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Proteins interacting with an androgen-responsive unit in the C3(1) gene intron.

Abstract：

:The expression of the three genes encoding the components C1, C2 and C3 of prostatic binding protein (PBP) is under androgen control and restricted to the rat ventral prostate. The SstI-PvuII fragment of the first intron of the C3(1) gene displays two binding sites for ubiquitous transcription factors and one for a tissue-specific factor in a 80-bp region upstream of its androgen response element (ARE). The octamer transcription factor 1 (OTF-1) binds to the most distal element (site 1) while a member of the nuclear factor I (NF-I) family recognizes site 2. A third unidentified prostate-specific factor, which also occurs in castrated rats, interacts with the proximal element (site 3). In T-47D cells, both the OTF-1 and the NF-I-like factor can modulate the androgen response of the promoter in a reporter gene construct containing the C3(1) intronic fragment.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Celis L,Claessens F,Peeters B,Heyns W,Verhoeven G,Rombauts W

doi

10.1016/0303-7207(93)90165-g

subject

Has Abstract

pub_date

1993-08-01 00:00:00

pages

165-72

issue

2

eissn

0303-7207

issn

1872-8057

pii

0303-7207(93)90165-G

journal_volume

94

pub_type

杂志文章

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