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Bradykinin stimulates prostaglandin E2 release in human skeletal muscular fibroblasts.

Abstract：

:Local mediator prostaglandins and bradykinin are involved in inflammation and pain. We explored bradykinin effects on prostaglandin E2 (PGE2) release from fibroblasts derived from human skeletal muscular biopsies. Bradykinin induced PGE2 release through bradykinin B2 receptors, since PGE2 release was blocked by the bradykinin B2 receptor selective antagonist FR173657 and B2 receptor agonist (Hyp3)-bradykinin showed effects comparable to bradykinin. Consistently, bradykinin induced both mRNA cyclooxygenase 2 (COX-2) and protein. Bradykinin also induced ERK1/2 and p38 phosphorylation and provoked the translocation from the cytosol to the nucleus of p65/NF-kB. The release of PGE2 by bradykinin could be blocked inhibiting COX-2 and p65/NF-kB, ERK1/2 or p38 activation. Both ERK1/2 and p38 were upstream to NF-kB inasmuch siRNAs significantly blocked the p65/NF-kB activation induced by bradykinin. Thus, bradykinin, acting via B2 receptors, induced PGE2 release through ERK1/2 and p38-dependent pathways and consequent p65/NF-kB translocation to nucleus. p65/NF-kB induced COX-2 transcription. The release of PGE2 provide a possible explanation for the role of bradykinin in inflammatory diseases.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Muscella A,Cossa LG,Vetrugno C,Marsigliante S

doi

10.1016/j.mce.2020.110771

subject

Has Abstract

pub_date

2020-05-01 00:00:00

pages

110771

eissn

0303-7207

issn

1872-8057

pii

S0303-7207(20)30071-X

journal_volume

507

pub_type

杂志文章

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