aging

authors： Das G,Misra AK,Das SK,Ray K,Ray J

更新日期：2012-07-01 00:00:00

abstract：:To investigate possible age-associated changes in human synaptic connectivity, superior-middle frontal cortex (Brodmann area 9) was evaluated with ultrastructural techniques. Short post mortem autopsy tissue was obtained from 37 cognitive normal individuals ranging in age from 20 to 89 years. A minimum of five subject...

journal_title：Neurobiology of aging

authors： Scheff SW,Price DA,Sparks DL

更新日期：2001-05-01 00:00:00

abstract：:Visual function declines with age. This deterioration results not only from changes in the optical system but also from the functional degradation of the central visual cortex. Although numerous studies have explored the mechanisms of age-related influences on vision, they have failed to acknowledge the significance o...

journal_title：Neurobiology of aging

authors： Wang X,Zhang B,Wang H,Liu J,Xu G,Zhou Y

更新日期：2019-04-01 00:00:00

abstract：:Decreased levels of cerebrospinal fluid (CSF) Abeta42 is a diagnostic marker of Alzheimer's disease. To clarify the biological basis of this marker, the physiological alterations of CSF Abeta40 and Abeta42 by aging were studied. CSF samples from 92 normal subjects between 8 and 89 years old were measured using a speci...

journal_title：Neurobiology of aging

authors： Shoji M,Kanai M,Matsubara E,Tomidokoro Y,Shizuka M,Ikeda Y,Ikeda M,Harigaya Y,Okamoto K,Hirai S

更新日期：2001-03-01 00:00:00

abstract：:We studied the hippocampal angle and spatial relationships of medial temporal lobe (MTL) structures, using midbrain colliculi and inter-collicular sulcus (ICS) as landmarks, and measured MTL width on axial 3D-T1-weighted MRI at ICS level in 41 normal, aged participants. Mean hippocampal angle was 29 degrees (range 17-...

journal_title：Neurobiology of aging

authors： Gao FQ,Black SE,Leibovitch FS,Callen DJ,Lobaugh NJ,Szalai JP

更新日期：2003-01-01 00:00:00

abstract：:Healthy aged adult (24-26 months of age) and young adult (2-4 months of age) c57BL/6J male mice were assessed for intermale aggression, pup-killing behavior (infanticide), and circulating levels of testosterone (T). When compared to young adult male mice, aged adult males were highly variable in the exhibition of both...

journal_title：Neurobiology of aging

authors： Svare B,Mann M,Broida J,Kinsley C,Ghiraldi L,Miele J,Konen C

更新日期：1983-01-01 00:00:00

abstract：:Results from basic and clinical studies demonstrate that stress and depression decrease neurotrophic factor expression and neurogenesis in brain, and that antidepressant treatment blocks or reverses these effects, leading to a neurotrophic hypothesis of depression. Neurotrophic factor expression and neurogenesis are a...

journal_title：Neurobiology of aging

authors： Duman RS

更新日期：2005-12-01 00:00:00

abstract：:There is developing interest in the potential association between anesthesia and the onset and progression of Alzheimer's disease. Several anesthetics have, thus, been demonstrated to induce tau hyperphosphorylation, an effect mostly mediated by anesthesia-induced hypothermia. Here, we tested the hypothesis that acute...

journal_title：Neurobiology of aging

authors： Whittington RA,Virág L,Gratuze M,Petry FR,Noël A,Poitras I,Truchetti G,Marcouiller F,Papon MA,El Khoury N,Wong K,Bretteville A,Morin F,Planel E

更新日期：2015-08-01 00:00:00

abstract：:We investigated both independent and interconnected effects of 3 lifestyle factors on brain volume, measuring yearly changes using large-scale longitudinal magnetic resonance imaging, in middle-aged to older adults. We measured brain volumes in a cohort (n = 984, 49-79 years) from the Korean Genome and Epidemiology St...

journal_title：Neurobiology of aging

authors： Kim RE,Yun CH,Thomas RJ,Oh JH,Johnson HJ,Kim S,Lee S,Seo HS,Shin C

更新日期：2018-09-01 00:00:00

abstract：:Age-related changes in the interactive behavior of default mode network (DMN) with other resting state networks are poorly understood. We hypothesized that age would positively correlate with inter-network connectivity in late life and intellectual functioning was expected to moderate this relationship. The sample con...

journal_title：Neurobiology of aging

authors： Lindbergh CA,Zhao Y,Lv J,Mewborn CM,Puente AN,Terry DP,Renzi-Hammond LM,Hammond BR,Liu T,Miller LS

更新日期：2019-06-01 00:00:00

abstract：:Delivery of drugs to specific sites in the CNS represents an essential therapeutic challenge. Extradural administration of opiates successfully delivers drugs to the CNS. The levodopa-carbidopa combination achieved some degree of site-specific delivery by pharmacological methods. Antibiotics have been administered thr...

journal_title：Neurobiology of aging

authors： Hollister LE

更新日期：1989-09-01 00:00:00

abstract：:Since diabetes is a risk factor for Alzheimer's disease (AD), we asked if there is a functional interaction between high glucose and elevated beta amyloid peptide (Abeta) in cultured brain microvascular endothelial cells and presymptomatic AD transgenic mice. When cultured brain microvascular endothelial cells are exp...

journal_title：Neurobiology of aging

authors： Burdo JR,Chen Q,Calcutt NA,Schubert D

更新日期：2009-12-01 00:00:00

abstract：:Mimicking relevant behavioral features of the human pathology is one of the most important challenges for animal models of neurological disorders including Alzheimer disease (AD). Indeed, the most popular genetic AD mouse lines bearing mutations of the amyloid precursor protein (APP) and presenilin 1 genes (PS1), ofte...

journal_title：Neurobiology of aging

authors： Pietropaolo S,Delage P,Lebreton F,Crusio WE,Cho YH

更新日期：2012-05-01 00:00:00

abstract：:Aging-related episodic memory decline is often attributed to insufficient encoding of new information, although the underlying neural processes remain elusive. We here tested the hypothesis that impaired memory consolidation contributes to aging-related memory decline. To this end, we used resting state functional mag...

journal_title：Neurobiology of aging

authors： Kukolja J,Göreci DY,Onur ÖA,Riedl V,Fink GR

更新日期：2016-09-01 00:00:00

abstract：:To study the long-term effects of prenatal diazepam (DZ) exposure, 31P NMR (nuclear magnetic resonance) spectra and levels of thiobarbituric acid (TBA)-reactive material were measured in the brains of rats from 3 to 26 months of age. In control rats, there were aging-related increases in levels of TBA-reactive materia...

journal_title：Neurobiology of aging

authors： Miranda R,Ceckler T,Guillet R,Kellogg CK

更新日期：1990-03-01 00:00:00

abstract：:Progranulin (GRN) is a secreted growth factor involved in various cellular functions, and loss-of-function mutations are a major cause of frontotemporal lobar degeneration (FTLD) with TDP-43 positive pathology. Most FTLD-related GRN mutations are nonsense mutations resulting in reduced GRN expression. Nonsynonymous GR...

journal_title：Neurobiology of aging

authors： Kleinberger G,Capell A,Brouwers N,Fellerer K,Sleegers K,Cruts M,Van Broeckhoven C,Haass C

更新日期：2016-03-01 00:00:00