Abstract:
:The production of glucocorticoids and aldosterone in the adrenal cortex is regulated at multiple levels. Biosynthesis of these hormones is initiated when cholesterol, the substrate, enters the inner mitochondrial membrane for conversion to pregnenolone. Unlike most metabolic pathways, the biosynthesis of adrenocortical steroid hormones is unique because some of the enzymes are localized in mitochondria and others in the endoplasmic reticulum (ER). Although much is known about the factors that control the transcription and activities of the proteins that are required for steroid hormone production, the parameters that govern the exchange of substrates between the ER and mitochondria are less well understood. This short review summarizes studies that have begun to provide insight into the role of the cytoskeleton, mitochondrial transport, and the physical interaction of the ER and mitochondria in the production of adrenocortical steroid hormones.
journal_name
Mol Cell Endocrinoljournal_title
Molecular and cellular endocrinologyauthors
Sewer MB,Li Ddoi
10.1016/j.mce.2012.11.014subject
Has Abstractpub_date
2013-05-22 00:00:00pages
79-86issue
1-2eissn
0303-7207issn
1872-8057pii
S0303-7207(12)00506-0journal_volume
371pub_type
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journal_title:Molecular and cellular endocrinology
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更新日期:1993-05-01 00:00:00
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更新日期:1997-11-30 00:00:00
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