Role and regulation of PI3K in sperm capacitation and the acrosome reaction.

abstract：:The cell line MD-IGF-1, containing an ovine IGF-1 cDNA driven by the mouse mammary tumor virus-long terminal repeat (MMTV-LTR) promoter, was used to study expression of IGF-1 linked to the MMTV-LTR in bovine mammary epithelial cells in response to various hormonal and substratum stimuli. Acute sensitivity of the MMTV-...

journal_title：Molecular and cellular endocrinology

authors： Romagnolo D,Akers RM,Wong EA,Boyle PL,McFadden TB,Byatt JC,Turner JD

更新日期：1993-10-01 00:00:00

abstract：:Octopamine serves as a neurotransmitter in the glandular lobe of the locust corpus cardiacum where it regulates adipokinetic hormone (AKH) secretion from intrinsic neurosecretory cells. Two AKHs (AKH I and II) from the corpus cardiacum of Locusta have been sequenced and synthesized. We have now demonstrated that octop...

journal_title：Molecular and cellular endocrinology

authors： Pannabecker T,Orchard I

更新日期：1986-12-01 00:00:00

abstract：:This study examines the effect of preincubation of sheep ovarian follicles with hCG or FSH on the ability of isolated theca and granulosa to increase cAMP levels in response to a second incubation with hCG or FSH. Secondly, the effect of preincubation of small follicles with hCG on androstenedione and testosterone pro...

journal_title：Molecular and cellular endocrinology

authors： Weiss TJ,Armstrong DT

更新日期：1979-03-01 00:00:00

abstract：:In all mammalian species, the final differentiation of the male germ cell occurs in the epididymal duct where the spermatozoa develop the ability to be motile and fertilize an ovum. Understanding of these biological processes is the key to understanding and controlling male fertility. Comparative studies between sever...

journal_title：Molecular and cellular endocrinology

authors： Dacheux JL,Belleannée C,Jones R,Labas V,Belghazi M,Guyonnet B,Druart X,Gatti JL,Dacheux F

更新日期：2009-07-10 00:00:00

abstract：:Acid-labile subunit (ALS) deficiency (ACLSD) constitutes the first monogenic defect involving a member of the Insulin-like Growth Factor (IGF) binding protein system. The lack of ALS completely disrupts the circulating IGF system. Autocrine/paracrine action of local produced IGF-I could explain the mild effect on grow...

journal_title：Molecular and cellular endocrinology

authors： Domené S,Domené HM

更新日期：2020-12-01 00:00:00

abstract：:A major change in thyroid setpoint regulation occurs in various clinical conditions such as critical illness and psychiatric disorders. As a first step towards identifying determinants of these setpoint changes, we have studied the distribution and expression of thyroid hormone receptor (TR) isoforms, type 2 and type ...

journal_title：Molecular and cellular endocrinology

authors： Fliers E,Unmehopa UA,Alkemade A

更新日期：2006-06-07 00:00:00

abstract：:Osteoblastic metastases are common in patients with advanced prostate cancer. The pathophysiology of the new bone formation at metastatic sites is not currently known, but it is hypothesized that growth factors secreted by the prostate may be involved. Unfortunately, most rodent models of prostate cancer with metastas...

journal_title：Molecular and cellular endocrinology

authors： LeRoy BE,Bahnson RR,Rosol TJ

更新日期：2002-11-29 00:00:00

abstract：:All biologic responses to vitamin D are now known to arise as a consequence of the metabolism of this seco-steroid into its two principal biologically active metabolites 1alpha,25(OH)(2)-vitamin D(3) (1ALPHA;,25(OH)(2)D(3)) and 24R,25(OH)(2)-vitamin D(3) (24R,25(OH)(2)D(3)). 1alpha,25(OH)(2)D(3) is the dominant metabo...

journal_title：Molecular and cellular endocrinology

authors： Norman AW,Okamura WH,Bishop JE,Henry HL

更新日期：2002-11-29 00:00:00

abstract：:Inhibin production by cultured granulosa cells from immature diethylstilbestrol (DES)-primed rats was studied in relation to estradiol and progesterone production. The inhibin content in culture media was assayed with a specific radioimmunoassay (RIA) using an antibody to porcine 32 kDa inhibin that recognizes rat inh...

journal_title：Molecular and cellular endocrinology

authors： Suzuki T,Miyamoto K,Hasegawa Y,Abe Y,Ui M,Ibuki Y,Igarashi M

更新日期：1987-12-01 00:00:00

abstract：:Polycystic Ovary Syndrome (PCOS) is the most common endocrine disorder amongst women of reproductive age, whose aetiology remains unclear. To improve our understanding of the molecular mechanisms underlying the disease, we conducted a genome-wide DNA methylation profiling in granulosa lutein cells collected from 16 wo...

journal_title：Molecular and cellular endocrinology

authors： Makrinou E,Drong AW,Christopoulos G,Lerner A,Chapa-Chorda I,Karaderi T,Lavery S,Hardy K,Lindgren CM,Franks S

更新日期：2020-01-15 00:00:00

abstract：:Knowledge of the mechanisms of single dominant follicle selection has led to the development of a novel and effective ovulation induction regimen for anovulatory women; the step down protocol. This commences with a fixed high gonadotropin dose followed by several decremental steps. For some patients the initial dose i...

journal_title：Molecular and cellular endocrinology

authors： Macklon NS,Fauser BC

更新日期：2002-01-25 00:00:00

abstract：:A cell culture line has been derived from lymphosarcoma P1798. Cells will not divide in the prescence of 10(-8) M dexamethasone. Half-maximal inhibition of proliferation occurs at about 10(-9) M. Half-maximal inhibition of [3H] thymidine incorporation occurs at somewhat higher concentrations of dexamethasone. When cel...

journal_title：Molecular and cellular endocrinology

authors： Thompson EA Jr

更新日期：1980-02-01 00:00:00

abstract：:Recent evidence using GT1-7 cells indicates that GnRH pulsatility depends on exocytotic-release and gene transcription events. To determine whether calcium or DREAM may play a role in linking these processes, we used an L-type Ca(2+)-blocker (nimodipine) and found that not only GnRH gene expression (GnRH-GE) pulse act...

journal_title：Molecular and cellular endocrinology

authors： Leclerc GM,Boockfor FR

更新日期：2007-03-15 00:00:00

abstract：:Enzymatically dispersed rat pituitary cells were grown in primary culture, and LHRH-stimulated LH secretion was measured. Testosterone (T) decreased and 17 beta-estradiol (E) increased pituitary responsiveness to LHRH. The effect of E on LH secretion was partly due to an increase in LH content. There was a latent peri...

journal_title：Molecular and cellular endocrinology

authors： Kamel F,Krey LC

更新日期：1982-04-01 00:00:00

abstract：:The trafficking of fatty acids into and out of adipocytes is regulated by a complex series of proteins and enzymes and is under control by a variety of hormonal and metabolic factors. The biochemical basis of fatty acid influx, despite its widespread appreciation, remains enigmatic with regard to the biophysical and b...

journal_title：Molecular and cellular endocrinology

authors： Thompson BR,Lobo S,Bernlohr DA

更新日期：2010-04-29 00:00:00

abstract：:The so-called calcium antagonist D-600 and agents that enhance the influx of calcium ions into nerve terminals during action potentials (4-aminopyridine, tetraethylammonium, guanidine) interact with alpha-adrenoceptors. The interaction was revealed by binding experiments in vitro with the alpha 2- and alpha 1-specific...

journal_title：Molecular and cellular endocrinology

authors： Glossmann H,Hornung R

更新日期：1980-09-01 00:00:00

abstract：:Bone tissue is especially receptive to physical stimulation and agents with the capacity to mimic the signalling incurred via mechanical loading on osteoblasts may find an application in a bone regenerative setting. Recently this laboratory revealed that the major serum lipid, lysophosphatidic acid (LPA), co-operated ...

journal_title：Molecular and cellular endocrinology

authors： Mansell JP,Farrar D,Jones S,Nowghani M

更新日期：2009-06-16 00:00:00

abstract：:This study demonstrates that a single subcutaneous injection of gonadotrophin-releasing hormone (GnRH) (60 ng) to GnRH-deficient (hpg) male mice causes a doubling of pituitary GnRH receptors (GnRH-R). No change in GnRH-R occurs during the time of LH release (15-60 min) or up until 4 h post-GnRH. Between 4 and 12 h the...

journal_title：Molecular and cellular endocrinology

authors： Detta A,Naik SI,Charlton HM,Young LS,Clayton RN

更新日期：1984-09-01 00:00:00

abstract：:Regulation of the ovalbumin (Ov) gene is strictly controlled by precise developmental, tissue-specific, and hormonal cues. The Ov gene is transcriptionally activated by four classes of steroid hormones: estrogens, androgens, glucocorticoids, and progestins. Although it has served as a model to study multi-hormone gene...

journal_title：Molecular and cellular endocrinology

authors： Dillner NB,Sanders MM

更新日期：2002-06-28 00:00:00

abstract：:CYP11A1 encodes the P450scc enzyme that catalyzes the first and rate-limiting step of steroid biosynthesis. It is expressed in the adrenals and gonads under the control of pituitary peptide hormones. Transcription factor SF-1, which binds to the CYP11A1 promoter, plays an important role in the tissue-specific and horm...

journal_title：Molecular and cellular endocrinology

authors： Hu MC,Hsu HJ,Guo IC,Chung BC

更新日期：2004-02-27 00:00:00

abstract：:Low-grade inflammation links obesity, insulin resistance, and cardiovascular diseases. We investigated the effects of laparoscopic sleeve gastrectomy (LSG) on expression profile of genes involved in inflammatory pathways in subcutaneous adipose tissue (SCAT) and peripheral monocytes (PM). At baseline, obese group had ...

journal_title：Molecular and cellular endocrinology

authors： Trachta P,Dostálová I,Haluzíková D,Kasalický M,Kaválková P,Drápalová J,Urbanová M,Lacinová Z,Mráz M,Haluzík M

更新日期：2014-03-05 00:00:00

abstract：:Little is known about the regulation and cellular distribution of androgen receptors (ARs) in female rodent brains at various stages of the oestrous cycle. This information is critical for further studies of androgen signalling in the regulation of brain function under physiological and pathophysiological conditions. ...

journal_title：Molecular and cellular endocrinology

authors： Feng Y,Weijdegård B,Wang T,Egecioglu E,Fernandez-Rodriguez J,Huhtaniemi I,Stener-Victorin E,Billig H,Shao R

更新日期：2010-06-10 00:00:00

abstract：:This study was aimed to improve knowledge about swine ovarian follicular function, paying attention to angiogenesis, since new vessel growth is a fundamental event in ovarian function. In particular, we investigated a potential involvement of netrin-1, a protein known as a guidance axon factor. Firstly, we studied the...

journal_title：Molecular and cellular endocrinology

authors： Basini G,Cortimiglia C,Baioni L,Bussolati S,Grolli S,Ramoni R,Grasselli F

更新日期：2011-01-01 00:00:00

abstract：:We have investigated protein kinase C (PKC) regulation by 1,25-(OH)2D3 in the rat osteosarcoma cell line ROS 17/2.8 since previous reports have implicated PKC in the 1,25-(OH)2D3-mediated regulation of osteocalcin gene expression (J. Biol. Chem. 267 (1992) 12562; Endocrinology 136 (1995) 5685). Here we report that 1,2...

journal_title：Molecular and cellular endocrinology

authors： Rivera-Bermúdez MA,Bertics PJ,Albrecht RM,Mosavin R,Mellon WS

更新日期：2002-02-25 00:00:00

abstract：:Glucocorticoids play a primary role in the maturation of fetal organs and may contribute to the onset of labour. Glucocorticoid activity depends on the 11β-hydroxysteroid dehydrogenase family (11β-HSDs), catalysing the interconversion between "active" cortisol into inactive cortisone. No definitive study exists on 11β...

journal_title：Molecular and cellular endocrinology

authors： Damiani F,Makieva S,Rinaldi SF,Hua L,Marcolongo P,Petraglia F,Norman JE

更新日期：2017-05-15 00:00:00

abstract：:In the extracellular space, the gonadotropin-releasing hormone (GnRH) is metabolized by the zinc metalloendopeptidase EC3.4.24.15 (EP24.15) to form the pentapeptide, GnRH-(1-5). GnRH-(1-5) diverges in function and mechanism of action from GnRH in the brain and periphery. GnRH-(1-5) acts on the orphan G protein-coupled...

journal_title：Molecular and cellular endocrinology

authors： Cho-Clark M,Larco DO,Zahn BR,Mani SK,Wu TJ

更新日期：2015-11-05 00:00:00

abstract：:The production of glucocorticoids and aldosterone in the adrenal cortex is regulated at multiple levels. Biosynthesis of these hormones is initiated when cholesterol, the substrate, enters the inner mitochondrial membrane for conversion to pregnenolone. Unlike most metabolic pathways, the biosynthesis of adrenocortica...

journal_title：Molecular and cellular endocrinology

authors： Sewer MB,Li D

更新日期：2013-05-22 00:00:00

abstract：:Adipose tissue develops from differentiating preadipocytes that expand and migrate. 3T3-L1 preadipocytes respond to melanin-concentrating hormone (MCH) by increasing leptin production. Here, we investigate whether MCH elicits remodeling of the actin cytoskeleton and whether this translates into altered migratory capac...

journal_title：Molecular and cellular endocrinology

authors： Cook LB,Shum L,Portwood S

更新日期：2010-05-14 00:00:00

abstract：:Aggresome formation, a cellular response to misfolded protein aggregates, is linked to cancer and neurodegenerative disorders. Previously we showed that Gag-v-ErbA (v-ErbA), a retroviral variant of the thyroid hormone receptor (TRα1), accumulates in and sequesters TRα1 into cytoplasmic foci. Here, we show that foci re...

journal_title：Molecular and cellular endocrinology

authors： Bondzi C,Brunner AM,Munyikwa MR,Connor CD,Simmons AN,Stephens SL,Belt PA,Roggero VR,Mavinakere MS,Hinton SD,Allison LA

更新日期：2011-01-30 00:00:00

abstract：:Placental leptin secretion has important implications for maternal adaptation to pregnancy, fetal growth and development, and local autocrine/paracrine actions within trophoblast. In this study we used a cell culture insert model to examine directional secretion of leptin from the basal and apical surfaces of human ch...

journal_title：Molecular and cellular endocrinology

authors： Wyrwoll CS,Mark PJ,Waddell BJ

更新日期：2005-09-28 00:00:00