Mapping ventricular expansion onto cortical gray matter in older adults.

abstract：:Stroke is an important risk factor for dementia, but the exact mechanisms involved in cognitive decline remain unclear. In this study, we related baseline MRI brain measures with later cognitive decline. Seventy-nine stroke survivors aged 75+ years without dementia were recruited 3-month post-stroke. They underwent ye...

journal_title：Neurobiology of aging

authors： Firbank MJ,Burton EJ,Barber R,Stephens S,Kenny RA,Ballard C,Kalaria RN,O'Brien JT

更新日期：2007-11-01 00:00:00

abstract：:To determine if the membrane disordering effect of ethanol on cerebral microvessels is altered with age, the steady state fluorescence polarization (P) of diphenyl-hexatriene (DPH) and 1-(4-trimethylammoniumphenyl)-6-phenyl-1,3,5-hexatriene (TMA-DPH) which report on the membrane core and surface region, respectively, ...

journal_title：Neurobiology of aging

authors： Mooradian AD,Smith TL

更新日期：1993-05-01 00:00:00

abstract：:Parkinson's disease (PD) is a progressive neurodegenerative disease with typical motor symptoms due to the preferential loss of midbrain dopaminergic (mDA) neurons in the Substantia nigra pars compacta. Several proteins of the homeodomain family are crucial for the development of mDA neurons. These proteins remain exp...

journal_title：Neurobiology of aging

authors： Fuchs J,Mueller JC,Lichtner P,Schulte C,Munz M,Berg D,Wüllner U,Illig T,Sharma M,Gasser T

更新日期：2009-05-01 00:00:00

abstract：:The substantia innominata (SI) contains the nucleus basalis of Meynert, which provides the major cholinergic innervation to the entire cortical mantel and the amygdala; degeneration of nucleus basalis neurons correlates with cognitive decline in Alzheimer's disease (AD). However, whether SI atrophy occurs in individua...

journal_title：Neurobiology of aging

authors： George S,Mufson EJ,Leurgans S,Shah RC,Ferrari C,deToledo-Morrell L

更新日期：2011-10-01 00:00:00

abstract：:Mutations in the presenilin genes account for the majority of familial Alzheimer disease (FAD) cases. In the present report we demonstrated that the FAD-linked presenilin 2 mutations (PS2 M239I and T122R) alter cystatin C trafficking in mouse primary neurons reducing secretion of its glycosylated form. These mutations...

journal_title：Neurobiology of aging

authors： Ghidoni R,Benussi L,Paterlini A,Missale C,Usardi A,Rossi R,Barbiero L,Spano P,Binetti G

更新日期：2007-03-01 00:00:00

abstract：:Age-related differences in opiate receptors were determined using young (1 month old), mature (3 and 8 months old) and aged (20 months old) mice. 3H-Dihydromorphine binding to mu-receptors in brain synaptic membranes consisted of two components: one with high affinity and one with low affinity. High affinity mu bindin...

journal_title：Neurobiology of aging

authors： Ueno E,Liu DD,Ho IK,Hoskins B

更新日期：1988-05-01 00:00:00

abstract：:In an autopsy series of 19 individuals, age-ranged 24-94, a relatively age-spared region, the anterior-ventral thalamus, was analyzed by immunohistochemical techniques to visualize neurons (neurofilament protein), astrocytes (glial fibrillary acidic protein), microglial cells (CD68) and amyloid precursor protein. The ...

journal_title：Neurobiology of aging

authors： Guidolin D,Zunarelli E,Genedani S,Trentini GP,De Gaetani C,Fuxe K,Benegiamo C,Agnati LF

更新日期：2008-06-01 00:00:00

abstract：:The abnormal proliferation and neurogenesis of neural progenitor cells (NPCs) is usually associated with the pathophysiology of neurodegenerative disorders such as Alzheimer's disease (AD). Mitochondrial stress is one of the most prominent features of AD and is thought to be involved in the impairment of the neurogene...

journal_title：Neurobiology of aging

authors： Huang S,Cao X,Zhou Y,Shi F,Xin S,He S,An Y,Gao L,Yang Y,Yu B,Pei G

更新日期：2019-08-01 00:00:00

abstract：:It is unknown whether lifestyle, including mental stimulation, and appropriate training interventions, may directly improve spatial navigation performance and its underlying neural substrates. Here we report that healthy younger and older men performing a cognitively demanding spatial navigation task every other day o...

journal_title：Neurobiology of aging

authors： Lövdén M,Schaefer S,Noack H,Bodammer NC,Kühn S,Heinze HJ,Düzel E,Bäckman L,Lindenberger U

更新日期：2012-03-01 00:00:00

abstract：:Omegaconotoxin binding was studied in young (3 months) and old (24 months) male Sprague-Dawley rats. In both groups omegaconotoxin binding displayed high affinity, was specific and saturable. The age-related changes are mainly a decrease in the Bmax in striatum and cortex (-29% and -31%, respectively). Binding paramet...

journal_title：Neurobiology of aging

authors： Moresco RM,Govoni S,Battaini F,Trivulzio S,Trabucchi M

更新日期：1990-07-01 00:00:00

abstract：:Type 2 diabetes mellitus is a risk factor of Alzheimer's disease (AD), most likely linked to an impairment of insulin signaling in the brain. Liraglutide, a novel long-lasting glucagon-like peptide 1 (GLP-1) analog, facilitates insulin signaling and shows neuroprotective properties. In the present study, we analyzed t...

journal_title：Neurobiology of aging

authors： Han WN,Hölscher C,Yuan L,Yang W,Wang XH,Wu MN,Qi JS

更新日期：2013-02-01 00:00:00

abstract：:Aging has been related to diminished cognitive function, which could be a result of ineffective synaptic function. We have previously shown that synaptic plasma membrane proteins supporting synaptic integrity and neurotransmission were downregulated in docosahexaenoic acid (DHA)-deprived brains, suggesting an importan...

journal_title：Neurobiology of aging

authors： Sidhu VK,Huang BX,Desai A,Kevala K,Kim HY

更新日期：2016-05-01 00:00:00

abstract：:Age-related decline in microstructural integrity of certain white matter tracts may explain cognitive decline associated with normal aging. Whole brain tractography and a clustering segmentation in 48 healthy individuals across the adult lifespan were used to examine: interhemispheric (corpus callosum), intrahemispher...

journal_title：Neurobiology of aging

authors： Voineskos AN,Rajji TK,Lobaugh NJ,Miranda D,Shenton ME,Kennedy JL,Pollock BG,Mulsant BH

更新日期：2012-01-01 00:00:00

abstract：:Age-related changes in the interactive behavior of default mode network (DMN) with other resting state networks are poorly understood. We hypothesized that age would positively correlate with inter-network connectivity in late life and intellectual functioning was expected to moderate this relationship. The sample con...

journal_title：Neurobiology of aging

authors： Lindbergh CA,Zhao Y,Lv J,Mewborn CM,Puente AN,Terry DP,Renzi-Hammond LM,Hammond BR,Liu T,Miller LS

更新日期：2019-06-01 00:00:00

abstract：:The neurobiology of aging continues to attract scientists and techniques from the more fundamental disciplines, as witness the great strides now being made from molecular genetic approaches to Alzheimer's disease. The present report is a commentary on reviews of immune mechanisms and tissue culture methods applied to ...

journal_title：Neurobiology of aging

authors： Rogers J,Rovigatti U

更新日期：1988-09-01 00:00:00

abstract：:Individuals with Down syndrome (DS), caused by trisomy of chromosome 21, inevitably develop characteristic Alzheimer's disease (AD) neuropathology, including neuritic plaques, neurofibrillary tangles, and neuronal loss. Amyloid-β protein, the major component of neuritic plaques, is the proteolytic product of amyloid-β...

journal_title：Neurobiology of aging

authors： Wu Y,Deng Y,Zhang S,Luo Y,Cai F,Zhang Z,Zhou W,Li T,Song W

更新日期：2015-01-01 00:00:00

abstract：:The associations of 4 proteins-AK4, ITPK1, HSPB2, and IGFBP5-with cognitive function in older adults were largely unexplained by known brain pathologies. We examined the extent to which individual protein associations with cognitive decline were attributable to microstructural changes in the brain. This study included...

journal_title：Neurobiology of aging

authors： Kim N,Yu L,Dawe R,Petyuk VA,Gaiteri C,De Jager PL,Schneider JA,Arfanakis K,Bennett DA

更新日期：2019-12-01 00:00:00

abstract：:Reduced excitability, due to an increase in the slow afterhyperpolarization (and its underlying current sI(AHP)), occurs in CA1 pyramidal cells in aged cognitively-impaired, but not cognitively-unimpaired, rodents. We sought to determine whether similar age-related changes in the sI(AHP) occur in pyramidal cells in th...

journal_title：Neurobiology of aging

authors： Luebke JI,Amatrudo JM

更新日期：2012-06-01 00:00:00

abstract：:Previous electrophysiological studies in aged rats have revealed a number of deficits in noradrenergic neurotransmission in the central nervous system. Such deficits include subsensitivity to the depressant effects of norepinephrine on cerebellar Purkinje neurons, which has been attributed specifically to altered beta...

journal_title：Neurobiology of aging

authors： Parfitt KD,Bickford-Wimer P

更新日期：1990-11-01 00:00:00

abstract：:Age-related cognitive decline is a major public health concern facing a large segment of the US population. To identify genetic risk factors related to cognitive decline, we used nationally representative longitudinal data from the US Health and Retirement Study to conduct genome-wide association studies with 5765 par...

journal_title：Neurobiology of aging

authors： Zhang C,Pierce BL

更新日期：2014-06-01 00:00:00

abstract：:Insomnia, daytime sleepiness, and nocturnal wandering, so common in the elderly, are caused largely by two specific pathophysiologic processes. Sleep apnea is a condition where respiration pauses during sleep, leading to arousal. Sleep apnea is due either to obstruction in the throat or failure of the central respirat...

journal_title：Neurobiology of aging

authors： Kripke DF,Ancoli-Israel S,Okudaira N

更新日期：1982-01-01 00:00:00

abstract：:Aged rats were chronically administered acetyl-L-carnitine (AC) for 10 months. During this period they were tested on learning and sensorimotor tasks and were then subsequently tested electrophysiologically to assess induction and decay rates of long-term synaptic enhancement (LTE) in the hippocampus. Four groups were...

journal_title：Neurobiology of aging

authors： Davis S,Markowska AL,Wenk GL,Barnes CA

更新日期：1993-01-01 00:00:00

abstract：:During aging, lifestyle-related factors shape the brain's response to insults and modulate the progression of neurodegenerative pathologies such as Alzheimer's disease (AD). This is the case for chronic hyperglycemia associated with type 2 diabetes, which reduces the brain's ability to handle the neurodegenerative bur...

journal_title：Neurobiology of aging

authors： Ferreiro E,Lanzillo M,Canhoto D,Carvalho da Silva AM,Mota SI,Dias IS,Ferreira IL,Fontes AR,Mastrella G,Pinheiro P,Valero J,Rego AC

更新日期：2020-08-01 00:00:00

abstract：:Alzheimer's disease (AD) has been suggested to be a systemic disease, and signal transduction abnormalities have been reported in non-neuronal AD cells. We have previously quantified the protein kinase C (PKC) subtypes in AD and control brains using a two-site enzyme immunoassay (EIA), and have shown that type II PKC ...

journal_title：Neurobiology of aging

authors： Matsushima H,Shimohama S,Tanaka S,Taniguchi T,Hagiwara M,Hidaka H,Kimura J

更新日期：1994-11-01 00:00:00

abstract：:I propose that North American investigators who depend largely on individual external grants would benefit from the creation of regional facilities designed to support studies of aging in transgenic models. In general, academic institutions cannot achieve the most cost effectiveness because their facilities are not de...

journal_title：Neurobiology of aging

authors： Finch CE

更新日期：1999-03-01 00:00:00

abstract：:Aging is associated with marked changes in the timing, consolidation and structure of sleep. Older people wake up frequently, get up earlier and have less slow wave sleep than young people, although the extent of these age-related changes differs considerably between individuals. Interindividual differences in homeost...

journal_title：Neurobiology of aging

authors： Viola AU,Chellappa SL,Archer SN,Pugin F,Götz T,Dijk DJ,Cajochen C

更新日期：2012-05-01 00:00:00

abstract：:Progranulin (GRN) gene mutations have been genetically associated with frontotemporal dementia (FTD) and are present in about 23% of patients with familial FTD. However, the neurobiology of this secreted glycoprotein remains unclear. Here, we report the identification of 3 pedigrees of Southern Italian extraction in w...

journal_title：Neurobiology of aging

authors： Milan G,Napoletano S,Pappatà S,Gentile MT,Colucci-D'Amato L,Della Rocca G,Maciag A,Rossetti CP,Fucci L,Puca A,Grossi D,Postiglione A,Vitale E

更新日期：2017-05-01 00:00:00

abstract：:Linkage data in Alzheimer's disease have not firmly established a genetic locus on chromosome 21 in early onset disease families. There is little or no support for a chromosome 21 locus in late onset families. Differences in the selection of families and the analysis of data accounts for the differences in interpretat...

journal_title：Neurobiology of aging

authors： Roses AD

更新日期：1989-09-01 00:00:00

abstract：:Time-dependent changes in brain activity were assessed in a group of older adults who maintained good physical and cognitive health at years 1, 3, 5, 7, and 9 of the Baltimore Longitudinal Study of Aging neuroimaging study. Each year, these participants underwent PET scans during rest and delayed verbal and figural re...

journal_title：Neurobiology of aging

authors： Beason-Held LL,Kraut MA,Resnick SM

更新日期：2008-04-01 00:00:00

abstract：:In a prospective study of dementia in Flanders (Belgium), we observed a substantial fraction of early-onset dementia patients who did not fulfill the criteria for a specific dementia subtype, leaving the patients without a precise clinical diagnosis. We selected 211 of these patients for genetic testing of causal gene...

journal_title：Neurobiology of aging

authors： Perrone F,Cacace R,Van Mossevelde S,Van den Bossche T,De Deyn PP,Cras P,Engelborghs S,van der Zee J,Van Broeckhoven C

更新日期：2018-09-01 00:00:00