Aging and infection reduce expression of specific brain-derived neurotrophic factor mRNAs in hippocampus.


:Aging increases the likelihood of cognitive decline after negative life events such as infection or injury. We have modeled this increased vulnerability in aged (24-month-old), but otherwise unimpaired F344xBN rats. In these animals, but not in younger (3-month-old) counterparts, a single intraperitoneal injection of E. coli leads to specific deficits in long-term memory and long-lasting synaptic plasticity in hippocampal area CA1-processes strongly dependent on brain-derived neurotrophic factor (BDNF). Here we have investigated the effects of age and infection on basal and fear-conditioning-stimulated expression of Bdnf in hippocampus. We performed in situ hybridization with 6 probes recognizing: total (pan-)BDNF mRNA, the 4 predominant 5' exon-specific transcripts (I, II, IV, and VI), and BDNF mRNAs with a long 3' untranslated region (3' UTR). In CA1, aging reduced basal levels and fear-conditioning-induced expression of total BDNF mRNA, exon IV-specific transcripts, and transcripts with long 3' UTRs; effects of infection were similar and sometimes compounded the effects of aging. In CA3, aging reduced all of the transcripts to some degree; infection had no effect. Effects in dentate were minimal. Northern blot analysis confirmed an aging-associated loss of total BDNF mRNA in areas CA1 and CA3, and revealed a parallel, preferential loss of BDNF mRNA transcripts with long 3' UTRs.


Neurobiol Aging


Neurobiology of aging


Chapman TR,Barrientos RM,Ahrendsen JT,Hoover JM,Maier SF,Patterson SL




Has Abstract


2012-04-01 00:00:00














  • Efficacy of MEM 1003, a novel calcium channel blocker, in delay and trace eyeblink conditioning in older rabbits.

    abstract::Eyeblink conditioning is a relatively simple form of associative learning that shows neurobiological and behavioral parallels across several species, including humans. Aged subjects acquire eyeblink conditioning more slowly than young ones. In addition, eyeblink conditioning effectively discriminates patients with Alz...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Rose GM,Ong VS,Woodruff-Pak DS

    更新日期:2007-05-01 00:00:00

  • An attenuated immune response by Schwann cells and macrophages inhibits nerve regeneration in aged rats.

    abstract::Although peripheral nerves are capable of regeneration, advanced age decreases the potential for functional recovery after injury. The cellular mechanisms for this are not currently understood. Here, we performed sciatic nerve grafting with young (2 months old) and aged (18 months old) Brown-Norway male rats, in which...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Scheib JL,Höke A

    更新日期:2016-09-01 00:00:00

  • Medium-chain plasma acylcarnitines, ketone levels, cognition, and gray matter volumes in healthy elderly, mildly cognitively impaired, or Alzheimer's disease subjects.

    abstract::Aging, amyloid deposition, and tau-related pathology are key contributors to the onset and progression of Alzheimer's disease (AD). However, AD is also associated with brain hypometabolism and deficits of mitochondrial bioenergetics. Plasma acylcarnitines (ACCs) are indirect indices of altered fatty acid beta-oxidatio...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Ciavardelli D,Piras F,Consalvo A,Rossi C,Zucchelli M,Di Ilio C,Frazzini V,Caltagirone C,Spalletta G,Sensi SL

    更新日期:2016-07-01 00:00:00

  • MicroRNA-494 reduces DJ-1 expression and exacerbates neurodegeneration.

    abstract::Oxidative stress is believed to be a significant cause of Parkinson's disease (PD). DJ-1 is thought to be an oxidative sensor that protects cells from oxidative insult. It was reported that the level of total DJ-1 protein was significantly reduced in the substantia nigra of sporadic PD patients, suggesting that abnorm...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Xiong R,Wang Z,Zhao Z,Li H,Chen W,Zhang B,Wang L,Wu L,Li W,Ding J,Chen S

    更新日期:2014-03-01 00:00:00

  • Oxidative modification of proteins in the frontal cortex of Alzheimer's disease brain.

    abstract::There is a large body of evidence highlighting the importance of oxidative stress in the pathogenesis of Alzheimer's disease (AD). We have previously standardised a method that can be applied to study oxidative changes in individual brain proteins by using two-dimensional oxyblots (Korolainen MA, Goldsteins G, Alafuzo...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Korolainen MA,Goldsteins G,Nyman TA,Alafuzoff I,Koistinaho J,Pirttilä T

    更新日期:2006-01-01 00:00:00

  • Is M129V of PRNP gene associated with Alzheimer's disease? A case-control study and a meta-analysis.

    abstract::The methionine/valine (M/V) polymorphism at codon 129 within the prion protein gene (PRNP) represents a known risk factor for Creutzfeldt-Jakob disease (CJD). Few authors reported also the effects of this polymorphism on the risk of Alzheimer's disease (AD), although with controversial results. To better clarify this ...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章,meta分析


    authors: Del Bo R,Scarlato M,Ghezzi S,Martinelli-Boneschi F,Fenoglio C,Galimberti G,Galbiati S,Virgilio R,Galimberti D,Ferrarese C,Scarpini E,Bresolin N,Comi GP

    更新日期:2006-05-01 00:00:00

  • Evidence for an association between KIBRA and late-onset Alzheimer's disease.

    abstract::We recently reported evidence for an association between the individual variation in normal human episodic memory and a common variant of the KIBRA gene, KIBRA rs17070145 (T-allele). Since memory impairment is a cardinal clinical feature of Alzheimer's disease (AD), we investigated the possibility of an association be...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Corneveaux JJ,Liang WS,Reiman EM,Webster JA,Myers AJ,Zismann VL,Joshipura KD,Pearson JV,Hu-Lince D,Craig DW,Coon KD,Dunckley T,Bandy D,Lee W,Chen K,Beach TG,Mastroeni D,Grover A,Ravid R,Sando SB,Aasly JO,Heun R

    更新日期:2010-06-01 00:00:00

  • GRN deletion in familial frontotemporal dementia showing association with clinical variability in 3 familial cases.

    abstract::Progranulin (GRN) gene mutations have been genetically associated with frontotemporal dementia (FTD) and are present in about 23% of patients with familial FTD. However, the neurobiology of this secreted glycoprotein remains unclear. Here, we report the identification of 3 pedigrees of Southern Italian extraction in w...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Milan G,Napoletano S,Pappatà S,Gentile MT,Colucci-D'Amato L,Della Rocca G,Maciag A,Rossetti CP,Fucci L,Puca A,Grossi D,Postiglione A,Vitale E

    更新日期:2017-05-01 00:00:00

  • Locus coeruleus neurofibrillary degeneration in aging, mild cognitive impairment and early Alzheimer's disease.

    abstract::Neurofibrillary degeneration in the nucleus basalis and a loss of its cortical cholinergic projections are prominent components of the neuropathology in Alzheimer's disease (AD). The AD brain is also associated with a degeneration of the noradrenergic projections arising from the nucleus locus coeruleus (LC), but the ...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Grudzien A,Shaw P,Weintraub S,Bigio E,Mash DC,Mesulam MM

    更新日期:2007-03-01 00:00:00

  • Opposite patterns of age-associated changes in neurons and glial cells of the thalamus of human brain.

    abstract::In an autopsy series of 19 individuals, age-ranged 24-94, a relatively age-spared region, the anterior-ventral thalamus, was analyzed by immunohistochemical techniques to visualize neurons (neurofilament protein), astrocytes (glial fibrillary acidic protein), microglial cells (CD68) and amyloid precursor protein. The ...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Guidolin D,Zunarelli E,Genedani S,Trentini GP,De Gaetani C,Fuxe K,Benegiamo C,Agnati LF

    更新日期:2008-06-01 00:00:00

  • Visuomotor task acquisition is reduced by priming paired associative stimulation in older adults.

    abstract::Transcranial magnetic stimulation may represent an effective means for improving motor function in the elderly. The aim of this study was therefore to investigate the effects of paired associative stimulation (PAS; a plasticity-inducing transcranial magnetic stimulation paradigm) on acquisition of a novel visuomotor t...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Opie GM,Hand BJ,Coxon JP,Ridding MC,Ziemann U,Semmler JG

    更新日期:2019-09-01 00:00:00

  • Candidate gene analysis for Alzheimer's disease in adults with Down syndrome.

    abstract::Individuals with Down syndrome (DS) overexpress many genes on chromosome 21 due to trisomy and have high risk of dementia due to the Alzheimer's disease (AD) neuropathology. However, there is a wide range of phenotypic differences (e.g., age at onset of AD, amyloid β levels) among adults with DS, suggesting the import...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Lee JH,Lee AJ,Dang LH,Pang D,Kisselev S,Krinsky-McHale SJ,Zigman WB,Luchsinger JA,Silverman W,Tycko B,Clark LN,Schupf N

    更新日期:2017-08-01 00:00:00

  • KIBRA gene variants are associated with episodic memory in healthy elderly.

    abstract::The first hypothesis free genome wide association study on cognition recently revealed the thus far unknown association of a single nucleotide polymorphism (SNP) of the KIBRA gene with episodic memory in healthy young and middle aged volunteers. Here, we report the first independent replication of this finding in an i...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Schaper K,Kolsch H,Popp J,Wagner M,Jessen F

    更新日期:2008-07-01 00:00:00

  • Rare variants in SQSTM1 and VCP genes and risk of sporadic inclusion body myositis.

    abstract::Genetic factors have been suggested to be involved in the pathogenesis of sporadic inclusion body myositis (sIBM). Sequestosome 1 (SQSTM1) and valosin-containing protein (VCP) are 2 key genes associated with several neurodegenerative disorders but have yet to be thoroughly investigated in sIBM. A candidate gene analys...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Gang Q,Bettencourt C,Machado PM,Brady S,Holton JL,Pittman AM,Hughes D,Healy E,Parton M,Hilton-Jones D,Shieh PB,Needham M,Liang C,Zanoteli E,de Camargo LV,De Paepe B,De Bleecker J,Shaibani A,Ripolone M,Violano R,Mo

    更新日期:2016-11-01 00:00:00

  • Conversion of MCI to dementia: Role of proton magnetic resonance spectroscopy.

    abstract::Mild cognitive impairment (MCI) represents a heterogeneous group of cognitive disturbances at high risk of dementia. The amnestic subtype (aMCI) might be a prodromal state of Alzheimer's disease (AD). The aim of this study is the identification, by proton magnetic resonance spectroscopy (1H MRS), of modifications in b...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Metastasio A,Rinaldi P,Tarducci R,Mariani E,Feliziani FT,Cherubini A,Pelliccioli GP,Gobbi G,Senin U,Mecocci P

    更新日期:2006-07-01 00:00:00

  • Acetylcholinesterase promotes beta-amyloid plaques in cerebral cortex.

    abstract::Studies in vitro have suggested that acetylcholinesterase (AChE) may interact with beta-amyloid to promote deposition of amyloid plaques in the brain of patients with Alzheimer's disease. To test that hypothesis in vivo, we crossed Tg2576 mice, which express human amyloid precursor protein and develop plaques at 9 mon...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Rees T,Hammond PI,Soreq H,Younkin S,Brimijoin S

    更新日期:2003-10-01 00:00:00

  • Profile of pathogenic proteins in total circulating extracellular vesicles in mild cognitive impairment and during the progression of Alzheimer's disease.

    abstract::Accumulating evidence suggests that the propagation of hyperphosphorylation of tau protein and the amyloid-β peptide can be mediated by extracellular vesicles (EVs) and be associated with the onset and the progression of Alzheimer's disease (AD). As EVs may transfer between the brain and the blood, we have thus hypoth...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Perrotte M,Haddad M,Le Page A,Frost EH,Fulöp T,Ramassamy C

    更新日期:2020-02-01 00:00:00

  • Age- and stage-dependent glyoxalase I expression and its activity in normal and Alzheimer's disease brains.

    abstract::The reaction of lysine and arginine residues of proteins with 1,2-dicarbonyl compounds result in the formation of advanced glycation end products (AGEs). Accumulation of AGEs is a characteristic feature of the aging brain and contributes to the development of neurodegenerative diseases such as Alzheimer's disease (AD)...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Kuhla B,Boeck K,Schmidt A,Ogunlade V,Arendt T,Münch G,Lüth HJ

    更新日期:2007-01-01 00:00:00

  • Serum leptin and cognitive function in people with type 2 diabetes.

    abstract::People with obesity and type 2 diabetes are at increased risk of cognitive impairment. We aimed to investigate the association of leptin with cognitive abilities in an elderly population with type 2 diabetes. We performed a cross-sectional study of 1057 men and women aged 60-75 years with type 2 diabetes living in Lot...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Labad J,Price JF,Strachan MW,Deary IJ,Seckl JR,Sattar N,Reynolds RM,Edinburgh Type 2 Diabetes Study Investigators.

    更新日期:2012-12-01 00:00:00

  • Age-related changes in glial fibrillary acidic protein mRNA in the mouse brain.

    abstract::Several RNA sequences were tested for age-related changes in prevalence levels in the mouse cerebral cortex, hippocampus, and cerebellum. In all three regions, there were increased levels of RNA for glial fibrillary acidic protein, an astrocyte-specific protein, by RNA gel-blot analysis and by a solution hybridization...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Goss JR,Finch CE,Morgan DG

    更新日期:1991-03-01 00:00:00

  • Rhythmicity and response to A.M. and P.M. CRH challenge in elderly subjects.

    abstract::Cortisol and ACTH exhibit circadian rhythmicity, peaking in the early morning. These peaks are associated with increased activity and alertness. We sought to determine whether self-reported daily rhythms predict outcome of a.m. and p.m. CRH challenge in elderly subjects. We surveyed 96 elderly subjects to determine da...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Blazer DG,Malmrose LC,Wallsten SM,Nemeroff CB,Reed DA,Ritchie JC,Tyrey ME

    更新日期:1993-01-01 00:00:00

  • Glucose metabolism and gray-matter concentration in apolipoprotein E ε4 positive normal subjects.

    abstract::Apolipoprotein E (ApoE) ε4 is known as a genetic risk factor for Alzheimer's disease (AD). This study investigated the prevalence of imaging abnormalities suggestive of AD in cognitively normal ApoE ε4 carriers using (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET) and voxel-based morphometry (VBM). F...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Samuraki M,Matsunari I,Chen WP,Shima K,Yanase D,Takeda N,Matsuda H,Yamada M

    更新日期:2012-10-01 00:00:00

  • Chronic treatment with phosphatidylserine restores muscarinic cholinergic receptor deficits in the aged mouse brain.

    abstract::Chronic treatment (21 days) with phosphatidylserine (BC-PS) partially restored the reduced density of muscarinic cholinergic receptors in several regions of the aged (18 months) mouse brain. The effect was similar whether 3H-QNB or 3H-NMS was used as radioligand. The affinity of both radioligands was not altered by BC...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Gelbmann CM,Müller WE

    更新日期:1992-01-01 00:00:00

  • A systematic review and meta-analysis of rTMS effects on cognitive enhancement in mild cognitive impairment and Alzheimer's disease.

    abstract::Repetitive transcranial magnetic stimulation (rTMS), a noninvasive brain stimulation technique, has emerged as a promising treatment for mild cognitive impairment (MCI) and Alzheimer's disease (AD). Currently, however, the effectiveness of this therapy is unclear because of the low statistical power and heterogeneity ...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章,meta分析


    authors: Chou YH,Ton That V,Sundman M

    更新日期:2020-02-01 00:00:00

  • Retinal pathology in Alzheimer's disease. II. Regional neuron loss and glial changes in GCL.

    abstract::Detailed analyses of neuronal and astrocyte cell numbers in the ganglion cell layer (GCL) of whole-mounted peripheral retinas from 16 Alzheimer's disease (AD) and 11 control eyes (11 and 9 cases, respectively) demonstrate extensive neuronal loss throughout the entire retina in AD as compared to control eyes. The obser...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Blanks JC,Schmidt SY,Torigoe Y,Porrello KV,Hinton DR,Blanks RH

    更新日期:1996-05-01 00:00:00

  • Distortions in rest-activity rhythm in aging relate to white matter hyperintensities.

    abstract::Distortions in the rest-activity rhythm in aging are commonly observed. Neurodegenerative changes of the suprachiasmatic nucleus have been proposed to underlie this disrupted rhythm. However, based on previous studies, it can be proposed that white matter hyperintensities (WMH) may also play a role in the altered rest...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Oosterman J,van Harten B,Vogels R,Gouw A,Weinstein H,Scheltens P,Scherder E

    更新日期:2008-08-01 00:00:00

  • EEG correlates of visual short-term memory in older age vary with adult lifespan cognitive development.

    abstract::Visual short-term memory (vSTM) is a cognitive resource that declines with age. This study investigated whether electroencephalography (EEG) correlates of vSTM vary with cognitive development over individuals' lifespan. We measured vSTM performance and EEG in a lateralized whole-report task in a healthy birth cohort, ...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Wiegand I,Lauritzen MJ,Osler M,Mortensen EL,Rostrup E,Rask L,Richard N,Horwitz A,Benedek K,Vangkilde S,Petersen A

    更新日期:2018-02-01 00:00:00

  • Dietary restriction does not alter retinal aging in the Fischer 344 rat.

    abstract::In the present study, the effects of long-term dietary restriction (60% of the calories in the ad lib diet, beginning at 16 weeks of age) on quantitative morphometric measures and histopathologic indications of aging have been investigated in the retina of Fischer 344 male rats. The animals were maintained by the NIA ...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: O'Steen WK,Landfield PW

    更新日期:1991-09-01 00:00:00

  • 18F-fluorodeoxyglucose positron emission tomography, aging, and apolipoprotein E genotype in cognitively normal persons.

    abstract::Our objective was to examine associations between glucose metabolism, as measured by (18)F-fluorodeoxyglucose positron emission tomography (FDG PET), and age and to evaluate the impact of carriage of an apolipoprotein E (APOE) ε4 allele on glucose metabolism and on the associations between glucose metabolism and age. ...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Knopman DS,Jack CR Jr,Wiste HJ,Lundt ES,Weigand SD,Vemuri P,Lowe VJ,Kantarci K,Gunter JL,Senjem ML,Mielke MM,Roberts RO,Boeve BF,Petersen RC

    更新日期:2014-09-01 00:00:00

  • Apolipoprotein E epsilon4 is associated with atrophy of the amygdala in Alzheimer's disease.

    abstract::Although the ApoE epsilon4 allele is well-established as the most important genetic risk factor for Alzheimer's disease (AD), the effects of this allele on regional brain atrophy in AD patients remain controversial. We performed MRI-based volumetric measurements of the hippocampus and amygdala (normalized to intracran...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Basso M,Gelernter J,Yang J,MacAvoy MG,Varma P,Bronen RA,van Dyck CH

    更新日期:2006-10-01 00:00:00