An update on gastrointestinal disturbances in eating disorders.

abstract：:Different factors are involved in thyroid function and proliferation such as thyrotropin (TSH), insulin, growth factors, iodide, etc. TSH and IGF1/insulin increase proliferation rate and stimulate genes involved in thyroid differentiation. In the present study, we analyse the physiological regulation of NOX4 expressio...

journal_title：Molecular and cellular endocrinology

authors： Oglio R,Salvarredi L,Rossich L,Copelli S,Pisarev M,Juvenal G,Thomasz L

更新日期：2019-01-15 00:00:00

abstract：:The endocrine activity of 1,25-dihydroxyvitamin D (1,25(OH)(2)D(3)) contributes to maintaining plasma calcium and phosphate homeostasis through actions on the intestine, kidney and bone. A significant body of evidence has been published over the last 10 years indicating that all major bone cells have the capacity to m...

journal_title：Molecular and cellular endocrinology

authors： Anderson PH,Atkins GJ,Turner AG,Kogawa M,Findlay DM,Morris HA

更新日期：2011-12-05 00:00:00

abstract：:This study demonstrates that a single subcutaneous injection of gonadotrophin-releasing hormone (GnRH) (60 ng) to GnRH-deficient (hpg) male mice causes a doubling of pituitary GnRH receptors (GnRH-R). No change in GnRH-R occurs during the time of LH release (15-60 min) or up until 4 h post-GnRH. Between 4 and 12 h the...

journal_title：Molecular and cellular endocrinology

authors： Detta A,Naik SI,Charlton HM,Young LS,Clayton RN

更新日期：1984-09-01 00:00:00

abstract：:Delphinidin possesses the highest chemopreventive activity among the six components of anthocyanidin that are pigments from fruits and vegetables giving them blue, purple or red colors. Although delphinidin has anti-carcinogenic and apoptotic effects in various cancers, little is known about its functional roles in ov...

journal_title：Molecular and cellular endocrinology

authors： Lim W,Jeong W,Song G

更新日期：2016-02-15 00:00:00

abstract：:Thyroid dysgenesis is the most frequent cause of congenital hypothyroidism, but its molecular pathophysiology is largely unknown. Our hypothesis that some genes downstream to thyroid transcription factor-2 (TTF-2) might be responsible for development of the thyroid prompted us to identify genes whose expression is sti...

journal_title：Molecular and cellular endocrinology

authors： Hishinuma A,Ohmika N,Namatame T,Ieiri T

更新日期：2004-06-30 00:00:00

abstract：:The congenital adrenal hyperplasias (CAH) are a group of genetic defects in cortisol biosynthesis, most commonly steroid 21-hydroxylase deficiency (21OHD). With the advent of cortisone therapy in the 1960s and newborn screening in the 1990s, most children with 21OHD now reach adulthood. The needs and concerns of adult...

journal_title：Molecular and cellular endocrinology

authors： Auchus RJ

更新日期：2015-06-15 00:00:00

abstract：:The functional significance of two unlinked human vitamin D receptor (hVDR) gene polymorphisms was evaluated in twenty human fibroblast cell lines. Genotypes at both a Fok I restriction site (F/f) in exon II and a singlet (A) repeat in exon IX (L/S) were determined, and relative transcription activities of endogenous ...

journal_title：Molecular and cellular endocrinology

authors： Whitfield GK,Remus LS,Jurutka PW,Zitzer H,Oza AK,Dang HT,Haussler CA,Galligan MA,Thatcher ML,Encinas Dominguez C,Haussler MR

更新日期：2001-05-25 00:00:00

abstract：:Studies were performed to evaluate the relationships between the effects of angiotensin II on calcium metabolism and cytosolic free calcium concentration in primary monolayer cultures of bovine adrenal glomerulosa cells. As noted previously (Kramer (1988) Am. J. Physiol. (in press], angiotensin II produced rapid dose-...

journal_title：Molecular and cellular endocrinology

authors： Kramer RE

更新日期：1988-12-01 00:00:00

abstract：:Protein phosphorylation-dephosphorylation appears to be an essential component in the regulation of many cellular processes by hormones and drugs. This concept has developed primarily from in vitro biochemical studies in which various purified proteins have been phosphorylated and dephosphorylated by distinct protein ...

journal_title：Molecular and cellular endocrinology

authors： Manning DR,DiSalvo J,Stull JT

更新日期：1980-07-01 00:00:00

abstract：:Cultured rat anterior pituitary cells were continuously perfused with medium 199, and exposed to short (5 min), intermediate (30 min), or long (6 h) pulses of a maximally effective concentration of gonadotropin-releasing hormone (GnRH). Assay of the effluent by radioimmunoassay and interstitial-cell bioassay revealed ...

journal_title：Molecular and cellular endocrinology

authors： Naor Z,Katikineni M,Loumaye E,Vela AG,Dufau ML,Catt KJ

更新日期：1982-07-01 00:00:00

abstract：:During critical periods of development, hypothyroidism causes abnormalities of the central nervous system such as incomplete maturation of neuronal and glial cells, reduction in synaptic densities and myelin deficits. In this study expression of development regulated genes, ie transcription of beta-actin, sema 3F, CRM...

journal_title：Molecular and cellular endocrinology

authors： Wong CC,Leung MS

更新日期：2001-11-26 00:00:00

abstract：:Placental leptin secretion has important implications for maternal adaptation to pregnancy, fetal growth and development, and local autocrine/paracrine actions within trophoblast. In this study we used a cell culture insert model to examine directional secretion of leptin from the basal and apical surfaces of human ch...

journal_title：Molecular and cellular endocrinology

authors： Wyrwoll CS,Mark PJ,Waddell BJ

更新日期：2005-09-28 00:00:00

abstract：:Recent evidence suggests that the classic gut peptide, Peptide YY (PYY), could play a fundamental role in endocrine pancreatic function. In the present study expression of PYY and its NPY receptors on mouse islets and immortalised rodent and human beta-cells was examined together with the effects of both major circula...

journal_title：Molecular and cellular endocrinology

authors： Khan D,Vasu S,Moffett RC,Irwin N,Flatt PR

更新日期：2016-11-15 00:00:00

abstract：:Estrogens are synthesized from C19 steroids by a unique form of cytochrome P450, aromatase cytochrome P-450 (P-450AROM; the product of the CYP19 gene). We have shown that tissue-specific expression of human P-450AROM is determined, in part, by the use of alternative promoters. Previous methods of analysis for determin...

journal_title：Molecular and cellular endocrinology

authors： Jenkins C,Michael D,Mahendroo M,Simpson E

更新日期：1993-11-01 00:00:00

abstract：:Hypospadias is one of the most common congenital malformations. It is considered to be a mild form of the 46,XY disorders of sex development (DSD), but its precise etiology remains to be elucidated. Compromised androgen synthesis or effects can cause this frequent malformation, although the mutational analyses of the ...

journal_title：Molecular and cellular endocrinology

authors： Kalfa N,Philibert P,Baskin LS,Sultan C

更新日期：2011-03-30 00:00:00

abstract：:The expression of the gene coding for thyroperoxydase, the main enzyme involved in the synthesis of the thyroid hormones, is controlled by thyroid stimulating hormone. In vitro transcription assays performed on nuclei isolated from dog thyroid cells in primary culture showed that this control is at the transcription l...

journal_title：Molecular and cellular endocrinology

authors： Gerard CM,Lefort A,Libert F,Christophe D,Dumont JE,Vassart G

更新日期：1988-12-01 00:00:00

abstract：:The effects of the preovulatory luteinizing hormone (LH) surge on the ovulatory process are mediated by prostaglandins (PGs), the synthesis of which involves prostaglandin synthetase and cytosolic phospholipase A2 (cPLA2). In our previous study, we systematically investigated the function of prostaglandin endoperoxide...

journal_title：Molecular and cellular endocrinology

authors： Tang H,Wang L,Chen Y,He J,Qu L,Guo Y,Liu Y,Liu X,Lin H

更新日期：2018-09-15 00:00:00

abstract：:[3-H]Melatonin administered in vivo in the rat cisterna magna became associated with a vinblastine-precipitable protein. Melatonin treatment decreased microtubule protein content by 44% in the arcuate-median eminence region and by 19% in the remaining hypothalamic block, being without significant effect on the cerebra...

journal_title：Molecular and cellular endocrinology

authors： Cardinali DP,Freire F

更新日期：1975-05-01 00:00:00

abstract：:The inappropriate expressions of insulin-like growth factors (IGF-I and II) and IGF-I receptor (IGF-IR) are implicated in the malignant growth of many cancers. To determine changes, if any, in the levels of expression of IGFs and IGF receptor genes in neoplastic endometrium, relative to normal endometrium, the mRNA le...

journal_title：Molecular and cellular endocrinology

authors： Roy RN,Gerulath AH,Cecutti A,Bhavnani BR

更新日期：1999-07-20 00:00:00

abstract：:Somatostatin has been discovered as a somatotroph release inhibitory factor (SRIF), and, indeed, it has been demonstrated that SRIF and its analogs can inhibit pituitary tumor hormone secretion and control neoplastic bulk. Several in vitro studies have contributed to the current knowledge of the mechanisms by which SR...

journal_title：Molecular and cellular endocrinology

authors： Zatelli MC,Ambrosio MR,Bondanelli M,degli Uberti EC

更新日期：2008-05-14 00:00:00

abstract：:All mammalian cells rely on adenosine triphosphate (ATP) to maintain function and for survival. The heart has the highest basal ATP demand of any organ due to the necessity for continuous contraction. As such, the ability of the cardiomyocyte to monitor cellular energy status and adapt the supply of substrates to matc...

journal_title：Molecular and cellular endocrinology

authors： Nagendran J,Waller TJ,Dyck JR

更新日期：2013-02-25 00:00:00

abstract：:Environmental conditions in early life permanently alter the development of glucocorticoid receptor gene expression in the hippocampus and hypothalamic-pituitary-adrenal responses to acute or chronic stress. In part, these effects can involve an activation of ascending serotonergic pathways and subsequent changes in t...

journal_title：Molecular and cellular endocrinology

authors： Weaver IC,La Plante P,Weaver S,Parent A,Sharma S,Diorio J,Chapman KE,Seckl JR,Szyf M,Meaney MJ

更新日期：2001-12-20 00:00:00

abstract：:C-fos promoter activity was examined in FRTL5 rat thyroid cells transiently transfected with a chimeric gene containing the c-fos promoter region linked upstream of the receptor gene chloroamphenicol acetyl transferase (CAT). Thyroid-stimulating hormone (TSH) stimulation of transfected cells increased CAT activity 2- ...

journal_title：Molecular and cellular endocrinology

authors： Damante G,Rapoport B

更新日期：1988-08-01 00:00:00

abstract：:The recent growth of interest in developmental programming of physiological systems has generally focused on the cardiovascular system (especially hypertension) and predisposition to metabolic dysfunction (mainly obesity and diabetes). However, it is now clear that the full range of altered offspring phenotypes includ...

journal_title：Molecular and cellular endocrinology

authors： Zambrano E,Guzmán C,Rodríguez-González GL,Durand-Carbajal M,Nathanielsz PW

更新日期：2014-01-25 00:00:00

abstract：:Within the seminiferous tubules, the Sertoli cells create an impermeable blood-testis barrier and an unique intratubular microenvironment that fosters the development of spermatozoa. The functional differentiation of spermatozoa therefore requires vectorial secretion by Sertoli cells of substances that cannot cross th...

journal_title：Molecular and cellular endocrinology

authors： Spaliviero JA,Handelsman DJ

更新日期：1991-10-01 00:00:00

abstract：:Increasing evidence in recent years has demonstrated the regulatory effects of arachidonic acid and its metabolites on steroid hormone production in various steroidogenic tissues. In trophic hormone-stimulated steroidogenesis, arachidonic acid is rapidly released from phospholipids. This release is dependent upon horm...

journal_title：Molecular and cellular endocrinology

authors： Wang X,Stocco DM

更新日期：1999-12-20 00:00:00

abstract：:It has been well established for decades that androgens, namely testosterone (T) plays an important role in female reproductive physiology as the precursor for oestradiol (E2). However, in the last decade a direct role for androgens, acting via the androgen receptor (AR), in female reproductive function has been confi...

journal_title：Molecular and cellular endocrinology

authors： Walters KA,Handelsman DJ

更新日期：2018-04-15 00:00:00

abstract：:Although well-established, the underlying mechanisms involved in obesity-related plasma adiponectin decline remain elusive. Oxidative stress is associated with obesity and insulin resistance and considered to contribute to the progression toward obesity-related metabolic disorders. In this study, we investigated the e...

journal_title：Molecular and cellular endocrinology

authors： Wang Z,Dou X,Gu D,Shen C,Yao T,Nguyen V,Braunschweig C,Song Z

更新日期：2012-02-26 00:00:00

abstract：:The 11 beta-hydroxysteroid dehydrogenase type II enzyme (11 beta HSD2) converts cortisol into mineralocorticoid receptor inactive cortisone, thus preventing occupation of the non-selective mineralocorticoid receptor by glucocorticoids in the kidney. Mutations generating inactive enzymes have been described in the HSD1...

journal_title：Molecular and cellular endocrinology

authors： Ferrari P,Obeyesekere VR,Li K,Wilson RC,New MI,Funder JW,Krozowski ZS

更新日期：1996-05-17 00:00:00

abstract：:Vitelline membrane outer layer protein 1 (VMO1), a basic protein present in the outer layer of the vitelline membrane of eggs, plays essential roles in separating the yolk from the egg white and preventing infection from bacteria by forming a barrier of fibrous layers in avian eggs. Although VMO1 is expressed in the o...

journal_title：Molecular and cellular endocrinology

authors： Lim W,Song G

更新日期：2015-01-05 00:00:00