abstract：:A small litter (SL) model was used to determine how neonatal overfeeding affects the homeostatic control of food intake in male rats at weaning and postnatal day (PND) 90. At PND4, litters were reduced to small (4 pups/dam) or normal (10 pups/dam) litters. At weaning, SL rats showed higher body weight and characterist...

journal_title：Molecular and cellular endocrinology

authors： Schumacher R,Rossetti MF,Lazzarino GP,Canesini G,García AP,Stoker C,Andreoli MF,Ramos JG

更新日期：2021-02-15 00:00:00

abstract：:Mice carrying an RGS-insensitive Gαi2 mutation display growth retardation early after birth. Although the growth hormone (GH)-axis is a key endocrine modulator of postnatal growth, its functional state in these mice has not been characterized. The present study was undertaken to address this issue. Results revealed th...

journal_title：Molecular and cellular endocrinology

authors： Omouessi ST,Leipprandt JR,Akoume MY,Charbeneau R,Wade S,Neubig RR

更新日期：2021-02-05 00:00:00

abstract：:The final steps in the Renin-Angiotensin-Aldosterone signaling System (RAAS) involve binding of the corticosteroid hormone, aldosterone to its mineralocorticoid receptor (MR). The bound MR interacts with response elements to induce or repress the transcription of aldosterone-regulated genes. Along with the classic gen...

journal_title：Molecular and cellular endocrinology

authors： Butterworth MB

更新日期：2021-02-05 00:00:00

abstract：:Peritubular stem Leydig cells (SLCs) have been identified from rat testicular seminiferous tubules. However, no stem cells for peritubular myoid cells have been reported in the adult testis so far. In the present study, we tested the hypothesis that the peritubular SLCs are multipotent and able to form either Leydig o...

journal_title：Molecular and cellular endocrinology

authors： Zhao X,Wen X,Ji M,Guan X,Chen P,Hao X,Chen F,Hu Y,Duan P,Ge RS,Chen H

更新日期：2021-01-27 00:00:00

abstract：:Medullary thyroid carcinoma (MTC) is a rare neuroendocrine neoplasm of the parafollicular thyroid C cells. Although somatostatin receptors are expressed by MTCs, treatment with octreotide has shown poor efficacy, whereas recently pasireotide has demonstrated antiproliferative effects in persistent postoperative MTCs. ...

journal_title：Molecular and cellular endocrinology

authors： Giardino E,Catalano R,Mangili F,Barbieri AM,Treppiedi D,Elli FM,Dolci A,Contarino A,Spada A,Arosio M,Mantovani G,Peverelli E

更新日期：2021-01-15 00:00:00

abstract：:Glyphosate (Gly) is the herbicide widely used in agricultural fields and landscaping. Mammalian exposure to glyphosate could cause neurotoxicity, blood, liver, kidney, endocrine, reproductive, genetic and other toxic effects. Melatonin (MT) is a neuroendocrine hormone secreted mainly by the pineal gland. It is unknown...

journal_title：Molecular and cellular endocrinology

authors： Zhang J,Zhao C,Shi F,Zhang S,Wang S,Feng X

更新日期：2021-01-15 00:00:00

abstract：:Pituitary adenomas (PAs) hypersecrete hormones or cause mass effect symptoms, with 10%-35% patients showing resistance to standard therapies. Targeting epidermal growth factor receptor (EGFR) has significantly improved the clinical outcome in many cancers. In this study, immunochemistry results showed that EGFR associ...

journal_title：Molecular and cellular endocrinology

authors： Wei D,Yu Z,Cheng Y,Jiawei H,Jian G,Hua G,Guilan D

更新日期：2021-01-15 00:00:00

abstract：:Considering that post-menopausal women and ovariectomized rodents develop obesity associated with increased visceral fat, this study was developed to investigate if liraglutide, a glucagon-like peptide 1 (GLP1) analogue, could improve the metabolism of estrogen (E2) deficient females. Wistar rats were ovariectomized (...

journal_title：Molecular and cellular endocrinology

authors： Model JFA,Lima MV,Ohlweiler R,Lopes Vogt É,Rocha DS,Souza SK,Türck P,Araújo ASDR,Vinagre AS

更新日期：2021-01-11 00:00:00

abstract：:Growth hormone (GH) and its mediator, the insulin-like growth factor-1 (IGF-1) regulate somatic growth, metabolism and many aspects of aging. As such, actions of GH/IGF have been studied in many tissues and organs over decades. GH and IGF-1 are part of the hypothalamic/pituitary somatotrophic axis that consists of man...

journal_title：Molecular and cellular endocrinology

authors： Dixit M,Poudel SB,Yakar S

更新日期：2021-01-01 00:00:00

abstract：:This study investigated the effects of SOD2 (MnSOD)-deficiency-induced excessive oxidative stress on ovarian steroidogenesis in vivo and isolated and cultured granulosa cells using WT and Sod2+/- mice. Basal and 48 h eCG-stimulated plasma progesterone levels were decreased ~50% in female Sod2+/- mice, whereas plasma p...

journal_title：Molecular and cellular endocrinology

authors： Zaidi SK,Shen WJ,Cortez Y,Bittner S,Bittner A,Arshad S,Huang TT,Kraemer FB,Azhar S

更新日期：2021-01-01 00:00:00

abstract：:The adrenal cortex functions to produce steroid hormones necessary for life. To maintain its functional capacity throughout life, the adrenal cortex must be continually replenished and rapidly repaired following injury. Moreover, the adrenal responds to endocrine-mediated organismal needs, which are highly dynamic and...

journal_title：Molecular and cellular endocrinology

authors： Hammer GD,Basham KJ

更新日期：2021-01-01 00:00:00

abstract：:The concept of Developmental Origins of Health and Disease (DOHaD) states that exposure to malnutrition early in life increase the incidence of non-communicable chronic diseases throughout the lifespan. In this study, a reduction in serum testosterone and an increase in estrogen levels were shown in older rats born to...

journal_title：Molecular and cellular endocrinology

authors： Portela LM,Santos SA,Constantino FB,Camargo AC,Colombelli KT,Fioretto MN,Barquilha CN,Périco LL,Hiruma-Lima CA,Scarano WR,Zambrano E,Justulin LA

更新日期：2020-12-31 00:00:00

abstract：:Many agrochemicals have endocrine disrupting properties. A subset of these chemicals is characterized as "estrogenic". In this review, we describe several distinct ways that chemicals used in crop production can affect estrogen signaling. Using three agrochemicals as examples (DDT, endosulfan, and atrazine), we illust...

journal_title：Molecular and cellular endocrinology

authors： Vandenberg LN,Najmi A,Mogus JP

更新日期：2020-12-01 00:00:00

abstract：:Melatonin can be synthesized and secreted not only by the pineal gland but also by many extra-pineal tissues. It has been shown that many ovarian functions are regulated by melatonin locally. Ovarian hyperstimulation syndrome (OHSS) is a serious complication during ovulation induction of the in vitro fertilization tre...

journal_title：Molecular and cellular endocrinology

authors： Li Y,Fang L,Zhang R,Wang S,Li Y,Yan Y,Yu Y,Cheng JC,Sun YP

更新日期：2020-12-01 00:00:00

abstract：:Acid-labile subunit (ALS) deficiency (ACLSD) constitutes the first monogenic defect involving a member of the Insulin-like Growth Factor (IGF) binding protein system. The lack of ALS completely disrupts the circulating IGF system. Autocrine/paracrine action of local produced IGF-I could explain the mild effect on grow...

journal_title：Molecular and cellular endocrinology

authors： Domené S,Domené HM

更新日期：2020-12-01 00:00:00

abstract：:The type 1 diabetes (T1D) risk locus on chromosome 15q25.1 harbors the candidate gene CTSH (cathepsin H). We previously demonstrated that CTSH regulates β-cell function in vitro and in vivo. CTSH overexpression protected insulin-secreting INS-1 cells against cytokine-induced apoptosis. The purpose of the present study...

journal_title：Molecular and cellular endocrinology

authors： Fløyel T,Mirza AH,Kaur S,Frørup C,Yarani R,Størling J,Pociot F

更新日期：2020-12-01 00:00:00

abstract：:Lipotoxic injury of pancreatic β cells is an important pathological feature in type 2 diabetes mellitus (T2DM). Stimulator of interferon genes (STING) can recognize its own DNA leaked into the cytoplasm from damaged mitochondria or nuclei of the host cell, thus activating its downstream factor interferon regulatory fa...

journal_title：Molecular and cellular endocrinology

authors： Hu HQ,Qiao JT,Liu FQ,Wang JB,Sha S,He Q,Cui C,Song J,Zang N,Wang LS,Sun Z,Chen L,Hou XG

更新日期：2020-12-01 00:00:00

abstract：:Chronic restraint stress (CRS) magnifies restraint-induced corticosterone secretion through a mechanism involving increased adrenocortical 5-HT content and turnover. We analysed the impact of CRS on serotonin transporter (SERT) expression and distribution in rat adrenal glands. Male Wistar rats were submitted to CRS (...

journal_title：Molecular and cellular endocrinology

authors： Shanker S,Saroj N,Cordova EJ,Jarillo-Luna RA,López-Sánchez P,Terrón JA

更新日期：2020-12-01 00:00:00

abstract：:Hypogonadism is more frequent among men with common metabolic diseases, notably obesity and type 2 diabetes. Indeed, endocrine disruption caused by metabolic diseases can trigger the onset of hypogonadism, although the underlying molecular mechanisms are not entirely understood. Metabolic diseases are closely related ...

journal_title：Molecular and cellular endocrinology

authors： Crisóstomo L,Pereira SC,Monteiro MP,Raposo JF,Oliveira PF,Alves MG

更新日期：2020-10-01 00:00:00

abstract：:Obesity patients are more susceptible to develop COVID-19 severe outcome due to the role of angiotensin-converting enzyme 2 (ACE2) in the viral infection. ACE2 is regulated in the human cells by different genes associated with increased (TLR3, HAT1, HDAC2, KDM5B, SIRT1, RAB1A, FURIN and ADAM10) or decreased (TRIB3) vi...

journal_title：Molecular and cellular endocrinology

authors： de Oliveira M,De Sibio MT,Mathias LS,Rodrigues BM,Sakalem ME,Nogueira CR

更新日期：2020-09-15 00:00:00

abstract：:Hepatic nuclear factor 4 alpha (HNF4α) drives the expression of apolipoprotein B (ApoB), microsomal triglyceride transfer protein (MTP) and phospholipase A2 G12B (PLA2G12B), governing hepatic very-low-density lipoprotein (VLDL) production and secretion. Andrographolide (AP) is a major constituent isolated from Androgr...

journal_title：Molecular and cellular endocrinology

authors： Zhang M,Yang M,Wang N,Liu Q,Wang B,Huang T,Tong Y,Ming Y,Wong CW,Liu J,Yao D,Guan M

更新日期：2020-08-01 00:00:00

abstract：:Agrochemicals or pesticides are compounds widely used to prevent, destroy or mitigate pests such as insects, rodents, herbs and weeds. However, most of them also act as environmental estrogens, anti-estrogens and/or antiandrogenic chemicals. In addition, both herbicides (such as glyphosate and paraquat) and insecticid...

journal_title：Molecular and cellular endocrinology

authors： Rossetti MF,Stoker C,Ramos JG

更新日期：2020-06-15 00:00:00

abstract：:Local mediator prostaglandins and bradykinin are involved in inflammation and pain. We explored bradykinin effects on prostaglandin E2 (PGE2) release from fibroblasts derived from human skeletal muscular biopsies. Bradykinin induced PGE2 release through bradykinin B2 receptors, since PGE2 release was blocked by the br...

journal_title：Molecular and cellular endocrinology

authors： Muscella A,Cossa LG,Vetrugno C,Marsigliante S

更新日期：2020-05-01 00:00:00

abstract：:In euryhaline fishes, atrial and B-type natriuretic peptides are important hormones in hypo-osmoregulation, whereas osmoregulatory functions of C-type natriuretic peptides (CNPs) remain to be investigated. Although four CNP isoforms (CNP1-4) are mainly expressed in the brain, multiorgan expression of CNP3 was found in...

journal_title：Molecular and cellular endocrinology

authors： Katayama Y,Wong MK,Kusakabe M,Fujio M,Takahashi N,Yaguchi M,Tsukada T

更新日期：2020-05-01 00:00:00

abstract：:The aim of this study was to investigate whether co-culture of human islets with adipose-derived stem cells (ASCs) can improve islet quality and to evaluate which factors play a role in the protective effect of ASCs against islet dysfunction. Islets and ASCs were cultured in three experimental groups for 24 h, 48 h, a...

journal_title：Molecular and cellular endocrinology

authors： de Souza BM,Rodrigues M,de Oliveira FS,da Silva LPA,Bouças AP,Portinho CP,Dos Santos BP,Camassola M,Rocha D,Lysakowski S,Martini J,Leitão CB,Nardi NB,Bauer AC,Crispim D

更新日期：2020-04-05 00:00:00

abstract：:Microcirculation maintenance is associated with microRNAs. Nevertheless, the role of microRNAs induced by training in preventing dexamethasone (DEX)-induced microvascular rarefaction remains unknown. The study aim was to investigate if training-induced microRNAs are able to improve microcirculation proteins and preven...

journal_title：Molecular and cellular endocrinology

authors： Herrera NA,Duchatsch F,Tardelli LP,Dionísio TJ,Shinohara AL,Santos CF,Amaral SL

更新日期：2020-04-05 00:00:00

abstract：:Endocrine-disrupting chemicals (EDCs), such as perfluorooctanoate, perfluorooctane sulfonate, 2,2-dichlorodiphenyldichloroethylene, hexachlorobenzene, and polychlorinated biphenyl 153 are persistent pollutants that are found in human follicular fluid (FF). These compounds may affect endocrine function, disrupt steroid...

journal_title：Molecular and cellular endocrinology

authors： Gogola J,Hoffmann M,Nimpsz S,Ptak A

更新日期：2020-03-01 00:00:00

abstract：:Prenatal testosterone (T)-treated female sheep exhibit an enhanced inflammatory and oxidative stress state in the visceral adipose tissue (VAT) but not in the subcutaneous (SAT), while surprisingly maintaining insulin sensitivity in both depots. In adult sheep, adipose tissue is predominantly composed of white adipocy...

journal_title：Molecular and cellular endocrinology

authors： Puttabyatappa M,Ciarelli JN,Chatoff AG,Singer K,Padmanabhan V

更新日期：2020-03-01 00:00:00

abstract：:Endocrine disrupting chemicals are known to cause neurodevelopmental toxicity through direct and indirect pathways. In this study we used data from the National Health and Nutrition Examination Surveys, along with known exposure-disease relationships, to quantify the intellectual disability burden attributable to in u...

journal_title：Molecular and cellular endocrinology

authors： Gaylord A,Osborne G,Ghassabian A,Malits J,Attina T,Trasande L

更新日期：2020-02-15 00:00:00

abstract：:Successful embryo implantation is a complex and highly regulated process involving precise synchronization between the fetal-derived trophoblast cells and maternal uterine luminal epithelium. Multiple endocrine-driven factors are important for controlling the timely receptivity of the uterus, and this complexity under...

journal_title：Molecular and cellular endocrinology

authors： Quinn KE,Matson BC,Wetendorf M,Caron KM

更新日期：2020-02-05 00:00:00

abstract：:The beneficial effects of empagliflozin (EMPA) on cardiac functions during ischemia and reperfusion were characterized. The contractile functions of isolated cardiomyocytes from adult C57BL/6J mice were determined with IonOptix SoftEdgeMyoCam system. The mitochondrial superoxide production was measured by MitoSOX fluo...

journal_title：Molecular and cellular endocrinology

authors： Lu Q,Liu J,Li X,Sun X,Zhang J,Ren D,Tong N,Li J

更新日期：2020-02-05 00:00:00

abstract：:Polycystic Ovary Syndrome (PCOS) is the most common endocrine disorder amongst women of reproductive age, whose aetiology remains unclear. To improve our understanding of the molecular mechanisms underlying the disease, we conducted a genome-wide DNA methylation profiling in granulosa lutein cells collected from 16 wo...

journal_title：Molecular and cellular endocrinology

authors： Makrinou E,Drong AW,Christopoulos G,Lerner A,Chapa-Chorda I,Karaderi T,Lavery S,Hardy K,Lindgren CM,Franks S

更新日期：2020-01-15 00:00:00

abstract：:The reduction in muscle mass and strength with age, sarcopenia, is a prevalent condition among the elderly, linked to skeletal muscle dysfunction and cell apoptosis. We demonstrated that testosterone protects against H2O2-induced apoptosis in C2C12 muscle cells. Here, we analyzed the effect of testosterone on mitochon...

journal_title：Molecular and cellular endocrinology

authors： Pronsato L,Milanesi L,Vasconsuelo A

更新日期：2020-01-15 00:00:00

abstract：:Adrenocortical tumors (ACTs) frequently cause steroid excess and present cell-cycle dysregulation. cAMP/PKA signaling is involved in steroid synthesis and play a role in cell-cycle regulation. We investigated, by cell synchronization in the different phases of the cell-cycle, the control of steroidogenesis and the con...

journal_title：Molecular and cellular endocrinology

authors： Rizk-Rabin M,Chaoui-Ibadioune S,Vaczlavik A,Ribes C,Polak M,Ragazzon B,Bertherat J

更新日期：2020-01-15 00:00:00

abstract：BACKGROUND/PURPOSE:It remains unclear what role curcumin plays in the autophagy of osteoclast precursors (OCPs) during osteoclastogenesis, since some researchers found that curcumin has the ability to inhibit osteoclastogenesis. While others have considered it as an autophagy activator. This study aimed to determine th...

journal_title：Molecular and cellular endocrinology

authors： Ke D,Wang Y,Yu Y,Wang Y,Zheng W,Fu X,Han J,Zhang G,Xu J

更新日期：2020-01-15 00:00:00

abstract：:Secreted, plasma membrane, and resident proteins of the secretory pathway are synthesized in the endoplasmic reticulum (ER) where they undergo post-translational modifications, oxidative folding, and subunit assembly in tightly monitored processes. An ER quality control (ERQC) system oversees protein maturation and en...

journal_title：Molecular and cellular endocrinology

authors： Oikonomou C,Hendershot LM

更新日期：2020-01-15 00:00:00

abstract：:Although estradiol bone contribution has been deeply studied, little is known about the action of estrone. We investigated the direct action of estrone on osteoblasts growth and differentiation, with focus on the biochemical mechanism displayed by the estrogen. Murine calvarial osteoblast cultures in vitro exposed to ...

journal_title：Molecular and cellular endocrinology

authors： Crescitelli MC,Rauschemberger MB,Cepeda S,Sandoval M,Massheimer VL

更新日期：2019-12-01 00:00:00

abstract：:In this study, we determined whether estragole and its isomer trans-anethole interfered with feto-placental steroidogenesis in a human co-culture model composed of fetal-like adrenocortical (H295R) and placental trophoblast-like (BeWo) cells. Estragole and trans-anethole are considered the biologically active compound...

journal_title：Molecular and cellular endocrinology

authors： Yancu D,Vaillancourt C,Sanderson JT

更新日期：2019-12-01 00:00:00

abstract：:Eating disorders, namely anorexia nervosa, bulimia nervosa and binge eating disorder are frequent diseases and often complicated by comorbidities, e.g. psychiatric or cardiovascular comorbidities. It is to note that also gastrointestinal symptoms/complications are frequently observed in patients with eating disorders....

journal_title：Molecular and cellular endocrinology

authors： Hetterich L,Mack I,Giel KE,Zipfel S,Stengel A

更新日期：2019-11-01 00:00:00

abstract：:Some environmental contaminants and pharmaceuticals increase the incidence of uterine tumors in toxicological studies with rats. These tumors can result from a hormonal imbalance due to rat-specific disrupted pituitary prolactin regulation, and are therefore of questionable relevance for humans. In this study we compa...

journal_title：Molecular and cellular endocrinology

authors： van den Brand AD,Rubinstein E,van den Berg M,van Duursen MBM

更新日期：2019-10-01 00:00:00