Gene expression profiling in hearts of diabetic mice uncovers a potential role of estrogen-related receptor γ in diabetic cardiomyopathy.

abstract：:The number of pituitary cells, their size, hormonal content and release and response to external cues varies between day and night and during the estrus cycle. Previous studies have demonstrated that pituitary cells proliferate rhythmically and that estradiol (E(2)) is a mitogen of alpha T3 cells. We, therefore, studi...

journal_title：Molecular and cellular endocrinology

authors： Lewy H,Ashkenazi IE,Naor Z

更新日期：2003-05-30 00:00:00

abstract：:We have investigated protein kinase C (PKC) regulation by 1,25-(OH)2D3 in the rat osteosarcoma cell line ROS 17/2.8 since previous reports have implicated PKC in the 1,25-(OH)2D3-mediated regulation of osteocalcin gene expression (J. Biol. Chem. 267 (1992) 12562; Endocrinology 136 (1995) 5685). Here we report that 1,2...

journal_title：Molecular and cellular endocrinology

authors： Rivera-Bermúdez MA,Bertics PJ,Albrecht RM,Mosavin R,Mellon WS

更新日期：2002-02-25 00:00:00

abstract：:Porcine Leydig cells in primary culture were incubated to equilibrium with increasing doses of either porcine luteinizing hormone (pLH) or human chorionic gonadotropin (hCG). Then, free and total high affinity gonadotropin receptors on the cell surface were dosed with [125I]hCG as tracer. In isotonic high salt medium,...

journal_title：Molecular and cellular endocrinology

authors： Genty N,Salesse R,Jallal B,Garnier J

更新日期：1991-04-01 00:00:00

abstract：:Osteogenic activities of activin, a member of TGF-beta superfamily, have been shown in both in vivo and in vitro studies. Local injection of activin promoted fracture healing in rat fibula fracture models. Since both activin and its receptor are expressed during fracture healing, activin would be involved in the heali...

journal_title：Molecular and cellular endocrinology

authors： Sakai R,Eto Y

更新日期：2001-06-30 00:00:00

abstract：:This paper reviews work on progesterone and the progesterone receptor (PR) in the mouse mammary gland that has been used extensively as an experimental model. Studies have led to the concept that progesterone controls proliferation and morphogenesis of the luminal epithelium in a tightly orchestrated manner at distinc...

journal_title：Molecular and cellular endocrinology

authors： Obr AE,Edwards DP

更新日期：2012-06-24 00:00:00

abstract：:Lymphocyte cell lines were established from five patients with vitamin D-dependent rickets, type II (VDDR-II). These lines were established by infection with human T-lymphotrophic virus type I (HTLV-I). Binding of [3H]1 alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) to its receptor in these cell lines was compared to bind...

journal_title：Molecular and cellular endocrinology

authors： Koeffler HP,Bishop JE,Reichel H,Singer F,Nagler A,Tobler A,Walka M,Norman AW

更新日期：1990-03-26 00:00:00

abstract：:Cytochrome b(5) (cyt-b(5)) is essential for the regulation of steroidogenesis and as such has been implicated in a number of clinical conditions. It is well documented that this small hemoprotein augments the 17,20-lyase activity of cytochrome P450 17α-hydroxylase/17,20-lyase (CYP17A1). Studies have revealed that this...

journal_title：Molecular and cellular endocrinology

authors： Storbeck KH,Swart AC,Goosen P,Swart P

更新日期：2013-05-22 00:00:00

abstract：:Relaxin (RLX) is an insulin-like polypeptide hormone that was initially introduced for its pregnancy-related function. Subsequent studies revealed that RLX possesses anti-fibrotic functions in tumors and nonreproductive tissues, such as skin, lungs, and others. This aspect of the RLX has been explored for the treatmen...

journal_title：Molecular and cellular endocrinology

authors： Hong J,Yun CO

更新日期：2019-05-01 00:00:00

abstract：:The effects of chicken growth hormone (cGH) infusion on insulin-like growth factor (IGF-I) gene expression in rapidly-growing, meat-type chickens was investigated. Chicken GH was infused either continuously or in a pulsatile fashion to 8-week-old birds during a 7-day period. Following cGH infusion, both IGF-I peptide ...

journal_title：Molecular and cellular endocrinology

authors： Rosselot G,McMurtry JP,Vasilatos-Younken R,Czerwinski S

更新日期：1995-10-30 00:00:00

abstract：:We have previously shown that the tyrosine kinase receptor Flk-1 and its ligand, vascular endothelial growth factor (VEGF), may play a role in the development of fetal rat islet-like structures in vitro, possibly by stimulating the maturation of endocrine precursor cells in the pancreatic ductal epithelium. In order t...

journal_title：Molecular and cellular endocrinology

authors： Oberg-Welsh C,Sandler S,Andersson A,Welsh M

更新日期：1997-02-07 00:00:00

abstract：:Fibroblast growth factor (FGF)-21 is an endocrine member of the FGF family with healthy effects on glucose and lipid metabolism. FGF21 reduces glycemia and lipidemia in rodent models of obesity and type 2 diabetes. In addition to its effects improving insulin sensitivity, FGF21 causes weight loss by increasing energy ...

journal_title：Molecular and cellular endocrinology

authors： Giralt M,Gavaldà-Navarro A,Villarroya F

更新日期：2015-12-15 00:00:00

abstract：:We have localized four transcription initiation sites in the human insulin-like growth factor-I (IGF-I) gene. Two transcription start sites were identified which result in a longer and shorter version of the leader derived from the known exon 1 of the IGF-I gene. Transcription starting at the upstream transcription in...

journal_title：Molecular and cellular endocrinology

authors： Jansen E,Steenbergh PH,LeRoith D,Roberts CT Jr,Sussenbach JS

更新日期：1991-06-01 00:00:00

abstract：:One of the key messages of recent Salpea and Stratakis work is to underline the clinical similarities shared by these syndromes that could be explained by a defect in the same signaling pathway, i.e. activation of the cAMP pathway. That being said, we would like to emphasize that hepatopancreato-biliary lesions are on...

journal_title：Molecular and cellular endocrinology

authors： Gaujoux S,Chanson P,Bertherat J,Sauvanet A,Ruszniewski P

更新日期：2014-01-25 00:00:00

abstract：:Galectin-1 is highly expressed in blastocysts and trophoblast giant cells during implantation, and dysregulated galectin-1 is associated with many pregnancy-related abnormalities. Elevated galectin-1 contributes to cancer cells invasion. Here, we found that galectin-1 is expressed in mouse oocytes, preimplantation emb...

journal_title：Molecular and cellular endocrinology

authors： You JL,Wang W,Tang MY,Ye YH,Liu AX,Zhu YM

更新日期：2018-07-15 00:00:00

abstract：:Steroidogenic activity in the mature corpus luteum of most mammals depends upon provision of cholesterol from the circulating lipoproteins. In cattle, as in many species, high-density lipoprotein (HDL) is the major lipoprotein involved. The recent identification of the scavenger receptor SR-BI as an HDL-receptor allow...

journal_title：Molecular and cellular endocrinology

authors： Rajapaksha WR,McBride M,Robertson L,O'Shaughnessy PJ

更新日期：1997-10-31 00:00:00

abstract：:The aim of this study was to investigate whether short-term treatment with nitric oxide donors could mimic cytokine inhibition of insulin secretion. We tested the nitric oxide generating compounds 3-morpholinosydnonimine (SIN-1), S-nitroso-N-penicillamine (SNAP), S-nitrosoglutathione and hydroxylamine for their abilit...

journal_title：Molecular and cellular endocrinology

authors： Cunningham JM,Mabley JG,Delaney CA,Green IC

更新日期：1994-06-01 00:00:00

abstract：:The time- and dose-dependent effects of bovine activin A and bovine follicle stimulating hormone (FSH) suppressing protein (FSP) or follistatin on basal and FSH-induced steroidogenesis and inhibin production were studied in granulosa cells from immature, diethylstilbestrol (DES)-treated rats. In the presence of rat FS...

journal_title：Molecular and cellular endocrinology

authors： Xiao S,Findlay JK,Robertson DM

更新日期：1990-02-12 00:00:00

abstract：:Glomerulosa cells secrete aldosterone in response to agonists coupled to Ca(2+) increases such as angiotensin II and corticotrophin, coupled to a cAMP dependent pathway. A recently recognized interaction between Ca(2+) and cAMP is the Ca(2+)-induced cAMP formation in the mitochondrial matrix. Here we describe that sol...

journal_title：Molecular and cellular endocrinology

authors： Katona D,Rajki A,Di Benedetto G,Pozzan T,Spät A

更新日期：2015-09-05 00:00:00

abstract：:Sex hormone-binding globulin (SHBG) is the main transport binding protein for sex steroid hormones in plasma and regulates their accessibility to target cells. Plasma SHBG is secreted by the liver under the control of hormones and nutritional factors. In the human hepatoma cell line (HepG2), thyroid and estrogenic hor...

journal_title：Molecular and cellular endocrinology

authors： Pugeat M,Nader N,Hogeveen K,Raverot G,Déchaud H,Grenot C

更新日期：2010-03-05 00:00:00

abstract：:Transgenic mice carrying a fused gene of the 294-base upstream and 68-base leader sequences of a rat calmodulin gene, CaMII, and beta-galactosidase gene were made. Only spermatocytes expressed the transgene mRNA in the testes of four independent transgenic lines. The localization of transgene mRNA was consistent with ...

journal_title：Molecular and cellular endocrinology

authors： Ikeshima H,Shimoda K,Matsuo K,Hata J,Maejima K,Takano T

更新日期：1994-02-01 00:00:00

abstract：:Endocrine dysfunction in mitochondrial disease is commonplace, but predominantly restricted to disease of the endocrine pancreas resulting in diabetes mellitus. Other endocrine manifestations occur, but are relatively rare by comparison. In mitochondrial disease, neuromuscular symptoms often dominate the clinical phen...

journal_title：Molecular and cellular endocrinology

authors： Schaefer AM,Walker M,Turnbull DM,Taylor RW

更新日期：2013-10-15 00:00:00

abstract：:The proliferative effect of estrogens on breast cancer cell (BCC) is mainly mediated through estrogen receptors (ER). Non-transcriptional effects of estrogens, exerted through activation of several protein kinases, may also contribute to BCC proliferation. However, the relative contribution of these two responses to B...

journal_title：Molecular and cellular endocrinology

authors： Geffroy N,Guédin A,Dacquet C,Lefebvre P

更新日期：2005-06-15 00:00:00

abstract：:The control of progenitor cell proliferation in concert with terminal differentiation during embryonic development is poorly understood. The present paper examines this issue in the different cell lineages of the fetal mouse pituitary. Mouse fetuses were pulse-exposed to 3H-thymidine (3H-T) on a single day between emb...

journal_title：Molecular and cellular endocrinology

authors： Seuntjens E,Denef C

更新日期：1999-04-25 00:00:00

abstract：:Hypospadias is one of the most common congenital malformations. It is considered to be a mild form of the 46,XY disorders of sex development (DSD), but its precise etiology remains to be elucidated. Compromised androgen synthesis or effects can cause this frequent malformation, although the mutational analyses of the ...

journal_title：Molecular and cellular endocrinology

authors： Kalfa N,Philibert P,Baskin LS,Sultan C

更新日期：2011-03-30 00:00:00

abstract：:The phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) is a potent activator of protein kinase C (PKC) and is known to affect a variety of biochemical processes in human breast cancer cells. In the present study we have employed MCF-7 cells to investigate the effects of TPA on inositol lipid signalling, the puta...

journal_title：Molecular and cellular endocrinology

authors： Patel KV,Schrey MP

更新日期：1992-06-01 00:00:00

abstract：:Renin secretion was stimulated in rats by adrenalectomy (ADX), by treatment with the converting enzyme inhibitor enalapril (MK 421), or by feeding a low salt diet plus furosemide treatment (FUR). Relative amounts of renin mRNA were measured by densitometric Northern blot analysis using a 32P-labeled 700 bp mouse subma...

journal_title：Molecular and cellular endocrinology

authors： Ludwig G,Ganten D,Murakami K,Fasching U,Hackenthal E

更新日期：1987-04-01 00:00:00

abstract：:Transcription of the glycoprotein hormone alpha-subunit gene in the pituitary is governed by different promoter elements in thyrotropes and gonadotropes. We recently identified an upstream enhancer that directs a high level of cell type specific expression in transgenic mice and stimulates proximal promoter activity i...

journal_title：Molecular and cellular endocrinology

authors： Wood WM,Dowding JM,Sarapura VD,McDermott MT,Gordon DF,Ridgway EC

更新日期：1998-07-25 00:00:00

abstract：:The fish reproductive axis is regulated by many neuroendocrine factors. However, factors involved in the suppression of this axis are largely uncharacterized. In this study, we describe a novel neuropeptide derived from the spexin precursor acting as a negative factor to suppress the reproductive axis in teleost. The ...

journal_title：Molecular and cellular endocrinology

authors： Liu Y,Li S,Qi X,Zhou W,Liu X,Lin H,Zhang Y,Cheng CH

更新日期：2013-07-15 00:00:00

abstract：:Advanced glycation end products (AGEs), formed at an accelerated rate under diabetes, play a role in inflammation and fibrosis in mesangial areas in diabetic nephropathy (DN). However, the transcriptional modulator that mediates the cellular response to AGEs remains largely obscure. Our goal was to determine whether m...

journal_title：Molecular and cellular endocrinology

authors： Chen Q,Huang J,Gong W,Chen Z,Huang J,Liu P,Huang H

更新日期：2018-01-15 00:00:00

abstract：:Hepatic nuclear factor 4 alpha (HNF4α) drives the expression of apolipoprotein B (ApoB), microsomal triglyceride transfer protein (MTP) and phospholipase A2 G12B (PLA2G12B), governing hepatic very-low-density lipoprotein (VLDL) production and secretion. Andrographolide (AP) is a major constituent isolated from Androgr...

journal_title：Molecular and cellular endocrinology

authors： Zhang M,Yang M,Wang N,Liu Q,Wang B,Huang T,Tong Y,Ming Y,Wong CW,Liu J,Yao D,Guan M

更新日期：2020-08-01 00:00:00