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Differential impact of oleate, palmitate, and adipokines on expression of NF-κB target genes in human vascular smooth muscle cells.

Abstract：

:It is widely accepted that obesity is a major risk factor for the development of atherosclerosis. In this context, adipose tissue produces a variety of adipokines and releases free fatty acids, contributing to a chronic-low grade inflammation state implicated in vascular complications. In this study, we investigated the role of adipokines, oleic acid (OA), palmitic acid (PA), and the combinations on activation of NF-κB target genes in human vascular smooth muscle cells (SMC) to assess the hypothesis of synergistic interactions between these molecules. Adipocyte-conditioned medium (CM), generated from human adipocytes, in combination with low concentrations of OA, but not PA, induces SMC proliferation and activation of the transcription factor NF-κB in a synergistic way. Combined treatment of CM and OA further regulates a set of downstream NF-κB target genes including angiopoietin-1, activin A, and MMP-1, all critically involved in SMC dysfunction. This suggests that the lipotoxic potential of fatty acids is substantially enhanced by the presence of adipocyte-derived factors.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Lamers D,Schlich R,Horrighs A,Cramer A,Sell H,Eckel J

doi

10.1016/j.mce.2012.06.010

subject

Has Abstract

pub_date

2012-10-15 00:00:00

pages

194-201

issue

1-2

eissn

0303-7207

issn

1872-8057

pii

S0303-7207(12)00324-3

journal_volume

362

pub_type

杂志文章

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