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Cognitive reserve and rate of change in Alzheimer's and cerebrovascular disease biomarkers among cognitively normal individuals.

Abstract：

:We examined whether cognitive reserve (CR) impacts level of, or rate of change in, biomarkers of Alzheimer's disease (AD) and small-vessel cerebrovascular disease in >250 individuals who were cognitively normal and middle-aged and older at the baseline. The four primary biomarker categories commonly examined in studies of AD were measured longitudinally: cerebrospinal fluid measures of amyloid (A) and tau (T); cerebrospinal fluid and neuroimaging measures of neuronal injury (N); and neuroimaging measures of white matter hyperintensities (WMHs) to assess cerebrovascular pathology (V). CR was indexed by a composite score including years of education, reading, and vocabulary test performance. Higher CR was associated with lower levels of WMHs, particularly among those who subsequently progressed from normal cognition to MCI. CR was not associated with WMH trajectories. In addition, CR was not associated with either levels of, or rate of change in, A/T/N biomarkers. This may suggest that higher CR is associated with lifestyle factors that reduce levels of cerebrovascular disease, allowing individuals with higher CR to better tolerate other types of pathology.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

Pettigrew C,Soldan A,Zhu Y,Cai Q,Wang MC,Moghekar A,Miller MI,Singh B,Martinez O,Fletcher E,DeCarli C,Albert M

doi

10.1016/j.neurobiolaging.2019.12.003

subject

Has Abstract

pub_date

2020-04-01 00:00:00

pages

33-41

eissn

0197-4580

issn

1558-1497

pii

S0197-4580(19)30431-2

journal_volume

88

pub_type

杂志文章

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