Abstract:
:Several signaling mechanisms that are crucial for the induction of long-term potentiation (LTP) by theta frequency (5 Hz) trains of synaptic stimulation are altered in aged animals. To determine whether theta frequency stimulation-induced LTP is particularly sensitive to changes in synaptic function that occur in aged animals, we examined whether activating synapses in the hippocampal CA1 region with three different trains of theta pulse stimulation (TPS) has different effects on synaptic strength in hippocampal slices from aged and young mice. Our results indicate that TPS-induced LTP is not diminished in the aged hippocampus but does show a dependence on L-type voltage-sensitive calcium channels that is not seen in young animals. Moreover, we found that the facilitation of TPS-induced LTP by co-activation of beta-adrenergic and cholinergic receptors is strongly reduced in slices from aged animals. Together, these results suggest that memory impairments in aged animals might arise, at least in part, from deficits in the ability of modulatory transmitters to regulate activity-dependent forms of synaptic plasticity.
journal_name
Neurobiol Agingjournal_title
Neurobiology of agingauthors
Watabe AM,O'Dell TJdoi
10.1016/s0197-4580(02)00082-9subject
Has Abstractpub_date
2003-03-01 00:00:00pages
267-72issue
2eissn
0197-4580issn
1558-1497pii
S0197458002000829journal_volume
24pub_type
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journal_title:Neurobiology of aging
pub_type: 杂志文章
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journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/j.neurobiolaging.2018.08.010
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journal_title:Neurobiology of aging
pub_type: 杂志文章
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journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/j.neurobiolaging.2014.03.006
更新日期:2014-09-01 00:00:00
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journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/j.neurobiolaging.2016.06.008
更新日期:2016-10-01 00:00:00
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journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/j.neurobiolaging.2005.07.020
更新日期:2006-09-01 00:00:00
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journal_title:Neurobiology of aging
pub_type: 杂志文章
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更新日期:2008-05-01 00:00:00
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journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/j.neurobiolaging.2013.08.005
更新日期:2014-02-01 00:00:00
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journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/j.neurobiolaging.2016.11.013
更新日期:2017-02-01 00:00:00
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journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/j.neurobiolaging.2008.07.014
更新日期:2010-06-01 00:00:00
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journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/j.neurobiolaging.2018.11.026
更新日期:2019-04-01 00:00:00
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journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/j.neurobiolaging.2006.09.016
更新日期:2008-02-01 00:00:00
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journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/j.neurobiolaging.2013.07.014
更新日期:2014-01-01 00:00:00
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journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/0197-4580(89)90087-0
更新日期:1989-09-01 00:00:00
abstract::Age-related structural brain changes have been demonstrated repeatedly but data on the effect of gender on age-related structural brain changes are conflicting. Using high-resolution T1-weighted magnetic resonance imaging and voxel-based morphometry, we examined a population of 133 healthy adults (women, 73; men, 60; ...
journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/j.neurobiolaging.2007.05.016
更新日期:2009-01-01 00:00:00
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journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/0197-4580(91)90091-w
更新日期:1991-09-01 00:00:00
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journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/j.neurobiolaging.2015.06.005
更新日期:2015-10-01 00:00:00
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journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/j.neurobiolaging.2015.12.019
更新日期:2016-04-01 00:00:00
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journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/0197-4580(91)90073-s
更新日期:1991-09-01 00:00:00
abstract::APOE-ε4 is a major genetic risk factor for late-onset Alzheimer's disease that interacts with other risk factors, but the nature of such combined effects remains poorly understood. We quantified the impact of APOE-ε4, family history (FH) of dementia, and obesity on white matter (WM) microstructure in 165 asymptomatic ...
journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/j.neurobiolaging.2020.06.014
更新日期:2020-10-01 00:00:00
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journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/j.neurobiolaging.2011.10.024
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abstract::In recent years, CHCHD2 and CHCHD10 mutations were reported to be associated with a broad spectrum of neurodegenerative diseases, including Parkinson's disease (PD), although with conflicting results in different populations. The present study aimed to evaluate CHCHD2 and CHCHD10 coding variants in Italian patients wi...
journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/j.neurobiolaging.2016.12.027
更新日期:2017-05-01 00:00:00
abstract::The first hypothesis free genome wide association study on cognition recently revealed the thus far unknown association of a single nucleotide polymorphism (SNP) of the KIBRA gene with episodic memory in healthy young and middle aged volunteers. Here, we report the first independent replication of this finding in an i...
journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/j.neurobiolaging.2007.02.001
更新日期:2008-07-01 00:00:00
abstract::Decreased levels of cerebrospinal fluid (CSF) Abeta42 is a diagnostic marker of Alzheimer's disease. To clarify the biological basis of this marker, the physiological alterations of CSF Abeta40 and Abeta42 by aging were studied. CSF samples from 92 normal subjects between 8 and 89 years old were measured using a speci...
journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/s0197-4580(00)00229-3
更新日期:2001-03-01 00:00:00
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journal_title:Neurobiology of aging
pub_type: 临床试验,杂志文章
doi:10.1016/j.neurobiolaging.2004.07.007
更新日期:2005-06-01 00:00:00
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journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/j.neurobiolaging.2019.03.017
更新日期:2019-07-01 00:00:00
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journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/0197-4580(90)90110-l
更新日期:1990-09-01 00:00:00
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journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/j.neurobiolaging.2016.02.028
更新日期:2016-06-01 00:00:00
abstract::Alzheimer's disease (AD) pathology has been described in Parkinson's disease (PD) patients with leucine-rich repeat kinase-2 (LRRK2) mutations. A common LRRK2 Gly2385Arg variant has been widely shown to be associated with a twofold increased risk of PD in various Asian populations. In a case control study, the frequen...
journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/j.neurobiolaging.2007.07.010
更新日期:2009-03-01 00:00:00
abstract::Although peripheral nerves are capable of regeneration, advanced age decreases the potential for functional recovery after injury. The cellular mechanisms for this are not currently understood. Here, we performed sciatic nerve grafting with young (2 months old) and aged (18 months old) Brown-Norway male rats, in which...
journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/j.neurobiolaging.2016.05.004
更新日期:2016-09-01 00:00:00