Hypospadias: interactions between environment and genetics.

abstract：:The stimulatory effects on Leydig cell testosterone secretion of a polypeptide(s) factor present in testicular interstitial fluid (IF) were compared with those of hCG and an LHRH agonist (LHRH-A). The actions of IF and LHRH-A were similar in showing (1) a delayed onset of action, (2) enhancement of testosterone produc...

journal_title：Molecular and cellular endocrinology

authors： Sharpe RM

更新日期：1985-07-01 00:00:00

abstract：:Human chorionic gonadotropin (hCG) is synthesized primarily in the placenta while human luteinizing hormone (hLH) is produced in the pituitary. Both hormones are highly homologous in structure and both appear to be altered to analogous molecular forms as the hormones are proteolytically processed, or metabolized, from...

journal_title：Molecular and cellular endocrinology

authors： Birken S,Kovalevskaya G,O'Connor J

更新日期：1996-12-20 00:00:00

abstract：:We have established granulosa cell lines which express constitutively the rat FSH receptors by cotransfection of primary granulosa cells obtained from preovulatory follicles with SV40 DNA, Ha-ras oncogene and a plasmid expressing FSH receptors. These cells respond specifically to ovine and human FSH by cell rounding, ...

journal_title：Molecular and cellular endocrinology

authors： Schiffer Z,Keren-Tal I,Deutsch M,Dantes A,Aharoni D,Weinerb A,Tirosh R,Amsterdam A

更新日期：1996-04-19 00:00:00

abstract：:Inhibin is a member of the TGF-beta superfamily of growth and differentiation factors and a tumor suppressor. Consistent with the tumor suppressive function of the inhibin alpha subunit in prostate cancer, we reported a loss of gene expression due to DNA hypermethylation and loss of heterozygosity (LOH) as well as dow...

journal_title：Molecular and cellular endocrinology

authors： Risbridger GP,Ball EM,Wang H,Mellor SL,Peehl DM

更新日期：2004-10-15 00:00:00

abstract：:Desethylamiodarone (DEA), the major metabolite of the potent antiarrythmic drug amiodarone, is a non-competitive inhibitor of the binding of thyroid hormone (T3) to the beta 1-thyroid hormone receptor (T3R). In the present study, we investigated whether DEA acts in a similar way with respect to the alpha 1-T3R. The ch...

journal_title：Molecular and cellular endocrinology

authors： van Beeren HC,Bakker O,Wiersinga WM

更新日期：1995-07-01 00:00:00

abstract：:Calcium salts were found to replace ACTH in inducing steroidogenesis in isolated adrenocortical cells from rats. This Ca-specific stimulation occurred when the cation was presented to the cells in the presence of phosphate and carbonate as a counter-ions under conditions which favoured the formation of colloidal calci...

journal_title：Molecular and cellular endocrinology

authors： Neher R,Milani A

更新日期：1978-01-01 00:00:00

abstract：:The mouse mammary tumor virus (MMTV) initiates infection when the envelope protein, gp52, binds to a cell surface protein and triggers internalization. The hormonal regulation of this protein was studied both in vitro and in vivo. In mammary gland explant culture, levels of the MMTV binding protein were maintained onl...

journal_title：Molecular and cellular endocrinology

authors： Bolander FF Jr

更新日期：1991-12-01 00:00:00

abstract：:cAMP signalling plays a key role in the normal physiology of the pituitary gland, regulating cellular growth and proliferation, hormone production and release. Deregulation of the cAMP signalling pathway has been reported to be a common occurrence in pituitary tumorigenesis. Several mechanisms have been implicated inc...

journal_title：Molecular and cellular endocrinology

authors： Formosa R,Vassallo J

更新日期：2014-07-05 00:00:00

abstract：:Allatostatins, peptides with an YXFGL-amide C-terminus, cause a rapid and reversible inhibition of the sesquiterpenoid juvenile hormone III biosynthesis by cockroach corpora allata in vitro. Inhibition is relieved by farnesol and by mevalonate, and neither HMG-CoA reductase nor HMG-CoA synthesis (HMG-CoA synthase and ...

journal_title：Molecular and cellular endocrinology

authors： Sutherland TD,Feyereisen R

更新日期：1996-07-01 00:00:00

abstract：:Renal hypertrophy and hyperfiltration are early manifestations of human and experimental diabetes that may contribute to the late development of diabetic nephropathy. The biochemical events resulting in kidney growth in the diabetic state are completely unknown. Since growth of various tissues is accompanied by increa...

journal_title：Molecular and cellular endocrinology

authors： Pedersen SB,Flyvbjerg A,Grønbaek H,Richelsen B

更新日期：1992-07-01 00:00:00

abstract：:Thyrotropin-releasing hormone (TRH) stimulates maximally both the release of previously synthesized prolactin and the de novo synthesis of prolactin by GH4C1 rat pituitary cells at concentrations less than those necessary to fully occupy the TRH receptor at equilibrium. We have examined the dependency of maximal TRH-e...

journal_title：Molecular and cellular endocrinology

authors： Ramsdell JS,Tashjian AH Jr

更新日期：1985-12-01 00:00:00

abstract：:Gonadotrophins are fundamental to the mechanisms regulating follicle status and development. Follicles in the ovary are either quiescent or committed to one of two pathways: growth or atresia. The requirement for gonadotrophins by the follicles varies with development: committed follicles grow independently of gonadot...

journal_title：Molecular and cellular endocrinology

authors： Drummond AE,Findlay JK

更新日期：1999-05-25 00:00:00

abstract：:Recent findings demonstrated that a subset of papillary thyroid cancers (PTCs) is characterized by reduced expression of the von Hippel-Lindau (VHL) tumor suppressor gene, and that lowest levels associated with more aggressive PTCs. In the present study, the levels of the two VHL mRNA splicing variants, VHL-213 (V1) a...

journal_title：Molecular and cellular endocrinology

authors： Baldini E,Tuccilli C,Arlot-Bonnemains Y,Chesnel F,Sorrenti S,De Vito C,Catania A,D'Armiento E,Antonelli A,Fallahi P,Watutantrige-Fernando S,Tartaglia F,Barollo S,Mian C,Bononi M,Arceri S,Mascagni D,Vergine M,Pironi D

更新日期：2017-03-05 00:00:00

abstract：:Glucocorticoids play a major role in attenuation of the inflammatory response. These steroid hormones are able to induce apoptosis in cells of the hematopoietic system such as monocytes, macrophages and T-lymphocytes that are involved in the inflammation reaction. In contrast, it was discovered recently that in glandu...

journal_title：Molecular and cellular endocrinology

authors： Amsterdam A,Sasson R

更新日期：2002-03-28 00:00:00

abstract：:The growth of ZR-75-1 cells, a line of human breast cancer cells in culture, is stimulated by oestradiol and inhibited by anti-oestrogens. Changes in growth rate caused by these agents are accompanied by changes in activity of ornithine decarboxylase, a rate-limiting enzyme for polyamine synthesis. Furthermore, the gr...

journal_title：Molecular and cellular endocrinology

authors： Hoggard N,Green CD

更新日期：1986-06-01 00:00:00

abstract：:The inappropriate expressions of insulin-like growth factors (IGF-I and II) and IGF-I receptor (IGF-IR) are implicated in the malignant growth of many cancers. To determine changes, if any, in the levels of expression of IGFs and IGF receptor genes in neoplastic endometrium, relative to normal endometrium, the mRNA le...

journal_title：Molecular and cellular endocrinology

authors： Roy RN,Gerulath AH,Cecutti A,Bhavnani BR

更新日期：1999-07-20 00:00:00

abstract：:The aim of our study was to investigate the direct effects of atypical antipsychotics on muscle cell functions in order to ascertain the diabetic liability of these drugs. We investigated the effects of olanzapine, clozapine and alpha-methyl-5-hydroxytryptamine on basal glucose uptake and glucose uptake in response to...

journal_title：Molecular and cellular endocrinology

authors： Tulipano G,Spano P,Cocchi D

更新日期：2008-09-24 00:00:00

abstract：:Secretogranin I (SgI; chromogranin B) belongs to a class of acidic tyrosine-sulfated secretory proteins believed to play a role in the secretory process of endocrine cells. Our aim here was to compare the levels of SgI mRNA to that of prolactin (PRL) and growth hormone (GH), using rat pituitary cell lines. As far as t...

journal_title：Molecular and cellular endocrinology

authors： Laverrière JN,Richard JL,Morin A,Buisson N,Tixier-Vidal A,Huttner WB,Gourdji D

更新日期：1991-09-01 00:00:00

abstract：:The expression of the three genes encoding the components C1, C2 and C3 of prostatic binding protein (PBP) is under androgen control and restricted to the rat ventral prostate. The SstI-PvuII fragment of the first intron of the C3(1) gene displays two binding sites for ubiquitous transcription factors and one for a ti...

journal_title：Molecular and cellular endocrinology

authors： Celis L,Claessens F,Peeters B,Heyns W,Verhoeven G,Rombauts W

更新日期：1993-08-01 00:00:00

abstract：:Calcium is a second messenger responsible for regulating a wide range of cellular processes. It is normally presented as brief spikes even in non-excitable cells. The necessity of limiting the period of calcium stimulation to brief bursts may depend upon the fact that prolonged elevation of calcium can be toxic. It ca...

journal_title：Molecular and cellular endocrinology

authors： Berridge MJ

更新日期：1994-01-01 00:00:00

abstract：:Studies were performed to evaluate the relationships between the effects of angiotensin II on calcium metabolism and cytosolic free calcium concentration in primary monolayer cultures of bovine adrenal glomerulosa cells. As noted previously (Kramer (1988) Am. J. Physiol. (in press], angiotensin II produced rapid dose-...

journal_title：Molecular and cellular endocrinology

authors： Kramer RE

更新日期：1988-12-01 00:00:00

abstract：:The primary aim of this study was to evaluate the effects of arachidonic acid (AA) on calcium mobilization from intracellular compartments in digitonin-permeabilized granulosa cells isolated from the largest preovulatory follicles of laying hens. At low concentrations (ED50 0.2 microM) AA released 35% 45Ca from the en...

journal_title：Molecular and cellular endocrinology

authors： Hertelendy F,Molnár M,Jamaluddin M

更新日期：1992-02-01 00:00:00

abstract：:Adult neurogenesis occurs in neural stem cell (NSC) niches where slow cycling stem cells give rise to faster cycling progenitors. In the adult mouse NSC niche thyroid hormone, T3, and its receptor TRα act as a neurogenic switch promoting progenitor cell cycle completion and neuronal differentiation. Little is known ab...

journal_title：Molecular and cellular endocrinology

authors： Préau L,Le Blay K,Saint Paul E,Morvan-Dubois G,Demeneix BA

更新日期：2016-01-15 00:00:00

abstract：:Compromise of gastric inhibitory polypeptide (GIP) receptor signalling represents a possible therapeutic strategy for the treatment of obesity-related diabetes. This study has characterised and evaluated the C-terminally fatty acid derivatised GIP analogues, GIP(3-30)Cex-K(40)[Pal] and Pro(3)GIP(3-30)Cex-K(40)[Pal], a...

journal_title：Molecular and cellular endocrinology

authors： Pathak V,Gault VA,Flatt PR,Irwin N

更新日期：2015-02-05 00:00:00

abstract：:A rapid and sensitive assay of iodothyronine-5'-monodeiodinase (5'-D) was developed using Sephadex column chromatography for separation of substrate 125I-rT3 from the product free 125I-. The distribution of 5'-D activity on rat kidney cortex cell membranes was examined in isopycnic zonal centrifugation experiments usi...

journal_title：Molecular and cellular endocrinology

authors： Boye N,Laurberg P,Jørgensen PL

更新日期：1988-03-01 00:00:00

abstract：:Signaling pathways initiated by transforming growth factor-β (TGF-β) and insulin-like growth factors (IGFs) are important in osteosarcoma cell growth. We have investigated a role for endogenous IGF binding protein-3 (IGFBP-3) in mediating cross-talk between TGF-β receptor and type I IGF receptor (IGF1R) signaling path...

journal_title：Molecular and cellular endocrinology

authors： Schedlich LJ,Yenson VM,Baxter RC

更新日期：2013-09-05 00:00:00

abstract：:The present work describes the identification of (anti)progestin endocrine disrupting chemicals (EDC) using a two step screening system. In the first step a competitive binding assay was developed using recombinant human progesterone receptor (hPR). The tested chemicals were of various classes like insecticides, their...

journal_title：Molecular and cellular endocrinology

authors： Viswanath G,Halder S,Divya G,Majumder CB,Roy P

更新日期：2008-11-25 00:00:00

abstract：:Iodide Organification defects (IOD) represent 10% of cases of congenital hypothyroidism (CH) being the main genes affected that of TPO (thyroid peroxidase) and DUOX2 (dual oxidasa 2). From a patient with clinical and biochemical criteria suggestive with CH associated with IOD, TPO and DUOX2 genes were analyzed by mean...

journal_title：Molecular and cellular endocrinology

authors： Belforte FS,Citterio CE,Testa G,Olcese MC,Sobrero G,Miras MB,Targovnik HM,Rivolta CM

更新日期：2016-01-05 00:00:00

abstract：:mRNA differential display polymerase chain reaction analysis was used to screen systematically for novel androgen-regulated genes in the human prostatic adenocarcinoma cell line LNCaP. A 232 bp PCR fragment was found to be consistently down-regulated by the synthetic androgen R1881. Sequencing revealed complete identi...

journal_title：Molecular and cellular endocrinology

authors： Ulrix W,Swinnen JV,Heyns W,Verhoeven G

更新日期：1999-09-10 00:00:00

abstract：:The functions of anterior pituitary cells are controlled by two major groups of hypothalamic and intrapituitary ligands: one exclusively acts on G protein-coupled receptors and the other activates both G protein-coupled receptors and ligand-gated receptor channels. The second group of ligands operates as neurotransmit...

journal_title：Molecular and cellular endocrinology

authors： Zemková H,Stojilkovic SS

更新日期：2018-03-05 00:00:00