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Developmental and vascular risk factors for Alzheimer's disease.

Abstract：

:To investigate developmental and vascular risk factors for Alzheimer's disease (AD), we examined 90 incident cases of probable AD in a cohort of 1859 individuals followed prospectively for six years. The presence of the APOE-epsilon4 allele was the strongest risk factor, and with increasing survival age, the effect of epsilon4 diminished. Among epsilon4 positives, developmental risk factors such as smaller head circumference (< or =54.4 cm) and having more than four children in the household at age 2-3 were independently associated with incident AD (hazard ratio (HR)=2.6 (95% CI 1.04-6.3) and 3.3 (1.2-9.2), respectively). Among epsilon4 negatives, vascular risk factors were related to AD risk (self-reported diagnoses of transient ischemic attack and diabetes (HR=5.1, 95% CI 1.7-15.5; HR 3.3, 95% CI 1.4-8.1)). These findings indicate that clinical AD is a result of early life as well as later life risk factors, and that genetic predisposition to the disease may modify the constellation of predictors.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

Borenstein AR,Wu Y,Mortimer JA,Schellenberg GD,McCormick WC,Bowen JD,McCurry S,Larson EB

doi

10.1016/j.neurobiolaging.2004.04.010

subject

Has Abstract

pub_date

2005-03-01 00:00:00

pages

325-34

issue

3

eissn

0197-4580

issn

1558-1497

pii

S0197-4580(04)00271-4

journal_volume

26

pub_type

杂志文章

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