The effect of beta-endorphin on rat oocyte maturation in vitro.

abstract：:The availability of regulatory sequences directing tissue-specific expression of transgenes in genetically modified mice and large animals is a prerequisite for the development of adequate models for human diseases. The rat insulin 2 gene (Ins2) promoter, widely used to achieve transgene expression in pancreatic beta-...

journal_title：Molecular and cellular endocrinology

authors： Grzech M,Dahlhoff M,Herbach N,Habermann FA,Renner-Müller I,Wanke R,Flaswinkel H,Wolf E,Schneider MR

更新日期：2010-02-05 00:00:00

abstract：:Stanniocalcin-1 (STC-1) is made by kidney collecting duct cells for autocrine and paracrine targeting of nephron cell mitochondria. Here, the ligand stimulates respiratory uncoupling and calcium uniport activity. However, the underlying purpose of these actions and how the renal gene is regulated are poorly understood...

journal_title：Molecular and cellular endocrinology

authors： Turner J,Xiang FL,Feng Q,Wagner GF

更新日期：2011-01-01 00:00:00

abstract：:Monoclonal antibodies generated to ovine prolactin were screened for their ability to neutralize the biological activity of prolactin from several species. By Western blot analysis, antibody 6F11 cross-reacted strongly with prolactin in homogenates of anterior pituitary glands from squirrel monkey, sheep and rat. In a...

journal_title：Molecular and cellular endocrinology

authors： Scammell JG,Wear LB,Von Haven R

更新日期：1990-06-18 00:00:00

abstract：:The expression of the three genes encoding the components C1, C2 and C3 of prostatic binding protein (PBP) is under androgen control and restricted to the rat ventral prostate. The SstI-PvuII fragment of the first intron of the C3(1) gene displays two binding sites for ubiquitous transcription factors and one for a ti...

journal_title：Molecular and cellular endocrinology

authors： Celis L,Claessens F,Peeters B,Heyns W,Verhoeven G,Rombauts W

更新日期：1993-08-01 00:00:00

abstract：:Perfluorooctanoic acid (PFOA) is a persistent pollutant worldwide and even found in human cord blood and breast milk. Some animal studies have reported that PFOA causes developmental toxicity such as fetal weight loss, but the mechanism is still unclear. This study focused on developmental toxicity of PFOA, particular...

journal_title：Molecular and cellular endocrinology

authors： Suh CH,Cho NK,Lee CK,Lee CH,Kim DH,Kim JH,Son BC,Lee JT

更新日期：2011-04-30 00:00:00

abstract：:Glyphosate (Gly) is the herbicide widely used in agricultural fields and landscaping. Mammalian exposure to glyphosate could cause neurotoxicity, blood, liver, kidney, endocrine, reproductive, genetic and other toxic effects. Melatonin (MT) is a neuroendocrine hormone secreted mainly by the pineal gland. It is unknown...

journal_title：Molecular and cellular endocrinology

authors： Zhang J,Zhao C,Shi F,Zhang S,Wang S,Feng X

更新日期：2021-01-15 00:00:00

abstract：:The aim of this work was to determine whether treatments of rats with estradiol (E) in conditions known to decrease the proliferation rate, the mitotic index and the thymidine incorporation into the DNA of the MtTF4 tumor act at a specific point in the cell cycle. Two weeks after grafting a piece of tumor under the ki...

journal_title：Molecular and cellular endocrinology

authors： Pharaboz MO,Cordier G,André J

更新日期：1986-12-01 00:00:00

abstract：:The enzyme aromatase converts androgens to estrogens, which have recently been postulated to be essential for testicular development and fertility. Understanding the mechanisms that regulate aromatase activity in the testis may therefore have implications for treatment of male infertility. Aromatase is encoded by the ...

journal_title：Molecular and cellular endocrinology

authors： Sierens J,Jakody I,Poobalan Y,Meachem SJ,Knower K,Young MJ,Sirianni R,Pezzi V,Clyne CD

更新日期：2010-07-29 00:00:00

abstract：:This study examines the effect of preincubation of sheep ovarian follicles with hCG or FSH on the ability of isolated theca and granulosa to increase cAMP levels in response to a second incubation with hCG or FSH. Secondly, the effect of preincubation of small follicles with hCG on androstenedione and testosterone pro...

journal_title：Molecular and cellular endocrinology

authors： Weiss TJ,Armstrong DT

更新日期：1979-03-01 00:00:00

abstract：:The objective of this study was to analyze the correlation between matrix metalloproteinases (MMPs) and angiogenic genes and survival in advanced-stage ovarian carcinomas. Primary and metastatic ovarian carcinomas from patients diagnosed with FIGO stage III-IV disease and followed up to 20 years were studied using mRN...

journal_title：Molecular and cellular endocrinology

authors： Davidson B,Goldberg I,Gotlieb WH,Kopolovic J,Ben-Baruch G,Nesland JM,Reich R

更新日期：2002-02-22 00:00:00

abstract：:The distribution and molecular forms of bombesin-like immunoreactivity (BLI) were determined in the ovine median eminence using a new, C-terminally directed antiserum. BLI was confined to neurons of the external zone of the median eminence, near small blood vessels, many of which also were immunoreactive for CRF. Each...

journal_title：Molecular and cellular endocrinology

authors： Giraud AS,Smith AI,Rundle SE

更新日期：1987-10-01 00:00:00

abstract：:The role of AII receptors subtypes, AT1 and AT2, in the regulation of aldosterone secretion was studied in adrenal glomerulosa cells and membranes from rats on normal and low sodium intake, using AII receptor subtype-specific antagonists. In adrenal glomerulosa cells, more than 90% of the receptors were AT1 and there ...

journal_title：Molecular and cellular endocrinology

authors： Aguilera G

更新日期：1992-12-01 00:00:00

abstract：:At the early stage of its development in 1957, the daily dose of spironolactone necessary to improve various pathological conditions was not precisely determined and dose-dependent sexual side effects limited its long-term use. Prescription of high daily doses and absence of selectivity for the mineralocorticoid recep...

journal_title：Molecular and cellular endocrinology

authors： Ménard J

更新日期：2004-03-31 00:00:00

abstract：:Procedures have been developed which provide simple means of determining binding constants of steroid receptors for glucocorticoids in mouse lymphoid cell lines and of characterizing the interaction of the steroid--receptor complex with the nucleus. An average of 70% of the steroid--receptor complexes is found associa...

journal_title：Molecular and cellular endocrinology

authors： Pfahl M,Sandros T,Bourgeois S

更新日期：1978-04-01 00:00:00

abstract：:The present study correlated concentrations of activin A and follistatin in follicular fluid (FF) from human small antral follicles to FF concentrations of AMH, inhibin B, progesterone, and oestradiol and to the mRNA expression of FSH-receptor (FSHR), LH-receptor (LHR), AMH-receptor2 (AMHR2), CYP19a, and androgen-rece...

journal_title：Molecular and cellular endocrinology

authors： Jeppesen JV,Nielsen ME,Kristensen SG,Yding Andersen C

更新日期：2012-06-05 00:00:00

abstract：:Somatostatin (SS) and its synthetic analogs have a role in the treatment of neuroendocrine tumours both in terms of symptoms control and antiproliferative activities. These effects are mediated by five SS receptors, widely expressed in both human neuroendocrine and non-neuroendocrine tumours, which were demonstrated t...

journal_title：Molecular and cellular endocrinology

authors： Volante M,Rosas R,Allìa E,Granata R,Baragli A,Muccioli G,Papotti M

更新日期：2008-05-14 00:00:00

abstract：:Glucocorticoid hormones suppress circulating concentrations of thyrotrophin (TSH), but their effect on synthesis of TSH in the pituitary gland is unclear. We have examined the influence of the glucocorticoid dexamethasone on serum TSH, pituitary TSH content and TSH beta- and alpha-subunit mRNA concentrations in pituit...

journal_title：Molecular and cellular endocrinology

authors： Ahlquist JA,Franklyn JA,Ramsden DB,Sheppard MC

更新日期：1989-06-01 00:00:00

abstract：:Inhibin is a member of the TGF-beta superfamily of growth and differentiation factors and a tumor suppressor. Consistent with the tumor suppressive function of the inhibin alpha subunit in prostate cancer, we reported a loss of gene expression due to DNA hypermethylation and loss of heterozygosity (LOH) as well as dow...

journal_title：Molecular and cellular endocrinology

authors： Risbridger GP,Ball EM,Wang H,Mellor SL,Peehl DM

更新日期：2004-10-15 00:00:00

abstract：:We have produced transgenic (TG) mice expressing under the ubiquitin C promoter either the glycoprotein hormone common alpha-subunit (C(alpha)) or human chorionic gonadotropin (hCG) beta-subunit. C(alpha) overexpression alone had no phenotypic effect, but the hCG(beta) expressing females, presenting with moderately el...

journal_title：Molecular and cellular endocrinology

authors： Huhtaniemi I,Rulli S,Ahtiainen P,Poutanen M

更新日期：2005-04-29 00:00:00

abstract：:The present experiment used cultured mouse cumulus cell-enclosed oocytes (CEOs) and denuded oocytes (DOs) to study the function of nitric oxide (NO) in mouse oocyte meiotic maturation. Either positive or negative actions of NO on meiotic maturation has been observed when CEOs or DOs were cultured for 24 h in a medium ...

journal_title：Molecular and cellular endocrinology

authors： Bu S,Xia G,Tao Y,Lei L,Zhou B

更新日期：2003-09-30 00:00:00

abstract：:In this paper, we identify three different MRAPs in zebrafish, zfMRAP1, zfMRAP2a and zfMRAP2b, and demonstrate that zfMC2R is not functional in the absence of MRAP expression. ZfMRAP1 expression was restricted to adipose tissue and the anterior kidney whereas MRAP2a and MRAP2b were expressed in all the tissues tested....

journal_title：Molecular and cellular endocrinology

authors： Agulleiro MJ,Roy S,Sánchez E,Puchol S,Gallo-Payet N,Cerdá-Reverter JM

更新日期：2010-05-14 00:00:00

abstract：:Proliferation of breast cancer cells is mediated by estrogen receptors (ER)-ERalpha and ERbeta. At present, contradictory observations complicate the understanding of involvement of ERbeta in breast cancer and functional definition of ERbeta as a prognostic marker. A stable expression of full length ERbeta was establi...

journal_title：Molecular and cellular endocrinology

authors： Behrens D,Gill JH,Fichtner I

更新日期：2007-08-15 00:00:00

abstract：:The underlying mechanism leading to rupture of the membranes at parturition is not fully understood. Lysyl oxidase (LOX) cross-links collagen fibrils thereby increasing the tensile strength of the membranes. Thus, understanding the regulation of LOX expression may be of crucial importance for elucidation of the proces...

journal_title：Molecular and cellular endocrinology

authors： Liu C,Zhu P,Wang W,Li W,Shu Q,Chen ZJ,Myatt L,Sun K

更新日期：2016-03-15 00:00:00

abstract：:Estetrol (E4) is a natural estrogen synthesized exclusively during pregnancy by the human fetal liver, and the physiological role of this hormone is unknown. Interestingly, E4 was recently evaluated in preclinical and phase II-III clinical studies in combination with a progestin, with the advantage to not increase the...

journal_title：Molecular and cellular endocrinology

authors： Valéra MC,Noirrit-Esclassan E,Dupuis M,Fontaine C,Lenfant F,Briaux A,Cabou C,Garcia C,Lairez O,Foidart JM,Payrastre B,Arnal JF

更新日期：2018-12-05 00:00:00

abstract：:Protein biosynthesis in neurointermediate lobes of mouse pituitaries was investigated using pulse and pulse-chase techniques with [3H]lysine. Electrophoretic analysis of lobe homogenates on acid-urea gels resolved 11 labeled products. One was a large protein which was rapidly synthesized during pulse-incubations and d...

journal_title：Molecular and cellular endocrinology

authors： Jenks BG,Meulepas WJ,Soons PJ,van Overbeeke AP

更新日期：1979-02-01 00:00:00

abstract：:The effect of thyroid status on the postnatal development of the two molecular forms of Na+,K+-ATPase, distinguished kinetically on the basis of their ouabain sensitivity, was examined in rat brain. Hypothyroidism induced by PTU from day 1 postnatally significantly reduced the Na+,K+-ATPase activity in cerebellum (22-...

journal_title：Molecular and cellular endocrinology

authors： Atterwill CK,Reid J,Athayde CM

更新日期：1985-05-01 00:00:00

abstract：:The oligosaccharide chains of pituitary glycoprotein hormones such as human thyroid-stimulating hormone (hTSH) have been shown to be important in biosynthesis, subunit association, secretion and bioactivity. However, the exact biological significance of these glycosylation variants (isoforms) remains controversial. Th...

journal_title：Molecular and cellular endocrinology

authors： Schaaf L,Leiprecht A,Saji M,Hübner U,Usadel KH,Kohn LD

更新日期：1997-09-19 00:00:00

abstract：:The angiotensin II (AngII) type 1 (AT(1)) receptor is a seven-transmembrane G protein-coupled receptor, and is involved in regulating the physiological and pathological process of the cardiovascular system. Systemically and locally generated AngII has agonistic action on AT(1) receptor, but recent studies have demonst...

journal_title：Molecular and cellular endocrinology

authors： Akazawa H,Yasuda N,Komuro I

更新日期：2009-04-29 00:00:00

abstract：:This study examines the effect of FSH, testosterone and estradiol on testicular LH receptors and in vitro testicular responsiveness to LH in immature rats under various conditions. FSH treatment of 15-day-old immature rats significantly increased the number of LH receptors but did not alter testicular responsiveness. ...

journal_title：Molecular and cellular endocrinology

authors： Chen YD,Shaw MJ,Payne AH

更新日期：1977-10-01 00:00:00

abstract：:Genomewide association studies (GWAS) have indicated that SNPs on a chromosome 16 locus encompassing FTO, as well as IRX3, 5, 6, FTM and FTL are robustly associated with human obesity. GWAS, however, are by nature gene agnostic, and SNPs reaching the appropriate statistical threshold for a given phenotype can appear a...

journal_title：Molecular and cellular endocrinology

authors： Yeo GS

更新日期：2014-11-01 00:00:00