Andrographolide modulates HNF4α activity imparting on hepatic metabolism.

abstract：:Our objective was to investigate the mechanisms by which the endogenous CRHR2 in white adipose tissue (WAT) regulates metabolic activities associated with lipogenesis and lipolysis under continuous exposure to hypoxia. We found that hypobaric hypoxia at a simulated altitude of 5000 m significantly reduced the body wei...

journal_title：Molecular and cellular endocrinology

authors： Xiong Y,Qu Z,Chen N,Gong H,Song M,Chen X,Du J,Xu C

更新日期：2014-07-05 00:00:00

abstract：:Spermatogonial transplantation as developed in the laboratory of Ralph Brinster has been a technological breakthrough in the study of Sertoli-germ cell interactions. For the first time, germ cells can be transferred from one animal to another and from one species to another. The transfer technology combined with devel...

journal_title：Molecular and cellular endocrinology

authors： Russell LD,Griswold MD

更新日期：2000-03-30 00:00:00

abstract：:Within the seminiferous tubules, the Sertoli cells create an impermeable blood-testis barrier and an unique intratubular microenvironment that fosters the development of spermatozoa. The functional differentiation of spermatozoa therefore requires vectorial secretion by Sertoli cells of substances that cannot cross th...

journal_title：Molecular and cellular endocrinology

authors： Spaliviero JA,Handelsman DJ

更新日期：1991-10-01 00:00:00

abstract：:The expression of the three genes encoding the components C1, C2 and C3 of prostatic binding protein (PBP) is under androgen control and restricted to the rat ventral prostate. The SstI-PvuII fragment of the first intron of the C3(1) gene displays two binding sites for ubiquitous transcription factors and one for a ti...

journal_title：Molecular and cellular endocrinology

authors： Celis L,Claessens F,Peeters B,Heyns W,Verhoeven G,Rombauts W

更新日期：1993-08-01 00:00:00

abstract：:Endometriosis causes pelvic pain and infertility in women of reproductive age. We explored TNFalpha-induced specific signaling pathways and gene expressions in endometriotic stromal cells (ESCs). Based on the data of the pathway specific cDNA array, we analyzed the role of TAK1, which is believed to work as a common m...

journal_title：Molecular and cellular endocrinology

authors： Taniguchi F,Harada T,Miyakoda H,Iwabe T,Deura I,Tagashira Y,Miyamoto A,Watanabe A,Suou K,Uegaki T,Terakawa N

更新日期：2009-08-13 00:00:00

abstract：:We examined the effects of growth hormone (GH), prolactin (PRL) and insulin-like growth factor-I (IGF-I) on DNA synthesis, and insulin-like growth factor binding protein 3 (IGFBP-3) gene expression, in a rat beta-cell line INS-1. GH and PRL were equally effective in increasing DNA synthesis and IGFBP-3 gene expression...

journal_title：Molecular and cellular endocrinology

authors： De W,Bréant B,Czernichow P,Asfari M

更新日期：1995-10-30 00:00:00

abstract：:Vaspin expression is increased in white adipose tissue (WAT) of diet-induced obese mice and rats and is supposed to compensate HFD-induced inflammatory processes and insulin resistance in adipose tissue by counteracting pro-inflammatory gene expression in obesity. Multiple studies have also demonstrated strong anti-in...

journal_title：Molecular and cellular endocrinology

authors： Zieger K,Weiner J,Krause K,Schwarz M,Kohn M,Stumvoll M,Blüher M,Heiker JT

更新日期：2018-01-15 00:00:00

abstract：:Eppin (epididymal protease inhibitor) is a member of the whey acidic protein (WAP)-type four-disulfide core (WFDC) gene family. This study provides updated information on Eppin and the Eppin-like genes within the Eppin cluster on human chromosome 20. A virtual structural model of the Eppin protein demonstrates that th...

journal_title：Molecular and cellular endocrinology

authors： O'Rand MG,Widgren EE,Wang Z,Richardson RT

更新日期：2006-05-16 00:00:00

abstract：:Foxp3+ regulatory T cells (Tregs) in lymphocytes facilitate the thyroid tumor growth and invasion. Very limited information is available on Foxp3 expression in thyroid cancer cells and its function is totally unknown. This study demonstrated that Foxp3 expression was increased in thyroid cancer cells. Inhibition of Fo...

journal_title：Molecular and cellular endocrinology

authors： Chu R,Liu SY,Vlantis AC,van Hasselt CA,Ng EK,Fan MD,Ng SK,Chan AB,Du J,Wei W,Liu X,Liu Z,Chen GG

更新日期：2015-01-05 00:00:00

abstract：:The effect of thyroid status on the postnatal development of the two molecular forms of Na+,K+-ATPase, distinguished kinetically on the basis of their ouabain sensitivity, was examined in rat brain. Hypothyroidism induced by PTU from day 1 postnatally significantly reduced the Na+,K+-ATPase activity in cerebellum (22-...

journal_title：Molecular and cellular endocrinology

authors： Atterwill CK,Reid J,Athayde CM

更新日期：1985-05-01 00:00:00

abstract：:The mouse mammary tumor virus (MMTV) initiates infection when the envelope protein, gp52, binds to a cell surface protein and triggers internalization. The hormonal regulation of this protein was studied both in vitro and in vivo. In mammary gland explant culture, levels of the MMTV binding protein were maintained onl...

journal_title：Molecular and cellular endocrinology

authors： Bolander FF Jr

更新日期：1991-12-01 00:00:00

abstract：:Recent evidence suggests that lymphocytes produce prolactin (PRL). Here, we report the cDNA cloning and expression of PRL from normal human thymocytes. Sequence analysis showed that the thymocyte cDNA encodes a 23 kDa protein which is identical to pituitary PRL. RNA blot analysis showed that the thymocyte PRL mRNA is ...

journal_title：Molecular and cellular endocrinology

authors： O'Neal KD,Montgomery DW,Truong TM,Yu-Lee LY

更新日期：1992-09-01 00:00:00

abstract：:Growth hormone (GH) and its mediator, the insulin-like growth factor-1 (IGF-1) regulate somatic growth, metabolism and many aspects of aging. As such, actions of GH/IGF have been studied in many tissues and organs over decades. GH and IGF-1 are part of the hypothalamic/pituitary somatotrophic axis that consists of man...

journal_title：Molecular and cellular endocrinology

authors： Dixit M,Poudel SB,Yakar S

更新日期：2021-01-01 00:00:00

abstract：:We used murine Ba/F3 cells transfected with human growth hormone receptor (hGHR) cDNA to investigate the regulatory mechanisms of human growth hormone-binding protein (hGH-BP) release. The extracellular domain of hGHRs were cleaved and released as hGH-BPs (a soluble form of hGHR). The hGH-BP release was enhanced by ph...

journal_title：Molecular and cellular endocrinology

authors： Takagi K,Saito Y,Sawada J

更新日期：2001-09-01 00:00:00

abstract：:Many rodent studies and a few non-human primate data report impairments of spatial and non-spatial memory induced by exposure to bisphenol A (BPA), which are associated with neural modifications, particularly in processes involved in synaptic plasticity. BPA-induced alterations involve disruption of the estrogenic pat...

journal_title：Molecular and cellular endocrinology

authors： Mhaouty-Kodja S,Belzunces LP,Canivenc MC,Schroeder H,Chevrier C,Pasquier E

更新日期：2018-11-05 00:00:00

abstract：:Although well-established, the underlying mechanisms involved in obesity-related plasma adiponectin decline remain elusive. Oxidative stress is associated with obesity and insulin resistance and considered to contribute to the progression toward obesity-related metabolic disorders. In this study, we investigated the e...

journal_title：Molecular and cellular endocrinology

authors： Wang Z,Dou X,Gu D,Shen C,Yao T,Nguyen V,Braunschweig C,Song Z

更新日期：2012-02-26 00:00:00

abstract：:Peritubular stem Leydig cells (SLCs) have been identified from rat testicular seminiferous tubules. However, no stem cells for peritubular myoid cells have been reported in the adult testis so far. In the present study, we tested the hypothesis that the peritubular SLCs are multipotent and able to form either Leydig o...

journal_title：Molecular and cellular endocrinology

authors： Zhao X,Wen X,Ji M,Guan X,Chen P,Hao X,Chen F,Hu Y,Duan P,Ge RS,Chen H

更新日期：2021-01-27 00:00:00

abstract：:Administration of hydrocortisone to adrenalectomised rats elevated levels of both free and membrane-bound polysomes in liver and led to marked shifts in their sedimentation profiles in favour of heavier polysomes. The rate of nascent polypeptide formation was also found to be enhanced in response to the hormone but th...

journal_title：Molecular and cellular endocrinology

authors： Kulkarni SB,Netrawali MS,Pradhan DS,Sreenivasan A

更新日期：1976-02-01 00:00:00

abstract：:Estrogen receptors (ers) not only are activated by hormones but also interact with many human-derived environmental contaminants. Here, we present evidence for four expressed er genes in Atlantic salmon cDNA - two more ers (erα2 and erβ2) than previously published. To determine if er gene expression differs between tw...

journal_title：Molecular and cellular endocrinology

authors： Nikoleris L,Hansson MC

更新日期：2015-01-15 00:00:00

abstract：:The effects of the preovulatory luteinizing hormone (LH) surge on the ovulatory process are mediated by prostaglandins (PGs), the synthesis of which involves prostaglandin synthetase and cytosolic phospholipase A2 (cPLA2). In our previous study, we systematically investigated the function of prostaglandin endoperoxide...

journal_title：Molecular and cellular endocrinology

authors： Tang H,Wang L,Chen Y,He J,Qu L,Guo Y,Liu Y,Liu X,Lin H

更新日期：2018-09-15 00:00:00

abstract：:The steroidogenic acute regulatory (StAR) protein regulates the rate-limiting step in steroidogenesis, i.e. the delivery of cholesterol from the outer (OMM) to the inner (IMM) mitochondrial membrane. StAR is a 37-kDa protein with an N-terminal mitochondrial targeting sequence that is cleaved off during mitochondrial i...

journal_title：Molecular and cellular endocrinology

authors： Castillo AF,Orlando U,Helfenberger KE,Poderoso C,Podesta EJ

更新日期：2015-06-15 00:00:00

abstract：:Cell-cell interactions are crucial role for the proper functioning of endocrine glands. We recently demonstrated that interactions of chromaffin and cortical cells are important for adrenocortical steroidogenesis. However, the molecular mechanisms have not been elucidated and it is unclear if this involves acute and/o...

journal_title：Molecular and cellular endocrinology

authors： Haidan A,Bornstein SR,Liu Z,Walsh LP,Stocco DM,Ehrhart-Bornstein M

更新日期：2000-07-25 00:00:00

abstract：:The effect of a gonadotropin-releasing hormone-agonist (GnRH-a) on the synthesis of insulin-like growth factor-binding protein-5 (IGFBP-5), a physiological marker for atresia, was investigated. Granulosa cells obtained from diethylstilbestrol (DES)-treated immature female rats were cultured in serum-free medium for 72...

journal_title：Molecular and cellular endocrinology

authors： Onoda N,Li D,Mickey G,Erickson G,Shimasaki S

更新日期：1995-04-28 00:00:00

abstract：:Detailed imaging of the pituitary gland is a prerequisite for a successful outcome of transsphenoidal hypophysectomy in dogs because it allows for accurate preoperative localization and assessment of the size of the pituitary gland. Cisternography allows assessment of even small increases in the height of the pituitar...

journal_title：Molecular and cellular endocrinology

authors： van der Vlugt-Meijer RH,Voorhout G,Meij BP

更新日期：2002-11-29 00:00:00

abstract：:The outcome and reproductive function were examined among patients with malignant ovarian germ cell tumors treated since 1980. Between 1980 and 2001, fertility-sparing surgery was performed in 26 women, 23 of whom received adjuvant chemotherapy. With a median follow-up of 66.6 months, all patients have been alive, wit...

journal_title：Molecular and cellular endocrinology

authors： Sagae S,Sasaki H,Nishioka Y,Terasawa K,Kudo R

更新日期：2003-04-28 00:00:00

abstract：:Experiments were done to determine the actions of ACTH on the morphologic and functional characteristics of the zona fasciculata (ZF) and zona reticularis (ZR) in the guinea pig adrenal cortex. In control guinea pigs, a number of morphologic differences distinguished the ZF from the ZR, including the presence of far m...

journal_title：Molecular and cellular endocrinology

authors： Yuan BB,Tchao R,Funae Y,Voigt JM,Colby HD

更新日期：1998-11-25 00:00:00

abstract：:To elucidate the molecular mechanism in relation to vascular supply and osteoporosis, we investigated the effect of hypoxia on Runx2 expression in MG63 cells. Also investigated was expression of type I collagen and osteocalcin, which are regulated by Runx2, alkaline phosphatase (ALPase) to see if they are affected by ...

journal_title：Molecular and cellular endocrinology

authors： Park JH,Park BH,Kim HK,Park TS,Baek HS

更新日期：2002-06-28 00:00:00

abstract：:Recent evidences point to a role of estrogens in males. We have earlier reported that tamoxifen, a synthetic non-steroidal antiestrogen, when administered to adult male rats, in the dose range of 0.04-0.4 mg/kg per day, reduced fertility. The reduced fertility was measured in terms of fertility index (a measure of the...

journal_title：Molecular and cellular endocrinology

authors： Balasinor N,Parte P,Gill-Sharma MK,Juneja HS

更新日期：2001-06-10 00:00:00

abstract：:Lipoprotein lipase (LPL) activity is known to be synthesized, active and functional in the 1-day-old rat liver: it peaks just at birth triggered by parturition. During suckling LPL mRNA, LPL synthesis and LPL activity are still high at 5 days and then fade reaching adult values at weaning. How LPL expression is gradua...

journal_title：Molecular and cellular endocrinology

authors： Julve J,Robert MQ,Llobera M,Peinado-Onsurbe J

更新日期：1996-01-15 00:00:00

abstract：:Systemic administration of endotoxin, which closely mimics the bacteria-induced systemic inflammatory response syndrome (SIRS) can ultimately lead to organ failure. Adrenal gland insufficiency is frequently diagnosed in critically ill patients; however, the underlying mechanisms are still unclear. In the present study...

journal_title：Molecular and cellular endocrinology

authors： Kanczkowski W,Chatzigeorgiou A,Samus M,Tran N,Zacharowski K,Chavakis T,Bornstein SR

更新日期：2013-05-22 00:00:00