Accumulation of amyloid beta protein in transgenic mice.

abstract：:Striatal dopamine (DA) and metabolite (DOPAC) levels in 8-, 21-, 52- and 104-week-old C57BL mice were compared with those in 11-week-old mice, 20 days after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment. DA and DOPAC concentrations expressed relative to striatal wet weight did not change with age. In c...

journal_title：Neurobiology of aging

authors： Greenwood CE,Tatton WG,Seniuk NA,Biddle FG

更新日期：1991-09-01 00:00:00

abstract：:This study modeled predementia Alzheimer's disease clinical trials. Longitudinal data from cognitively normal (CN) and mild cognitive impairment (MCI) participants in the Alzheimer's Disease Neuroimaging Initiative were used to calculate sample size requirements for trials using outcome measures, including the Clinica...

journal_title：Neurobiology of aging

authors： Grill JD,Di L,Lu PH,Lee C,Ringman J,Apostolova LG,Chow N,Kohannim O,Cummings JL,Thompson PM,Elashoff D,Alzheimer's Disease Neuroimaging Initiative.

更新日期：2013-01-01 00:00:00

abstract：:Studies regarding different viruses of the herpes family, such as cytomegalovirus (CMV), Epstein-Barr virus (EBV), or human herpes virus 6 (HHV-6) in Alzheimer's disease (AD) are scarce. DNA from peripheral blood leukocytes (PBL) and brain samples were analyzed for the presence of CMV, EBV, or HHV-6. All samples were ...

journal_title：Neurobiology of aging

authors： Carbone I,Lazzarotto T,Ianni M,Porcellini E,Forti P,Masliah E,Gabrielli L,Licastro F

更新日期：2014-01-01 00:00:00

abstract：:White matter hyperintensities (WMH) are generally considered to be associated with cerebral small vessel disease, especially, in older age. Although significant sex differences have been reported in the severity of WMH, it is not yet known if the risk factors for WMH differ in men and women. In this study, magnetic re...

journal_title：Neurobiology of aging

authors： Alqarni A,Jiang J,Crawford JD,Koch F,Brodaty H,Sachdev P,Wen W

更新日期：2020-11-10 00:00:00

abstract：:Extracellular senile plaques (SPs) are hallmark brain lesions of sporadic Alzheimer's disease (AD) and the likely consequence of genetic mutations that cause familial AD by increasing production of amyloidogenic amyloid-beta (Abeta). Although Abeta vaccines and inhibitors of amyloidogenic secretases are potential AD t...

journal_title：Neurobiology of aging

authors： Lee VM

更新日期：2002-11-01 00:00:00

abstract：:Chronic treatment (21 days) with phosphatidylserine (BC-PS) partially restored the reduced density of muscarinic cholinergic receptors in several regions of the aged (18 months) mouse brain. The effect was similar whether 3H-QNB or 3H-NMS was used as radioligand. The affinity of both radioligands was not altered by BC...

journal_title：Neurobiology of aging

authors： Gelbmann CM,Müller WE

更新日期：1992-01-01 00:00:00

abstract：:Mural cells (smooth muscle cells and pericytes) regulate blood flow and contribute to vessel stability. We examined whether mural cell changes accompany age-related alterations in the microvasculature of the central nervous system. The retinas of young adult and aged Wistar rats were subjected to immunohistofluorescen...

journal_title：Neurobiology of aging

authors： Hughes S,Gardiner T,Hu P,Baxter L,Rosinova E,Chan-Ling T

更新日期：2006-12-01 00:00:00

abstract：:Alzheimer's disease (AD) is generally considered to be a disorder primarily affecting memory. It is increasingly recognized that the clinical presentation or "cognitive phenotype" is variable. The apolipoprotein E ε4 (APOE ε4) allele has been associated with an amnestic presentation, but does not appear to fully expla...

journal_title：Neurobiology of aging

authors： Vardy ER,Brown K,Stopford CL,Thompson JC,Richardson AM,Neary D,Kalsheker N,Morgan K,Mann DM,Snowden JS

更新日期：2012-07-01 00:00:00

abstract：:The brains of 14 rhesus monkeys (Macaca mulatta) between 4 and 35 years old were examined to determine the effects of aging on the thickness, neuronal frequency, fine structure, surface area, and volume of striate cortex. The effects of aging were ascertained by comparing the striate cortex in the six monkeys between ...

journal_title：Neurobiology of aging

authors： Peters A,Nigro NJ,McNally KJ

更新日期：1997-01-01 00:00:00

abstract：:Aging, amyloid deposition, and tau-related pathology are key contributors to the onset and progression of Alzheimer's disease (AD). However, AD is also associated with brain hypometabolism and deficits of mitochondrial bioenergetics. Plasma acylcarnitines (ACCs) are indirect indices of altered fatty acid beta-oxidatio...

journal_title：Neurobiology of aging

authors： Ciavardelli D,Piras F,Consalvo A,Rossi C,Zucchelli M,Di Ilio C,Frazzini V,Caltagirone C,Spalletta G,Sensi SL

更新日期：2016-07-01 00:00:00

abstract：:Genome-wide association studies (GWASs) have been effective approaches to dissect common genetic variability underlying complex diseases in a systematic and unbiased way. Recently, GWASs have led to the discovery of over 20 susceptibility loci for Alzheimer's disease (AD). Despite the evidence showing the contribution...

journal_title：Neurobiology of aging

authors： Sassi C,Nalls MA,Ridge PG,Gibbs JR,Ding J,Lupton MK,Troakes C,Lunnon K,Al-Sarraj S,Brown KS,Medway C,Clement N,Lord J,Turton J,Bras J,Almeida MR,ARUK Consortium.,Holstege H,Louwersheimer E,van der Flier WM,Schelte

更新日期：2016-10-01 00:00:00

abstract：:Humans carrying the prevalent rs9939609 A allele of the fat mass and obesity-associated (FTO) gene are more susceptible to developing obesity than noncarries. Recently, polymorphisms in the FTO gene of elderly subjects have also been linked to a reduced volume in the frontal lobe as well as increased risk for incident...

journal_title：Neurobiology of aging

authors： Benedict C,Jacobsson JA,Rönnemaa E,Sällman-Almén M,Brooks S,Schultes B,Fredriksson R,Lannfelt L,Kilander L,Schiöth HB

更新日期：2011-06-01 00:00:00

abstract：:Progranulin (GRN) is a secreted growth factor involved in various cellular functions, and loss-of-function mutations are a major cause of frontotemporal lobar degeneration (FTLD) with TDP-43 positive pathology. Most FTLD-related GRN mutations are nonsense mutations resulting in reduced GRN expression. Nonsynonymous GR...

journal_title：Neurobiology of aging

authors： Kleinberger G,Capell A,Brouwers N,Fellerer K,Sleegers K,Cruts M,Van Broeckhoven C,Haass C

更新日期：2016-03-01 00:00:00

abstract：:As a major characteristic of aging process, neuroinflammation is involved in the pathogenesis of several aging-related diseases including Alzheimer's disease (AD). Triggering receptor expressed on myeloid cells 2 (TREM2) is a newly identified risk gene for AD, which regulates inflammatory process in peripheral tissues...

journal_title：Neurobiology of aging

authors： Jiang T,Yu JT,Zhu XC,Tan MS,Gu LZ,Zhang YD,Tan L

更新日期：2014-06-01 00:00:00

abstract：:The supraoptic nucleus of the F344 rat shows an age-related dendritic regression. In order to determine whether this previously observed dendritic regression may have been related to extrinsic (to the cell) hormonal, neurotoxic, or other circulating factors unique to the hypothalamus of older brains, we conducted a qu...

journal_title：Neurobiology of aging

authors： Kaplan AS,Gash DM,Flood DG,Coleman PD

更新日期：1985-10-01 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by the presence of β-amyloid (Aβ) deposition and neurodegeneration. To seek for signs of such pathologies, we compared regional biomarker degrees and patterns of Aβ deposition, glucose hypometabolism, and gray matter volume (GMV) reduction in 3 groups at risk of AD. In elderly...

journal_title：Neurobiology of aging

authors： Wirth M,Bejanin A,La Joie R,Arenaza-Urquijo EM,Gonneaud J,Landeau B,Perrotin A,Mézenge F,de La Sayette V,Desgranges B,Chételat G

更新日期：2018-03-01 00:00:00

abstract：:Decreased levels of cerebrospinal fluid (CSF) Abeta42 is a diagnostic marker of Alzheimer's disease. To clarify the biological basis of this marker, the physiological alterations of CSF Abeta40 and Abeta42 by aging were studied. CSF samples from 92 normal subjects between 8 and 89 years old were measured using a speci...

journal_title：Neurobiology of aging

authors： Shoji M,Kanai M,Matsubara E,Tomidokoro Y,Shizuka M,Ikeda Y,Ikeda M,Harigaya Y,Okamoto K,Hirai S

更新日期：2001-03-01 00:00:00

abstract：:The H1 MAPT haplotype in the 17q21 chromosomal region has been associated with several neurodegenerative diseases. Some reports have suggested that there is an association between genetic variants within the H1 haplotype with Parkinson's disease (PD), progressive supranuclear palsy (PSP) and corticobasal degeneration ...

journal_title：Neurobiology of aging

authors： Ezquerra M,Pastor P,Gaig C,Vidal-Taboada JM,Cruchaga C,Muñoz E,Martí MJ,Valldeoriola F,Aguilar M,Calopa M,Hernandez-Vara J,Tolosa E

更新日期：2011-03-01 00:00:00

abstract：:The activities of presenilin 1 (PS1) and 2 modulate the proteolytic processing of amyloid precursor proteins to produce Abeta1-42, and mutations in these proteins are associated with an accelerated rate of Abeta deposition. PS1 and PS2 themselves are subject to a highly-regulated endoproteolytic cleavage to generate s...

journal_title：Neurobiology of aging

authors： Borchelt DR,Lee MK,Gonzales V,Slunt HH,Ratovitski T,Jenkins NA,Copeland NG,Price DL,Sisodia SS

更新日期：2002-03-01 00:00:00

abstract：:Vascular risk factors have been implicated in the pathogenesis of vascular dementia and Alzheimer's disease. The identification of a novel vascular disease susceptibility locus at 9p21.3 has recently generated great interest. In the present study, we sought to determine whether a common genetic variant (tagged by rs13...

journal_title：Neurobiology of aging

authors： Emanuele E,Lista S,Ghidoni R,Binetti G,Cereda C,Benussi L,Maletta R,Bruni AC,Politi P

更新日期：2011-07-01 00:00:00

abstract：:The complement system has been shown to have a critical pathogenetic role in amyotrophic lateral sclerosis (ALS). Recently a C7 variant in rs3792646 was linked to neurodegenerative diseases in a Chinese population. We used whole exome sequencing to evaluate the role of C7 (rs3792646) in ALS in a Chinese cohort with 19...

journal_title：Neurobiology of aging

authors： He J,Fu J,Fan D

更新日期：2020-11-13 00:00:00

abstract：:Cross-sectional studies have found declines in most measures of oculomotor function in older subjects compared to young controls, but no prior study has followed the same subjects over time. We measured saccade peak velocity, saccade delay time, smooth pursuit, optokinetic nystagmus (OKN), visual-vestibular-ocular-ref...

journal_title：Neurobiology of aging

authors： Kerber KA,Ishiyama GP,Baloh RW

更新日期：2006-09-01 00:00:00

abstract：:The internal carotid artery termination (CAT) ends in a T-shaped bifurcation just below the substantia innominata (SI), which contains cognitively strategic cholinergic neurons and undergoes atrophy in Alzheimer's disease (AD). This study investigated whether an elongated CAT with possible resulting encroachment into ...

journal_title：Neurobiology of aging

authors： Gao FQ,Pettersen JA,Bocti C,Nestor SM,Kiss A,Black SE

更新日期：2013-07-01 00:00:00

abstract：:In Alzheimer's disease, the contribution of inflammation is still controversially discussed. The aim of this study was to identify a particular immune profile in the peripheral blood (PB) and cerebrospinal fluid (CSF) in patients with mild Alzheimer's disease (mAD) and mild cognitive impairment (MCI) and its potential...

journal_title：Neurobiology of aging

authors： Lueg G,Gross CC,Lohmann H,Johnen A,Kemmling A,Deppe M,Groger J,Minnerup J,Wiendl H,Meuth SG,Duning T

更新日期：2015-01-01 00:00:00

abstract：:I propose that North American investigators who depend largely on individual external grants would benefit from the creation of regional facilities designed to support studies of aging in transgenic models. In general, academic institutions cannot achieve the most cost effectiveness because their facilities are not de...

journal_title：Neurobiology of aging

authors： Finch CE

更新日期：1999-03-01 00:00:00

abstract：:Recent reports have suggested that beta-amyloid (A beta) species of variable length C-termini are differentially deposited within early and late-stage plaques and the cerebrovasculature. Specifically, longer C-terminal length A beta 42/3 fragments (i.e., A beta forms extending to residues 42 and/or 43) are thought to ...

journal_title：Neurobiology of aging

authors： Cummings BJ,Satou T,Head E,Milgram NW,Cole GM,Savage MJ,Podlisny MB,Selkoe DJ,Siman R,Greenberg BD,Cotman CW

更新日期：1996-07-01 00:00:00

abstract：:The sporadic form of Alzheimer disease, late onset Alzheimer's disease (LOAD), is a multifactorial disease; a strong link between nutritional and genetic factors with normal aging and dementia is supported by studies on nutrition, metabolism, and neurodegeneration. Specifically, the involvement of homocysteine (HCY) a...

journal_title：Neurobiology of aging

authors： Fuso A,Scarpa S

更新日期：2011-07-01 00:00:00

abstract：:Cortisol and ACTH exhibit circadian rhythmicity, peaking in the early morning. These peaks are associated with increased activity and alertness. We sought to determine whether self-reported daily rhythms predict outcome of a.m. and p.m. CRH challenge in elderly subjects. We surveyed 96 elderly subjects to determine da...

journal_title：Neurobiology of aging

authors： Blazer DG,Malmrose LC,Wallsten SM,Nemeroff CB,Reed DA,Ritchie JC,Tyrey ME

更新日期：1993-01-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS; Lou Gehrig's disease) is a progressive debilitating neurodegenerative disease with no cure. We propose a novel molecular model for the pathogenesis of ALS that involves an adenosine triphosphate (ATP)-dependent muscle neuronal lactate shuttle (MNLS) at the neuromuscular junction (NM...

journal_title：Neurobiology of aging

authors： Vadakkadath Meethal S,Atwood CS

更新日期：2012-03-01 00:00:00

abstract：:Fractal dimensionality (FD) measures the complexity within the folds and ridges of cortical and subcortical structures. We tested the degree that FD might provide a new perspective on the atrophy-compensation hypothesis: age or disease-related atrophy causes a compensatory neural response in the form of increased brai...

journal_title：Neurobiology of aging

authors： McDonough IM,Madan CR

更新日期：2020-11-14 00:00:00