Pattern of brain atrophy rates in autopsy-confirmed dementia with Lewy bodies.

abstract：:Threshold and suprathreshold sensitivities to 13 bitter compounds were determined for 16 young adults (mean age = 27.4 years) and 18 elderly persons (mean age = 81.3 years). Half of the subjects in each age group were tasters of the bitter compound phenylthiocarbamide (PTC) and half were nontasters. Both detection and...

journal_title：Neurobiology of aging

authors： Schiffman SS,Gatlin LA,Frey AE,Heiman SA,Stagner WC,Cooper DC

更新日期：1994-11-01 00:00:00

abstract：:Open field behavior and age-related changes in anterior pituitary corticotropin-releasing hormone (CRH) receptors, as well as plasma ACTH levels, were measured in two inbred rat strains. The strains utilized were Wistar Kyoto (WKY) and Brown-Norway (BN), the former characterized by shorter life-span and hyper-reactivi...

journal_title：Neurobiology of aging

authors： Tizabi Y,Aguilera G,Gilad GM

更新日期：1992-03-01 00:00:00

abstract：:The social species Octodon degus (degu) is the only wild-type South American rodent that develops Alzheimer's-like pathology with age. Here, we evaluated the ability of a natural product (Andrographolide, ANDRO), a diterpene of the labdane family obtained from the Asian plant Andrographis paniculata, to recover the co...

journal_title：Neurobiology of aging

authors： Rivera DS,Lindsay C,Codocedo JF,Morel I,Pinto C,Cisternas P,Bozinovic F,Inestrosa NC

更新日期：2016-10-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder involving the progressive degeneration of motor neurons in the brain and spinal cord. Mitochondrial dysfunction plays a key role in ALS disease progression and has been observed in several ALS cellular and animal models. Here, we show that fibro...

journal_title：Neurobiology of aging

authors： Allen SP,Rajan S,Duffy L,Mortiboys H,Higginbottom A,Grierson AJ,Shaw PJ

更新日期：2014-06-01 00:00:00

abstract：:Mitophagy and mitochondrial biogenesis are 2 pathways that regulate mitochondrial content and metabolism maintaining cellular homeostasis. The imbalance between these opposing processes impairs mitochondrial function and is suggested to be the pathophysiological basis of a variety of neurodegenerative diseases and agi...

journal_title：Neurobiology of aging

authors： Xiong H,Chen S,Lai L,Yang H,Xu Y,Pang J,Su Z,Lin H,Zheng Y

更新日期：2019-07-01 00:00:00

abstract：:Mitochondrial ferritin (FtMt) is believed to play an antioxidant role via iron regulation, and FtMt gene mutation has been reported in age-related macular degeneration (AMD). However, little is known about FtMt's functions in the retina and any links to AMD. In this study, we observed age-related increase in FtMt and ...

journal_title：Neurobiology of aging

authors： Wang X,Yang H,Yanagisawa D,Bellier JP,Morino K,Zhao S,Liu P,Vigers P,Tooyama I

更新日期：2016-11-01 00:00:00

abstract：:White matter is frequently involved in ischemic stroke, and progressive ischemic white matter injuries are associated with various neurologic dysfunctions in the elderly population. Demyelination and oligodendrocyte (OL) loss are prominent features of ischemic white matter injury. Endothelin-1 injection into the inter...

journal_title：Neurobiology of aging

authors： Choi JY,Cui Y,Kang YM,Kim JH,Lee SJ,Kim BG

更新日期：2014-07-01 00:00:00

abstract：:Recently, a mutation in NUS1 has been reported to be associated with Parkinson's disease (PD) in a Chinese population. To further investigate the relationship between NUS1 and sporadic PD, we sequenced all exons and exon-intron boundaries of NUS1 in Chinese Han population including 494 PD patients and 478 healthy cont...

journal_title：Neurobiology of aging

authors： Chen X,Xiao Y,Zhou M,Lin Y,Guo W,Huang S,Qiu J,Peng G,Mo M,Li Z,Zhu X,Xu P

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVE:This longitudinal study used FDG-PET imaging to predict and monitor cognitive decline from normal aging. METHODS:Seventy-seven 50-80-year-old normal (NL) elderly received longitudinal clinical examinations over 6-14 years (561 person-years, mean per person 7.2 years). All subjects had a baseline FDG-PET scan...

journal_title：Neurobiology of aging

authors： Mosconi L,De Santi S,Li J,Tsui WH,Li Y,Boppana M,Laska E,Rusinek H,de Leon MJ

更新日期：2008-05-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease characterized by loss of motor neurons. We have recently identified SOD1 and FUS mutations as the most common causes in a consecutive series of 111 familial ALS pedigrees in Japan. To reveal possible genetic causes for the remaining 51 pat...

journal_title：Neurobiology of aging

authors： Nishiyama A,Niihori T,Warita H,Izumi R,Akiyama T,Kato M,Suzuki N,Aoki Y,Aoki M

更新日期：2017-05-01 00:00:00

abstract：:Individuals with Down syndrome (DS), caused by trisomy of chromosome 21, inevitably develop characteristic Alzheimer's disease (AD) neuropathology, including neuritic plaques, neurofibrillary tangles, and neuronal loss. Amyloid-β protein, the major component of neuritic plaques, is the proteolytic product of amyloid-β...

journal_title：Neurobiology of aging

authors： Wu Y,Deng Y,Zhang S,Luo Y,Cai F,Zhang Z,Zhou W,Li T,Song W

更新日期：2015-01-01 00:00:00

abstract：:We examined whether cognitive reserve (CR) impacts level of, or rate of change in, biomarkers of Alzheimer's disease (AD) and small-vessel cerebrovascular disease in >250 individuals who were cognitively normal and middle-aged and older at the baseline. The four primary biomarker categories commonly examined in studie...

journal_title：Neurobiology of aging

authors： Pettigrew C,Soldan A,Zhu Y,Cai Q,Wang MC,Moghekar A,Miller MI,Singh B,Martinez O,Fletcher E,DeCarli C,Albert M

更新日期：2020-04-01 00:00:00

abstract：:There is developing interest in the potential association between anesthesia and the onset and progression of Alzheimer's disease. Several anesthetics have, thus, been demonstrated to induce tau hyperphosphorylation, an effect mostly mediated by anesthesia-induced hypothermia. Here, we tested the hypothesis that acute...

journal_title：Neurobiology of aging

authors： Whittington RA,Virág L,Gratuze M,Petry FR,Noël A,Poitras I,Truchetti G,Marcouiller F,Papon MA,El Khoury N,Wong K,Bretteville A,Morin F,Planel E

更新日期：2015-08-01 00:00:00

abstract：:Etiologically heterogeneous subgroups of patients with Alzheimer's disease (AD) exist and need to be distinguished so as to better identify genetic causes of familial cases. Furthermore, the presence of AD neuropathology in Down syndrome (trisomy 21) subjects older than 35 years suggests that AD in some cases is cause...

journal_title：Neurobiology of aging

authors： Schapiro MB,Rapoport SI

更新日期：1989-09-01 00:00:00

abstract：:The accumulation of β-amyloid (Aβ) peptide derived from abnormal processing of amyloid precursor protein (APP) is a common pathological hallmark of Alzheimer's disease (AD) brains. In this study, we evaluated the therapeutic effect of berberine (BBR) extracted from Coptis chinensis Franch, a Chinese medicinal herb, on...

journal_title：Neurobiology of aging

authors： Durairajan SS,Liu LF,Lu JH,Chen LL,Yuan Q,Chung SK,Huang L,Li XS,Huang JD,Li M

更新日期：2012-12-01 00:00:00

abstract：:Transcranial electrical stimulation (tES) is a potentially viable tool for boosting cognitive performance in aging. However, most knowledge on tES effects is based on studies involving young adults. Here, we applied tES (transcranial random noise stimulation [tRNS] as an effective stimulation and anodal transcranial d...

journal_title：Neurobiology of aging

authors： Fertonani A,Pirulli C,Bollini A,Miniussi C,Bortoletto M

更新日期：2019-10-01 00:00:00

abstract：:This paper describes regional brain energy metabolism, sensorimotor, and memory functions in mature (12 months) and old (24 months) C57BL/6 mice. Male mice were tested across a variety of sensorimotor procedures and in the Morris water maze before evaluating brain uptake of fluorodeoxyglucose (FDG) in the resting stat...

journal_title：Neurobiology of aging

authors： Uecker A,Gonzalez-Lima F,Cada A,Reiman EM

更新日期：2000-09-01 00:00:00

abstract：:The complement system has been shown to have a critical pathogenetic role in amyotrophic lateral sclerosis (ALS). Recently a C7 variant in rs3792646 was linked to neurodegenerative diseases in a Chinese population. We used whole exome sequencing to evaluate the role of C7 (rs3792646) in ALS in a Chinese cohort with 19...

journal_title：Neurobiology of aging

authors： He J,Fu J,Fan D

更新日期：2020-11-13 00:00:00

abstract：:Beta amyloid (Aβ) is well accepted to play a central role in the pathogenesis of Alzheimer's disease (AD). The present work evaluated the therapeutic effects of low-level laser irradiation (LLI) on Aβ-induced neurotoxicity in rat hippocampus. Aβ 1-42 was injected bilaterally to the hippocampus CA1 region of adult male...

journal_title：Neurobiology of aging

authors： Lu Y,Wang R,Dong Y,Tucker D,Zhao N,Ahmed ME,Zhu L,Liu TC,Cohen RM,Zhang Q

更新日期：2017-01-01 00:00:00

abstract：:Perisynaptic accumulations of amyloid β-protein (Aβ) play a critical role in the synaptic dysfunction underlying the cognitive impairment observed in Alzheimer's disease. The methionine residue at position 35 (Met35) in Aβ is highly subject to oxidation in Alzheimer's disease brains. In hippocampal brain slices we fou...

journal_title：Neurobiology of aging

authors： Ripoli C,Piacentini R,Riccardi E,Leone L,Li Puma DD,Bitan G,Grassi C

更新日期：2013-04-01 00:00:00

abstract：:Recent findings seem to converge towards a unified hypothesis trying to relate Down's syndrome (DS), trisomy 21 and Alzheimer's disease (AD). The majority of DS individuals develop neuropathological characteristics of AD by the age of 40. Previous cytogenetic studies performed by us showed an increased frequency of an...

journal_title：Neurobiology of aging

authors： Migliore L,Boni G,Bernardini R,Trippi F,Colognato R,Fontana I,Coppedè F,Sbrana I

更新日期：2006-05-01 00:00:00

abstract：:Neuroimaging biomarkers differ between patients with early-onset Alzheimer's disease (EOAD) and late-onset Alzheimer's disease (LOAD). Whether these changes reflect cognitive heterogeneity or differences in disease severity is still unknown. This study aimed at investigating changes in neuroimaging biomarkers, accordi...

journal_title：Neurobiology of aging

authors： Aziz AL,Giusiano B,Joubert S,Duprat L,Didic M,Gueriot C,Koric L,Boucraut J,Felician O,Ranjeva JP,Guedj E,Ceccaldi M

更新日期：2017-06-01 00:00:00

abstract：:Cerebral cortex thinning and cerebral blood flow (CBF) reduction are typically observed during normal healthy aging. However, imaging-based age prediction models have primarily used morphological features of the brain. Complementary physiological CBF information might result in an improvement in age estimation. In thi...

journal_title：Neurobiology of aging

authors： MacDonald ME,Williams RJ,Rajashekar D,Stafford RB,Hanganu A,Sun H,Berman AJL,McCreary CR,Frayne R,Forkert ND,Pike GB

更新日期：2020-11-01 00:00:00

abstract：:In Alzheimer's disease (AD) inflammatory processes occur in pathologically vulnerable brain regions. The objective of this study is to compare both the release and the presence of microvessel-associated cytokines in vessels isolated from the brains of AD patients to microvessels from control brains. Microvessels are i...

journal_title：Neurobiology of aging

authors： Grammas P,Ovase R

更新日期：2001-11-01 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by a progressive cognitive decline leading to dementia and involves the deposition of amyloid-beta (Abeta) peptides into senile plaques. Other neuropathological features that accompany progression of the disease include a decrease in synaptic density, neurofibrillary tangles, ...

journal_title：Neurobiology of aging

authors： Dudal S,Krzywkowski P,Paquette J,Morissette C,Lacombe D,Tremblay P,Gervais F

更新日期：2004-08-01 00:00:00

abstract：:Deletions of the mitochondrial DNA (mtDNA) have been shown to accumulate with age in a variety of species regardless of mean or maximal life span. This implies that such mutations are either a molecular biomarker of senescence or that they are more causally linked to senescence itself. One assay that can be used to de...

journal_title：Neurobiology of aging

authors： Melov S,Schneider JA,Coskun PE,Bennett DA,Wallace DC

更新日期：1999-09-01 00:00:00

abstract：:Results from basic and clinical studies demonstrate that stress and depression decrease neurotrophic factor expression and neurogenesis in brain, and that antidepressant treatment blocks or reverses these effects, leading to a neurotrophic hypothesis of depression. Neurotrophic factor expression and neurogenesis are a...

journal_title：Neurobiology of aging

authors： Duman RS

更新日期：2005-12-01 00:00:00

abstract：:Activated microglia are instrumental to neurodegeneration in Parkinson's disease (PD). Fractalkine, as an exclusive ligand for CX3CR1 expressed on microglia, has recently been reported to be released out by neurons, and induce microglial activation as a neuron-to-glia signal in the spinal cord. However, the role of fr...

journal_title：Neurobiology of aging

authors： Shan S,Hong-Min T,Yi F,Jun-Peng G,Yue F,Yan-Hong T,Yun-Ke Y,Wen-Wei L,Xiang-Yu W,Jun M,Guo-Hua W,Ya-Ling H,Hua-Wei L,Ding-Fang C

更新日期：2011-03-01 00:00:00

abstract：:In simple systems, lifespan can be extended by various methods including dietary restriction, mutations in the insulin/insulin-like growth factor (IGF) pathway or mitochondria among other processes. It is widely held that the mechanisms that extend lifespan may be adapted for diminishing age-associated pathologies. We...

journal_title：Neurobiology of aging

authors： Tauffenberger A,Julien C,Parker JA

更新日期：2013-09-01 00:00:00

abstract：:Exercise has emerged as a powerful variable that can improve cognitive function and delay age-associated cognitive decline and Alzheimer's disease (AD); however, the underlying mechanisms are poorly understood. To determine if protective mechanisms may occur at the transcriptional level, we used microarrays to investi...

journal_title：Neurobiology of aging

authors： Berchtold NC,Prieto GA,Phelan M,Gillen DL,Baldi P,Bennett DA,Buchman AS,Cotman CW

更新日期：2019-06-01 00:00:00