Activated glucocorticoid receptor interacts with the INHAT component Set/TAF-Ibeta and releases it from a glucocorticoid-responsive gene promoter, relieving repression: implications for the pathogenesis of glucocorticoid resistance in acute undifferentiat

abstract：:It has been reported that testicular Sertoli cells can be induced to synthesize the steroidogenic acute regulatory (StAR) protein. StAR mediates the rate-limiting step of steroidogenesis, which is the transfer of cholesterol to the inner mitochondrial membrane. Since Sertoli cells are thought to be unable to utilize c...

journal_title：Molecular and cellular endocrinology

authors： Ford SL,Reinhart AJ,Lukyanenko Y,Hutson JC,Stocco DM

更新日期：1999-11-25 00:00:00

abstract：:Corticotropin (ACTH) regulates glucocorticoid production through specific receptors on the adrenal cortex. Analysis of the ACTH receptor mRNA in human adrenal has revealed the presence of five transcripts ranging from 1.8 to 11 kilobases (kb). Characterization of the 5'-untranslated regions (UTRs) of the ACTH receptor...

journal_title：Molecular and cellular endocrinology

authors： Naville D,Barjhoux L,Jaillard C,Lebrethon MC,Saez JM,Bégeot M

更新日期：1994-12-01 00:00:00

abstract：:The Nile tilapia, Oreochromis niloticus, is a gonochoristic teleost fish with an XX/XY genetic system and is an excellent model for gonadal sex differentiation. In the present study, we screened novel genes that were expressed predominantly in either XY or XX undifferentiated gonads during the critical period for diff...

journal_title：Molecular and cellular endocrinology

authors： Kaneko H,Ijiri S,Kobayashi T,Izumi H,Kuramochi Y,Wang DS,Mizuno S,Nagahama Y

更新日期：2015-11-05 00:00:00

abstract：:Insulin and cAMP stimulate prolactin gene transcription and prolactin-CAT expression in rat pituitary tumor GH cells. Expression of prolactin-CAT construct, pPrl(-173/+75)CAT, is stimulated 10- to 30-fold by either insulin or cAMP. Addition of both insulin and cAMP resulted in an additive 20- to 60-fold stimulation. A...

journal_title：Molecular and cellular endocrinology

authors： Jacob KK,Stanley FM

更新日期：1995-04-01 00:00:00

abstract：:Protection of the spermatogenic cells from the host immune response is fundamental to male fertility. Significantly, this protection extends to the tolerance of foreign tissue grafts placed within the testicular environment, a phenomenon that is called 'immune privilege'. This privilege of the testis appears to involv...

journal_title：Molecular and cellular endocrinology

authors： Meinhardt A,Hedger MP

更新日期：2011-03-15 00:00:00

abstract：:Cell-cell interactions are crucial role for the proper functioning of endocrine glands. We recently demonstrated that interactions of chromaffin and cortical cells are important for adrenocortical steroidogenesis. However, the molecular mechanisms have not been elucidated and it is unclear if this involves acute and/o...

journal_title：Molecular and cellular endocrinology

authors： Haidan A,Bornstein SR,Liu Z,Walsh LP,Stocco DM,Ehrhart-Bornstein M

更新日期：2000-07-25 00:00:00

abstract：:Endocrine dysfunction in mitochondrial disease is commonplace, but predominantly restricted to disease of the endocrine pancreas resulting in diabetes mellitus. Other endocrine manifestations occur, but are relatively rare by comparison. In mitochondrial disease, neuromuscular symptoms often dominate the clinical phen...

journal_title：Molecular and cellular endocrinology

authors： Schaefer AM,Walker M,Turnbull DM,Taylor RW

更新日期：2013-10-15 00:00:00

abstract：:The insulinotropic effects of alpha-ketoisocaproic acid and glucose reveal many common characteristics in vivo and in vitro. They qualify as initiators of insulin release, their action is amplified by potentiators of insulin release, and they have a similar potency at equimolar concentrations. The dynamics of insulin ...

journal_title：Molecular and cellular endocrinology

authors： Schauder P,McIntosh C,Schindler B,Panten U,Frerichs H

更新日期：1978-06-01 00:00:00

abstract：:1,25-Dihydroxyvitamin D (1,25(OH)(2)D) plays a critical role in calcium and phosphorus (Pi) metabolism, bone growth, and tissue differentiation. The synthesis of 1,25(OH)(2)D in the proximal renal tubule is the primary determinant of its circulating concentration and is mediated by the mitochondrial enzyme, 25-hydroxy...

journal_title：Molecular and cellular endocrinology

authors： Perwad F,Portale AA

更新日期：2011-12-05 00:00:00

abstract：:The in vitro secretion of immunoreactive somatomedin C/insulin-like growth factor I (IR Sm-C/IGF-I) by two human breast cancer cell lines, MCF-7 and EVSA-T has been studied. IR Sm-C/IGF-I concentration showed a linear increase in serum-free culture media over 72 h of incubation for both cell lines, and a close correla...

journal_title：Molecular and cellular endocrinology

authors： Minuto F,Del Monte P,Barreca A,Nicolin A,Giordano G

更新日期：1987-12-01 00:00:00

abstract：:Steroidogenic Factor 1 (SF-1, Ad4bp, NR5A1) is a nuclear receptor expressed mainly in the adrenals and gonads. It activates the transcription of genes in steroidogenesis, reproduction, and energy metabolism. In addition, it also regulates the growth and differentiation of adrenogonadal primodial cells. SF-1 resides in...

journal_title：Molecular and cellular endocrinology

authors： Wang CY,Chen WY,Lai PY,Chung BC

更新日期：2013-05-22 00:00:00

abstract：:Estrogen receptor alpha (ERalpha) mediates estrogen (E2) actions in the brain and is critical for normal reproductive function and behavior. In the classical pathway, ERalpha binds to estrogen response elements (EREs) to regulate gene transcription. ERalpha can also participate in several non-classical pathways, inclu...

journal_title：Molecular and cellular endocrinology

authors： McDevitt MA,Glidewell-Kenney C,Jimenez MA,Ahearn PC,Weiss J,Jameson JL,Levine JE

更新日期：2008-08-13 00:00:00

abstract：:Human breast cancer cells selected for multidrug resistance frequently overexpress ligands and receptors in the epidermal growth factor (EGF) receptor family. To determine whether this overexpression contributes to the drug resistant phenotype, EGF receptor transfected ZR75B human breast cancer cells were examined. Tw...

journal_title：Molecular and cellular endocrinology

authors： Dickstein BM,Wosikowski K,Bates SE

更新日期：1995-04-28 00:00:00

abstract：:Trophoblast cells produce several inmmuneregulators like the Vasoactive Intestinal Peptide (VIP) and P4 targeting multiple circuits, and also display an intese phagocytic ability allowing embryo implantation in a tolerogenic context. Here, we explored whether P4 and VIP- crosstalk modulates trophoblast cell function, ...

journal_title：Molecular and cellular endocrinology

authors： Vota D,Aguero M,Grasso E,Hauk V,Gallino L,Soczewski E,Pérez Leirós C,Ramhorst R

更新日期：2017-03-05 00:00:00

abstract：:The effects of tamoxifen (Tam) and its 4-hydroxylated metabolite (OH-Tam) on the growth of two human breast cancer cell lines ( MCF7 and BT20 ) were evaluated by fluorometric DNA assay. The effects of the antiestrogens were dependent upon their concentrations and the nature of the cells. At concentrations below 4 micr...

journal_title：Molecular and cellular endocrinology

authors： Bardon S,Vignon F,Derocq D,Rochefort H

更新日期：1984-05-01 00:00:00

abstract：:Accumulating evidence suggests that the human follitropin receptor is unusually sensitive to mutation. Previous results (Mol. Cell. Endo. 166 (2000) 101) determined that scanning mutations in a.a. 12-14 and 22-30 neither bound follitropin nor were present on the cell surface, suggesting that these regions are involved...

journal_title：Molecular and cellular endocrinology

authors： Nechamen CA,Dias JA

更新日期：2003-03-28 00:00:00

abstract：:The present study examines the involvement of cAMP in the transduction of the short-term effect of gonadotropin-releasing hormone (GnRH) on gonadotropin release in the teleost fish, tilapia. A 5 min pulse of dibutyryl cyclic AMP (dbcAMP; 0.03-3 mM) or forskolin (0.1-10 microM) resulted in dose-dependent surges in tila...

journal_title：Molecular and cellular endocrinology

authors： Levavi-Sivan B,Yaron Z

更新日期：1992-06-01 00:00:00

abstract：:The role of estrogens produced by the testis may involve negative feedback regulation of androgen biosynthesis. Estrogens are also associated with contractile processes of seminiferous tubules, and might have mitogenic effects on Sertoli and Leydig cells. To investigate the location of aromatase (estrogen synthetase) ...

journal_title：Molecular and cellular endocrinology

authors： Brodie A,Inkster S,Yue W

更新日期：2001-06-10 00:00:00

abstract：:Eating disorders, namely anorexia nervosa, bulimia nervosa and binge eating disorder are frequent diseases and often complicated by comorbidities, e.g. psychiatric or cardiovascular comorbidities. It is to note that also gastrointestinal symptoms/complications are frequently observed in patients with eating disorders....

journal_title：Molecular and cellular endocrinology

authors： Hetterich L,Mack I,Giel KE,Zipfel S,Stengel A

更新日期：2019-11-01 00:00:00

abstract：:Regulation of hormonal, insulin/IGF-1 (Ins/IGF-1) signaling activities, and pathways of the intrinsic generation of reactive oxygen species (ROS) play a role in aging and longevity determination. In this review we discuss the cross-talk between these pathways as mechanisms of signaling that may be important factors in...

journal_title：Molecular and cellular endocrinology

authors： Papaconstantinou J

更新日期：2009-02-05 00:00:00

abstract：:Glucose transport activity ([3H]D-glucose uptake) in liver sinusoidal membrane vesicles (SMVs) from hyperthyroid rats was significantly higher than that from euthyroid controls (2.1-times increase in V(max) with K(m) unchanged at approximately 18 mM), associated with increased GLUT2 expression. In contrast, glucose tr...

journal_title：Molecular and cellular endocrinology

authors： Kemp HF,Hundal HS,Taylor PM

更新日期：1997-04-04 00:00:00

abstract：:Glucocorticoids (GCs) exert profound effects on bone and are essential for human osteoblast differentiation. However, GCs are still interpreted as negative regulators of bone formation, mainly caused by the detrimental effects on bone after clinical use of GCs. In this paper we emphasize the importance of GCs for prop...

journal_title：Molecular and cellular endocrinology

authors： Eijken M,Koedam M,van Driel M,Buurman CJ,Pols HA,van Leeuwen JP

更新日期：2006-03-27 00:00:00

abstract：:Administration of 0.1 or 1 mg of prednisolone to fed mice caused a 5-fold activation of glycogen synthase in the liver after 3h, without significant changes in the circulating levels of glucose or insulin, or the hepatic concentration of cyclic AMP. Adrenalectomized fasted rats responded to cortisol (10 mg) with an in...

journal_title：Molecular and cellular endocrinology

authors： Vanstapel F,Bollen M,de Wulf H,Stalmans W

更新日期：1982-06-01 00:00:00

abstract：:Platelet-derived growth factor (PDGF) is a potent mitogen for several cell types. In addition, PDGF has vasoconstrictive action and shares some signal transduction mechanisms with angiotensin II (AII). In the present study, we have examined the effects of PDGF on basal and AII-induced aldosterone synthesis in freshly ...

journal_title：Molecular and cellular endocrinology

authors： Natarajan R,Nadler J

更新日期：1992-01-01 00:00:00

abstract：:The effects of thyroid hormone on insulin-like growth factor I (IGF-I) production by Sertoli cells isolated from immature rats have been investigated. In Sertoli cells from hypothyroid rats the production of IGF-I was significantly lower than in controls and was greatly stimulated by the administration of triiodothyro...

journal_title：Molecular and cellular endocrinology

authors： Palmero S,Prati M,Barreca A,Minuto F,Giordano G,Fugassa E

更新日期：1990-01-02 00:00:00

abstract：:Hyperthyroidism was induced in rats and somatic indices and metabolic parameters were analyzed in testis. In addition, the morphological analysis evidenced testes maturation and intense protein synthesis and processing, supporting the enhancement in vimentin synthesis in hyperthyroid testis. Furthermore, vimentin phos...

journal_title：Molecular and cellular endocrinology

authors： Zamoner A,Barreto KP,Filho DW,Sell F,Woehl VM,Guma FC,Silva FR,Pessoa-Pureur R

更新日期：2007-03-15 00:00:00

abstract：:This report represents the joint efforts of three laboratories, one with a primary interest in understanding regulatory processes in the epididymal epithelium (TTT) and two with a primary interest in identifying and characterizing new contraceptive targets (DSJ and SAJ). We have developed a highly refined mouse epidid...

journal_title：Molecular and cellular endocrinology

authors： Turner TT,Johnston DS,Jelinsky SA

更新日期：2006-05-16 00:00:00

abstract：:Iodide Organification defects (IOD) represent 10% of cases of congenital hypothyroidism (CH) being the main genes affected that of TPO (thyroid peroxidase) and DUOX2 (dual oxidasa 2). From a patient with clinical and biochemical criteria suggestive with CH associated with IOD, TPO and DUOX2 genes were analyzed by mean...

journal_title：Molecular and cellular endocrinology

authors： Belforte FS,Citterio CE,Testa G,Olcese MC,Sobrero G,Miras MB,Targovnik HM,Rivolta CM

更新日期：2016-01-05 00:00:00

abstract：:Exposure of the oestrogen-dominated rat myometrium to either isoproterenol or PGE2 resulted in a rapid but transient accumulation of cyclic AMP, with a progressive loss of responsiveness to the corresponding agonist. Induction of refractoriness was a time- and dose-related phenomenon. In the earliest time, desensitiza...

journal_title：Molecular and cellular endocrinology

authors： Tougui Z,Do Khac L,Harbon S

更新日期：1980-10-01 00:00:00

abstract：:Receptor-mediated Ca2+ entry was investigated in fura-2-loaded thyroid FRTL-5 cells. Activation of protein kinase C (PKC) by phorbol myristate acetate (PMA) attenuated the ATP-induced increase in intracellular free Ca2+ ([Ca2+]i). In PKC down-regulated cells, the ATP-induced increase in [Ca2+]i was increased compared ...

journal_title：Molecular and cellular endocrinology

authors： Törnquist K

更新日期：1993-05-01 00:00:00