Hepato-pancreato-biliary lesions are present in both Carney complex and McCune Albright syndrome: comments on P. Salpea and C. Stratakis.

abstract：:GLP-1, incretin with insulin-independent antidiabetic properties, is insulinomimetic upon glucose metabolism in extrapancreatic tissues, acting through specific receptors not associated to adenylate cyclase activation. We investigated the role of enzymes mediating insulin actions, in the GLP-1-induced glycogen synthas...

journal_title：Molecular and cellular endocrinology

authors： Redondo A,Trigo MV,Acitores A,Valverde I,Villanueva-Peñacarrillo ML

更新日期：2003-06-30 00:00:00

abstract：:Cyclic ewes were treated with control vehicle or progesterone receptor antagonist (onapristone; 100mg i.m. twice daily) during either early (day 3-5) or late (day 12-14) luteal phase and plasma samples collected for hormone analysis and to determine endogenous and oxytocin induced PGF2α release. On day 14 and 17, ewes...

journal_title：Molecular and cellular endocrinology

authors： Mann GE,Wathes DC,Robinson RS

更新日期：2013-08-25 00:00:00

abstract：:Induction of prolactin hepatic receptors in the male rat by exogenous prolactin and the possible involvement of prostaglandins in this process were studied. When ovine prolactin 500 microgram/kg was administered sc in saline containing 10% PVP (polyvinylpyrrolidone), twice daily for 6.5 days and the rats killed 48 h a...

journal_title：Molecular and cellular endocrinology

authors： Barkey RJ,Shani J,Lahav M,Amit T,Youdim MB

更新日期：1981-02-01 00:00:00

abstract：:In the present paper the effects of 17beta-estradiol on the expression of the preprosomatostatin 1 (PSS1) in the orange-spotted grouper hypothalamus and ovary were investigated. Results from in vivo of intraperitoneal injection and in vitro static cultures showed that estradiol increased the mRNA expression of PSS1 ge...

journal_title：Molecular and cellular endocrinology

authors： Zhang L,Li W,Hong X,Lin H

更新日期：2009-11-13 00:00:00

abstract：:Endocrine disrupting chemicals are known to cause neurodevelopmental toxicity through direct and indirect pathways. In this study we used data from the National Health and Nutrition Examination Surveys, along with known exposure-disease relationships, to quantify the intellectual disability burden attributable to in u...

journal_title：Molecular and cellular endocrinology

authors： Gaylord A,Osborne G,Ghassabian A,Malits J,Attina T,Trasande L

更新日期：2020-02-15 00:00:00

abstract：:Explants from the mammary gland of 6 lactating cows were cultured in M-199 medium containing insulin (1.0 micrograms/ml) and hydrocortisone (0.5 micrograms/ml) and supplemented with bPRL (0.2-1.0 micrograms/ml) or oGH (0.1, 0.5 and 2.5 micrograms/ml) or bGH or hGH (0.2 and 1.0 micrograms/ml). It was found that neither...

journal_title：Molecular and cellular endocrinology

authors： Gertler A,Cohen N,Maoz A

更新日期：1983-12-01 00:00:00

abstract：:The study aims to examine the effects of restraint, cold, and in combination of hypoxia on pituitary GH mRNA and hepatic IGF-I mRNA and its protein in rats, and the potential involvement of corticotropin-releasing factor receptor subtype 1 (CRFR1) and SS in mediating the effects of continual hypoxia. Continual or inte...

journal_title：Molecular and cellular endocrinology

authors： Chen XQ,Xu NY,Du JZ,Wang Y,Duan C

更新日期：2005-10-20 00:00:00

abstract：:The interaction of indomethacin with the antilipolytic effect of prostaglandin E2 (PGE2) was investigated in rat adipocytes in order to reveal a possible role of endogenous PGs in adipose tissue. Adipocytes isolated from rats treated in vivo for 5 days with indomethacin were compared with non-treated control rats. The...

journal_title：Molecular and cellular endocrinology

authors： Richelsen B

更新日期：1988-07-01 00:00:00

abstract：:Northern blot analysis of total RNA from a variety of rabbit tissues indicated that placenta is the primary site of expression of the protein hormone relaxin (previously called SQ10) in rabbits. Relaxin was not detected by this method in other rabbit tissues, including normal trachea and several squamous tissues. Howe...

journal_title：Molecular and cellular endocrinology

authors： Bernacki SH,Medvedev A,Holloway G,Dawson M,Lotan R,Jetten AM

更新日期：1998-03-16 00:00:00

abstract：:Glucocorticoids are steroid hormones of the adrenal gland that are an integral component of the stress response and regulate many physiological processes, including metabolism and immune response. Their release into the blood is highly dynamic and occurs in about hourly pulses, the amplitude of which is modulated in a...

journal_title：Molecular and cellular endocrinology

authors： Dickmeis T,Weger BD,Weger M

更新日期：2013-11-05 00:00:00

abstract：:Recently, a defect in pertussis toxin-independent actions of epinephrine on pancreatic B-cells of fa/fa Zucker rats was reported (Cawthorn and Chan (1991) Mol. Cell. Endocrinol. 75, 197-204). We now report studies of islet alpha 2-adrenoceptor function of fa/fa rats. Insulin and cAMP production by islets of obese rats...

journal_title：Molecular and cellular endocrinology

authors： Chan CB,MacPhail RM

更新日期：1992-03-01 00:00:00

abstract：:Recent evidence using GT1-7 cells indicates that GnRH pulsatility depends on exocytotic-release and gene transcription events. To determine whether calcium or DREAM may play a role in linking these processes, we used an L-type Ca(2+)-blocker (nimodipine) and found that not only GnRH gene expression (GnRH-GE) pulse act...

journal_title：Molecular and cellular endocrinology

authors： Leclerc GM,Boockfor FR

更新日期：2007-03-15 00:00:00

abstract：:Trophoblast cells produce several inmmuneregulators like the Vasoactive Intestinal Peptide (VIP) and P4 targeting multiple circuits, and also display an intese phagocytic ability allowing embryo implantation in a tolerogenic context. Here, we explored whether P4 and VIP- crosstalk modulates trophoblast cell function, ...

journal_title：Molecular and cellular endocrinology

authors： Vota D,Aguero M,Grasso E,Hauk V,Gallino L,Soczewski E,Pérez Leirós C,Ramhorst R

更新日期：2017-03-05 00:00:00

abstract：:To elucidate the molecular mechanism in relation to vascular supply and osteoporosis, we investigated the effect of hypoxia on Runx2 expression in MG63 cells. Also investigated was expression of type I collagen and osteocalcin, which are regulated by Runx2, alkaline phosphatase (ALPase) to see if they are affected by ...

journal_title：Molecular and cellular endocrinology

authors： Park JH,Park BH,Kim HK,Park TS,Baek HS

更新日期：2002-06-28 00:00:00

abstract：:Transcriptional regulation of the human parathyroid hormone-related protein (PTHrP) gene by calcitonin was examined in a lung cancer line (BEN cells). Northern analysis demonstrated that calcitonin caused a rapid 4.5-fold elevation in PTHrP mRNA. Transient transfection of a construct containing 1119 base pairs of the ...

journal_title：Molecular and cellular endocrinology

authors： Chilco PJ,Gerardi JM,Kaczmarczyk SJ,Chu S,Leopold V,Zajac JD

更新日期：1993-07-01 00:00:00

abstract：:Our objective was to investigate the mechanisms by which the endogenous CRHR2 in white adipose tissue (WAT) regulates metabolic activities associated with lipogenesis and lipolysis under continuous exposure to hypoxia. We found that hypobaric hypoxia at a simulated altitude of 5000 m significantly reduced the body wei...

journal_title：Molecular and cellular endocrinology

authors： Xiong Y,Qu Z,Chen N,Gong H,Song M,Chen X,Du J,Xu C

更新日期：2014-07-05 00:00:00

abstract：:Previous studies have shown that disruption or damage to the seminiferous tubules by radiation, antiandrogen, vitamin A deficiency or experimental cryptorchidism causes Leydig cell hypertrophy and hyperplasia, suggesting that Sertoli cells secrete a mitogenic factor(s) that stimulates Leydig cell proliferation. To stu...

journal_title：Molecular and cellular endocrinology

authors： Wu N,Murono EP

更新日期：1994-12-01 00:00:00

abstract：:Human placenta produces melatonin and expresses its receptors. We propose that melatonin, an antioxidant, protects the human placenta against hypoxia/reoxygenation (H/R)-induced damage. Primary term villous cytotrophoblasts were cultured under normoxia (8% O2) with or without 1mM melatonin for 72h to induce differenti...

journal_title：Molecular and cellular endocrinology

authors： Lanoix D,Lacasse AA,Reiter RJ,Vaillancourt C

更新日期：2013-12-05 00:00:00

abstract：:As part of an ongoing study of the cell-specific expression of glandular kallikrein genes in mice, we have investigated cellular sites of expression of the renal/pancreatic kallikrein gene, mGK-6, during fetal life. Expression of alpha I and beta-subunit genes of Na+K+ATPase and bradykinin binding were used as an indi...

journal_title：Molecular and cellular endocrinology

authors： Penschow JD,Coghlan JP

更新日期：1992-10-01 00:00:00

abstract：:The present study was aimed at characterizing the deficiency of the glucocorticoid-receptor system in the immature pituitary gland of neonatal rats. Under conditions of both constant protein and DNA concentrations, [3H]dexamethasone binding to nuclei was significantly lower in the immature, compared with the mature, g...

journal_title：Molecular and cellular endocrinology

authors： Sakly M,Koch B

更新日期：1982-09-01 00:00:00

abstract：:HE6 (GPR64) is a highly conserved, tissue-specific heptahelical receptor of the human epididymis. The seven transmembrane (TM7) domains are a hallmark of G-protein-coupled receptors (GPCRs) which have a proven history of being excellent therapeutic targets. Of all currently marketed drugs, >30% are modulators of speci...

journal_title：Molecular and cellular endocrinology

authors： Kirchhoff C,Obermann H,Behnen M,Davies B

更新日期：2006-05-16 00:00:00

abstract：:At 14 days of age, hypothyroid and normal rats are rendered hypoglycaemic by insulin injection and the subsequent induction in adrenal tyrosine hydroxylase (TH) is studied. Hypothyroidism impairs both the intensity and the time-course of adrenal TH induction. ...

journal_title：Molecular and cellular endocrinology

authors： Gripois D,Valens M

更新日期：1984-11-01 00:00:00

abstract：:The higher prevalence of thyroid disease in women suggests that estrogen (E2) might be involved in the pathophysiology of thyroid dysfunction. To approach the question of the effect of stromal cells in the modulation of thyroid epithelial cells activity, we established and characterized a homogeneous stromal cell popu...

journal_title：Molecular and cellular endocrinology

authors： Gantus MA,Alves LM,Stipursky J,Souza EC,Teodoro AJ,Alves TR,Carvalho DP,Martinez AM,Gomes FC,Nasciutti LE

更新日期：2011-04-30 00:00:00

abstract：:Stanniocalcin (STC) (formerly known as both teleocalcin and hypocalcin) is an anti-hypercalcemic, glycoprotein hormone that is produced by the corpuscles of Stannius (CS), endocrine glands that are confined to bony fishes. The hormone has a unique amino acid sequence and exists as a disulfide-linked homodimer in the n...

journal_title：Molecular and cellular endocrinology

authors： Wagner GF,Dimattia GE,Davie JR,Copp DH,Friesen HG

更新日期：1992-12-01 00:00:00

abstract：:Monoclonal antibodies generated to ovine prolactin were screened for their ability to neutralize the biological activity of prolactin from several species. By Western blot analysis, antibody 6F11 cross-reacted strongly with prolactin in homogenates of anterior pituitary glands from squirrel monkey, sheep and rat. In a...

journal_title：Molecular and cellular endocrinology

authors： Scammell JG,Wear LB,Von Haven R

更新日期：1990-06-18 00:00:00

abstract：:Thyroid hormone receptor alpha (TRalpha) and the oncoprotein v-erbA (a mutated form of TRalpha incapable of binding T3) bind as heterodimers with retinoid X receptor (RXR) to DNA sequences with different orientations of AGGTCA half sites. v-erbA can also form homodimers, whereas, TRalpha1 homodimerizes poorly. Therefo...

journal_title：Molecular and cellular endocrinology

authors： Zubkova I,Subauste JS

更新日期：2003-01-31 00:00:00

abstract：:T3 effects on myosin heavy chain gene expression were analysed in muscles undergoing different fates during metamorphosis. Muscle fate was followed by somatic gene transfer of a constitutively expressed luciferase vector. Persistent expression was found in dorsal muscle which is remodelled during metamorphosis whilst ...

journal_title：Molecular and cellular endocrinology

authors： Sachs LM,Lebrun JJ,de Luze A,Kelly PA,Demeneix BA

更新日期：1997-08-08 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF-alpha) was found to induce type-1 plasminogen activator inhibitor (PAI-1) antigen in the human fibrosarcoma cell line HT-1080, and PAI-1 and urokinase-type plasminogen activator (u-PA) antigens in the human carcinoma cell line T-CAR1; tissue-type plasminogen activator (t-PA) antigen wa...

journal_title：Molecular and cellular endocrinology

authors： Georg B,Helseth E,Lund LR,Skandsen T,Riccio A,Danø K,Unsgaard G,Andreasen PA

更新日期：1989-01-01 00:00:00

abstract：:Mammalian spermatozoa undergo several signaling and biochemical transformations in the female genital tract, collectively called capacitation. The capacitated spermatozoon binds to the egg zona pellucida, where it undergoes the acrosome reaction (AR), a process enabling it to penetrate and fertilize the egg. Actin pol...

journal_title：Molecular and cellular endocrinology

authors： Breitbart H,Rotman T,Rubinstein S,Etkovitz N

更新日期：2010-01-27 00:00:00

abstract：:The electrophoretic mobility and surface charge of thymocytes was reduced on incubation of the cells with growth hormone in vitro. All cells in thymus were not found to be sensitive to the hormone. The proportion of cells whose surface charge was altered by the hormone was 65% in the thymocytes from 5-week-old rats. T...

journal_title：Molecular and cellular endocrinology

authors： Hanjan SN,Talwar GP

更新日期：1975-09-01 00:00:00