Abstract：
:The effects of age were studied on a new animal model of tardive dyskinesia, i.e., the quantification of oral dyskinesia in rats repeatedly treated with reserpine. Adult and old rats received two injections of reserpine (0.5 or 1.0 mg/kg s.c.) or vehicle, separated by 48 h. One, 10, 25 and 40 days after the second injection of reserpine or vehicle, the animals were observed for quantification of the behavioral parameters of oral dyskinesia: tongue protrusion and vacuous chewing movement frequencies and duration of twitching of the facial musculature. Phenomenologically, control old rats and reserpine-treated adult animals showed very similar oral dyskinesia. When compared to control adult rats, the significant increase in tongue protrusion frequency induced by reserpine treatment was more persistent in the old rats than in the adult animals. Because it is well known that age increases the persistence of tardive dyskinesia, our data provide further support for the validation of reserpine-induced oral dyskinesia as an animal model of tardive dyskinesia. In addition, the possibility is raised that a common pathophysiological mechanism may underlie tardive dyskinesia and age- and reserpine-induced oral dyskinesia.
journal_name
Neurobiol Agingjournal_title
Neurobiology of agingauthors
Bergamo M,Abílio VC,Queiroz CM,Barbosa-Júnior HN,Abdanur LR,Frussa-Filho Rdoi
10.1016/s0197-4580(97)00152-8subject
Has Abstractpub_date
1997-11-01 00:00:00pages
623-9issue
6eissn
0197-4580issn
1558-1497pii
S0197458097001528journal_volume
18pub_type
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pub_type： 杂志文章
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