Somatostatin, cortistatin and their receptors in tumours.

abstract：:The peculiarities of cellular and tissue distribution of prolactin receptors (PRLR) in the liver of female and male rats with different sex steroid status were investigated in paraplast-embedded tissue with the indirect immunoperoxidase technique. Two clones of antibodies directed outside the PRL-binding site (U6) or ...

journal_title：Molecular and cellular endocrinology

authors： Smirnova OV,Petraschuk OM,Kelly PA

更新日期：1994-10-01 00:00:00

abstract：:Different factors are involved in thyroid function and proliferation such as thyrotropin (TSH), insulin, growth factors, iodide, etc. TSH and IGF1/insulin increase proliferation rate and stimulate genes involved in thyroid differentiation. In the present study, we analyse the physiological regulation of NOX4 expressio...

journal_title：Molecular and cellular endocrinology

authors： Oglio R,Salvarredi L,Rossich L,Copelli S,Pisarev M,Juvenal G,Thomasz L

更新日期：2019-01-15 00:00:00

abstract：:Skeletal muscle atrophy is a debilitating response to several major diseases, muscle disuse and chronic steroid treatment for which currently no therapy is available. Since adiponectin signaling plays key roles in muscle energetics, we assessed if globular adiponectin (gAd) or the small molecule adiponectin mimetic 6-...

journal_title：Molecular and cellular endocrinology

authors： Singh AK,Shree S,Chattopadhyay S,Kumar S,Gurjar A,Kushwaha S,Kumar H,Trivedi AK,Chattopadhyay N,Maurya R,Ramachandran R,Sanyal S

更新日期：2017-01-05 00:00:00

abstract：:Thymocytes from SJL/J mice exhibit a periodicity in their response to hormonal stimulation with isoproterenol. This periodicity (5-9 days) is expressed in large changes in the intensity of the response (peak levels of intracellular cAMP which vary approximately 6-fold), and in the response pattern, i.e., in the occurr...

journal_title：Molecular and cellular endocrinology

authors： Riven-Kreitman R,Tauber-Finkelstein M,Zipori D,Shaltiel S

更新日期：1990-10-22 00:00:00

abstract：:All mammalian cells rely on adenosine triphosphate (ATP) to maintain function and for survival. The heart has the highest basal ATP demand of any organ due to the necessity for continuous contraction. As such, the ability of the cardiomyocyte to monitor cellular energy status and adapt the supply of substrates to matc...

journal_title：Molecular and cellular endocrinology

authors： Nagendran J,Waller TJ,Dyck JR

更新日期：2013-02-25 00:00:00

abstract：:Wnt signaling is an evolutionarily conserved pathway that regulates cell proliferation, differentiation and apoptosis. To investigate the possible role of Wnt signaling in the regulation of ovarian follicular development, secondary follicles were isolated and cultured in vitro in the presence or absence of its activat...

journal_title：Molecular and cellular endocrinology

authors： Li L,Ji SY,Yang JL,Li XX,Zhang J,Zhang Y,Hu ZY,Liu YX

更新日期：2014-02-15 00:00:00

abstract：:The placenta plays an essential role in fetal growth and the maintenance of pregnancy and its functions are strictly controlled in a stage-specific manner. To gain an insight into placental functions and their regulation, we analyzed the plasma membrane proteins of rat placenta by two-dimensional polyacrylamide gel el...

journal_title：Molecular and cellular endocrinology

authors： Ishimura R,Noda K,Hattori N,Shiota K,Ogawa T

更新日期：1995-12-29 00:00:00

abstract：:Somatostatin (SST) regulates multiple biological processes via five genetically distinct, G-protein coupled receptors. Clinical interest in therapy for neuroendocrine and metabolic disorders has resulted in the development of new tools for exploring the function of somatostatin receptors (SSTRs). The development of hi...

journal_title：Molecular and cellular endocrinology

authors： Strowski MZ,Blake AD

更新日期：2008-05-14 00:00:00

abstract：:This report represents the joint efforts of three laboratories, one with a primary interest in understanding regulatory processes in the epididymal epithelium (TTT) and two with a primary interest in identifying and characterizing new contraceptive targets (DSJ and SAJ). We have developed a highly refined mouse epidid...

journal_title：Molecular and cellular endocrinology

authors： Turner TT,Johnston DS,Jelinsky SA

更新日期：2006-05-16 00:00:00

abstract：:Evidence from in vitro studies and naturally occurring human diseases indicate that several endocrine cells, and particularly somatotrophs, recognize cAMP as a growth factor. Accordingly, mutations of the alpha subunit of the stimulatory G protein gene (GNAS) leading to the constitutive activation of adenylyl cyclase ...

journal_title：Molecular and cellular endocrinology

authors： Mantovani G,Lania AG,Spada A

更新日期：2010-09-15 00:00:00

abstract：:Evidence is accumulating that environmental chemicals (ECs) including endocrine-disrupting compounds (EDCs) can alter female reproductive development, fertility and onset of menopause. While not as clearly defined as in the male, this set of abnormalities may constitute an Ovarian Dysgenesis Syndrome with at least som...

journal_title：Molecular and cellular endocrinology

authors： Fowler PA,Bellingham M,Sinclair KD,Evans NP,Pocar P,Fischer B,Schaedlich K,Schmidt JS,Amezaga MR,Bhattacharya S,Rhind SM,O'Shaughnessy PJ

更新日期：2012-05-22 00:00:00

abstract：:Stanniocalcin-1 (STC-1) is made by kidney collecting duct cells for autocrine and paracrine targeting of nephron cell mitochondria. Here, the ligand stimulates respiratory uncoupling and calcium uniport activity. However, the underlying purpose of these actions and how the renal gene is regulated are poorly understood...

journal_title：Molecular and cellular endocrinology

authors： Turner J,Xiang FL,Feng Q,Wagner GF

更新日期：2011-01-01 00:00:00

abstract：:We previously described an androgen receptor (AR) point mutation located in the DNA-binding domain (DBD), adjacent to another AR substitution. Both were observed in two unrelated families with male breast cancer (MBC) and partial androgen insensitivity syndrome. This work was designed to determine the potential role o...

journal_title：Molecular and cellular endocrinology

authors： Poujol N,Lobaccaro JM,Chiche L,Lumbroso S,Sultan C

更新日期：1997-06-20 00:00:00

abstract：:In light of current discussions on multiple forms of inhibin, it was thought of interest to ascertain the identity of the postulated 'iso-hormones' of bull seminal plasma inhibin (Chari et al., 1978). By subjecting the biologically active fraction, obtained by Sephadex G-100 gel filtration of bull seminal plasma aceto...

journal_title：Molecular and cellular endocrinology

authors： Mohapatra SK,Duraiswami S,Chari S

更新日期：1985-07-01 00:00:00

abstract：:Estrogen plays a major role in bone mineral homeostasis, maintaining a balance between bone formation and bone resorption not only in women but also in men. Extraglandular aromatization of circulating androgen is the major source of estrogen in post-menopausal women and men. In order to assess the capacity of bone cel...

journal_title：Molecular and cellular endocrinology

authors： Shozu M,Simpson ER

更新日期：1998-04-30 00:00:00

abstract：:Direct roles of follicle-stimulating hormone (FSH)-suppressing protein (FSP) and activin in regulation of ovarian granulosa cell differentiation have been reported recently. The present study further investigated the effects of these peptides on steroidogenesis and inhibin production as well as cAMP generation in cult...

journal_title：Molecular and cellular endocrinology

authors： Xiao S,Findlay JK

更新日期：1991-08-01 00:00:00

abstract：:17beta-hydroxysteroid dehydrogenase type 7 (17beta-HSD7) is a novel estrogenic hydroxysteroid dehydrogenase from mammals. We modeled the three-dimensional structure of human 17beta-HSD7, analyzed the phylogeny of 17beta-HSD7 homologues and determined its expression pattern by in silico Northern blotting. Predominant e...

journal_title：Molecular and cellular endocrinology

authors： Breitling R,Krazeisen A,Möller G,Adamski J

更新日期：2001-01-22 00:00:00

abstract：:Five overlapping synthetic peptides representing two regions of thyrotropin (TSH) binding sites of human thyrotropin receptor (TSHR) (peptides 12-30, 24-44, 308-328, 324-344 and 339-364) were investigated for their ability to cause proliferation of peripheral blood lymphocytes (PBL) from eight patients with Graves' di...

journal_title：Molecular and cellular endocrinology

authors： Sakata S,Tanaka S,Okuda K,Miura K,Manshouri T,Atassi MZ

更新日期：1993-03-01 00:00:00

abstract：:Pioglitazone belongs to the class of drugs called thiazolidinediones (TZDs), which are widely used as insulin sensitizers in the treatment of diabetes. A major side effect of TZDs is fluid retention. The steroid hormone aldosterone also promotes sodium and fluid retention; however, the effect of pioglitazone on aldost...

journal_title：Molecular and cellular endocrinology

authors： Pan ZQ,Xie D,Choudhary V,Seremwe M,Tsai YY,Olala L,Chen X,Bollag WB

更新日期：2014-08-25 00:00:00

abstract：:The ovarian granulosa cell has previously been shown to be a site of insulin-like growth factor (IGF) I production, reception, and action. It is the objective of this study to characterize in greater detail the soluble IGF binding activity released by this cell type. To this end, use was made of granulosa cells from i...

journal_title：Molecular and cellular endocrinology

authors： Adashi EY,Resnick CE,Hernandez ER,Hurwitz A,Rosenfeld RG

更新日期：1990-12-21 00:00:00

abstract：:Set/template-activating factor (TAF)-Ibeta, part of the Set-Can oncogene product found in acute undifferentiated leukemia, is a component of the inhibitor of acetyltransferases (INHAT) complex. Set/TAF-Ibeta interacted with the DNA-binding domain of the glucocorticoid receptor (GR) in yeast two-hybrid screening, and r...

journal_title：Molecular and cellular endocrinology

authors： Ichijo T,Chrousos GP,Kino T

更新日期：2008-02-13 00:00:00

abstract：:Thyroid oncocytic neoplasms are tumors composed of cells characterized by an aberrant increase of mitochondrial mass. They represent a subset of thyroid tumors whose classification and clinical features has been a matter of controversy for clinicians and pathologists alike. The prevalence of oncocytic tumors in the th...

journal_title：Molecular and cellular endocrinology

authors： Gasparre G,Bonora E,Tallini G,Romeo G

更新日期：2010-05-28 00:00:00

abstract：:Peripheral benzodiazepine (BZ) binding sites (PBzS) were characterized on placental explant membranes. [3H]PK 11195, an isoquinoline carboxamide derivative, which is a ligand specific for PBzS, labeled these sites with an equilibrium dissociation constant of 2.1 nM; the maximal number of binding sites was 396 fmol/mg ...

journal_title：Molecular and cellular endocrinology

authors： Barnea ER,Fares F,Gavish M

更新日期：1989-07-01 00:00:00

abstract：:Forskolin, a diterpene hypotensive drug, activates adenylate cyclase in brain and in some other tissues (Seamon et al., 1981). Forskolin activated adenylate cyclase in particulate preparations and enhanced cyclic AMP accumulation in slices of dog thyroid. These effects were maximal within minutes and remained constant...

journal_title：Molecular and cellular endocrinology

authors： Van Sande J,Cochaux P,Mockel J,Dumont JE

更新日期：1983-01-01 00:00:00

abstract：:Oestrogens are known to exert specific stimulatory effects on basal and dopamine (DA)-inhibited prolactin (PRL) release as well as on PRL cell content in rat adenohypophysial cells in primary culture. Recently, we have demonstrated that classical oestrogens increase growth hormone (GH) release and cellular GH content ...

journal_title：Molecular and cellular endocrinology

authors： Simard J,Vincent A,Duchesne R,Labrie F

更新日期：1988-02-01 00:00:00

abstract：:Hyperthyroidism was induced in rats and somatic indices and metabolic parameters were analyzed in testis. In addition, the morphological analysis evidenced testes maturation and intense protein synthesis and processing, supporting the enhancement in vimentin synthesis in hyperthyroid testis. Furthermore, vimentin phos...

journal_title：Molecular and cellular endocrinology

authors： Zamoner A,Barreto KP,Filho DW,Sell F,Woehl VM,Guma FC,Silva FR,Pessoa-Pureur R

更新日期：2007-03-15 00:00:00

abstract：:This study examines the effect of FSH, testosterone and estradiol on testicular LH receptors and in vitro testicular responsiveness to LH in immature rats under various conditions. FSH treatment of 15-day-old immature rats significantly increased the number of LH receptors but did not alter testicular responsiveness. ...

journal_title：Molecular and cellular endocrinology

authors： Chen YD,Shaw MJ,Payne AH

更新日期：1977-10-01 00:00:00

abstract：:Previous studies have indicated that following nutrient ingestion, GIP is released principally from the upper small intestine. In addition to its presence in the rat small intestine, GIP transcripts have also been localized to the submandibular salivary gland (SSG). The present studies were directed to further charact...

journal_title：Molecular and cellular endocrinology

authors： Tseng CC,Boylan MO,Jarboe LA,Williams EK,Sunday ME,Wolfe MM

更新日期：1995-11-30 00:00:00

abstract：:Transthyretin (TTR) is a plasma thyroid hormone (TH) binder that emerged from an ancient hydroxyisourate hydrolase by gene duplication. To know how an ancient TTR had high affinity for THs, molecular and TH binding properties of lamprey TTRs were investigated. In adult serum, the lipoprotein LAL was a major T3 binder ...

journal_title：Molecular and cellular endocrinology

authors： Kasai K,Nishiyama N,Yamauchi K

更新日期：2018-10-15 00:00:00

abstract：:Granulosa cells of small follicles differentiate in vitro in serum-free medium, resulting in increased estradiol secretion and abundance of mRNA encoding cytochrome P450aromatase (P450arom). We tested the hypothesis that differentiation in vitro also involves increased expression of 3beta- and 17beta-hydroxysteroid de...

journal_title：Molecular and cellular endocrinology

authors： Sahmi M,Nicola ES,Silva JM,Price CA

更新日期：2004-08-31 00:00:00